Seoul National University Hospital

Association Between the Preoperative Prognostic Nutritional Index and Postoperative Pulmonary Complications in Gynecological Cancer

Background: The prognostic nutritional index reflects systemic inflammation and nutritional status.This study aimed to evaluate the predicting ability of the preoperative prognostic nutritional index regarding postoperative pulmonary complications in patients with gynecological c...

Predictors of Early Versus Late Atrial Tachyarrhythmia Recurrence After Cryoballoon Ablation by Atrial Fibrillation Type

ABSTRACT Introduction Patient characteristics and predictors of early (ERAT) and late (LRAT) recurrence of atrial tachyarrhythmia by atrial fibrillation (AF) type after cryoballoon ablation (CBA) remain poorly defined. Methods Using the Korean Heart Rhythm Cryoballoon Registry (1...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Vagus nerve stimulation for obesity: an electrical-targeting perspective on physiological themes and translational challenges

Abstract Implantable vagus nerve stimulation (VNS) has been explored as a programmable bioelectronic approach for modulating feeding and metabolic function in obesity. However, obesity-related VNS is not a single uniform intervention. Studies differ in stimulation site, electrode...

Circular RNA circSNRK regulates inflammatory processes and TXNIP expression by acting as a miR-128-3p sponge in age-related macular degeneration

Age-related macular degeneration (AMD) is an ocular disease that causes visual impairment in older individuals, primarily due to degeneration of the retinal pigment epithelium (RPE). In this progressive disease, damaged RPE cells release pro-inflammatory factors into the extracel...

False-positive patterns in optical coherence tomography in hyperopic and myopic eyes

Background/aims This study aimed to evaluate how axial length influences false-positive rates in ganglion cell analysis (GCA) and retinal nerve fibre layer (RNFL) maps and to identify distinct false-positive patterns on optical coherence tomography (OCT) deviation maps across axi...

Niche-resolved transcriptional programs and ΔNp63/NRF2-associated enrichment in post-chemoradiation esophageal squamous cell carcinoma

Spatial organization in esophageal squamous cell carcinoma resection specimens after chemoradiation remains poorly characterized. We profiled 56 patients using Visium spatial transcriptomics and identified eight niches. All 37 evaluated transcriptional signatures showed marked va...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Feasibility and Usability of Immersive Virtual Reality Exergames for Patients With Parkinson’s Disease: A Pilot Study

Objective: To evaluate the feasibility, safety, and usability of a novel fully immersive virtual reality (VR) exergame, designed to incorporate cognitive-motor dual-task training for patients with Parkinson’s disease (PD).Methods: We developed a specialized fully immersive VR exe...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Perceived training needs and barriers among Korean residents: a cross-sectional survey for competency-based education

PURPOSE: Current South Korean resident education relies heavily on apprenticeship models rather than the systematic curricula needed for multifaceted competency development. Therefore, a rigorous needs assessment is required for effective program design, particularly to target ye...

Association between annual air pollutant exposure and thyroid function: a retrospective cross-sectional study

Abstract Aims Despite the high burden of air pollutants, the association between air pollutant exposures and thyroid function in the general population is inconclusive. This study aimed to investigate the association between annual exposure to air pollutants and thyroid function...

Time‐dependent predictors of seizure outcome in grade 1–2 glioma‐related epilepsy

OBJECTIVE: Given the reciprocal interaction between tumor biology and seizure activity, seizure outcomes in low-grade glioma (LGG) may be dynamic and influenced by both tumor- and treatment-related factors. We aimed to identify factors associated with seizure occurrence across di...

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Short tandem repeat (STR) expansion is a major genetic mechanism underlying numerous neurogenetic disorders. However, traditional PCR amplification and short-read next-generation sequencing-based methods often fail to detect large-scale, complex expansions and to capture methylat...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Patterns of failure after primary treatment and prognostic factors in stage I, grade 2-3 endometrial cancer

Purpose: This study aimed to characterize recurrence patterns and identify prognostic factors in patients with stage I, grade 2-3 endometrioid endometrial cancer. Materials and Methods: We retrospectively analyzed 298 patients with 2009 International Federation of Gynecology and...

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherap...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Perioperative outcomes of robot-assisted, laparoscopic or thoracoscopic, and open surgery across 13 cancer operations: a single-institution cohort of 36,208 cases

Abstract To compare perioperative outcomes of robot-assisted surgery, video-assisted (laparoscopic or thoracoscopic) surgery and open surgery across 13 oncologic procedure groups, because aggregate technology-level comparison is confounded by procedure mix and by the calendar tim...

Complex regional pain syndrome research trends

Background: Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by disproportionate regional pain and distinct clinical features such as allodynia and hyperalgesia. We conducted a bibliometric analysis to map the global research landscape of CRPS over t...