Seoul National University Hospital

Thrombotic Risk of Neutrophil Extracellular Traps and Contact System in Patients with Antiphospholipid Antibodies

APAs) and an increased risk of thrombosis [1].In thrombosis, APAs may contribute through the induction of tissue factor expression in endothelial cells and platelet activation.However, the exact mechanisms underlying thrombosis in APS remain unclear.Upon stimulation by microorgan...

Body Weight Change and Dementia Risk in Young and Middle‐Aged Adults With Type 2 Diabetes and Depression: A Nationwide Cohort Study

ABSTRACT Aim Type 2 diabetes mellitus (T2DM) and depression are established risk factors for dementia, yet clinically observable markers of neurocognitive vulnerability in younger adults with these comorbidities remain poorly characterized. We examined whether longitudinal body w...

Personalized deep learning for short-term forecasting of impending atrial fibrillation from continuous wearable ECG signals

Abstract Continuous wearable electrocardiogram (ECG) monitoring is increasingly used for ambulatory arrhythmia surveillance, yet forecasting impending atrial fibrillation (AF) remains challenging because of inter-patient ECG variability. We investigated whether personalizing a gl...

Contrasting Prognostic Value of Discordance Between Resting Distal-to-Aortic Coronary Pressure Ratio and Fractional Flow Reserve in Coronary Artery Disease

BACKGROUND: Discordance between nonhyperemic pressure ratios and fractional flow reserve (FFR), observed in up to 20% of cases, complicates clinical decision-making for coronary revascularization and warrants further investigation of its clinical implications. This study aimed to...

Prognostic implications of the duration of continuous kidney replacement therapy in 3-month survivors of acute kidney injury: findings from the LINKA cohort

The duration of continuous kidney replacement therapy (CKRT) represents a complex clinical surrogate reflecting the severity of systemic illness, the rate of metabolic recovery, and clinical decision-making regarding treatment discontinuation. The effect of CKRT duration on long-...

Postoperative Supraspinatus Muscle Volume Restoration Is Associated With Tendon Healing and Strength Recovery After Rotator Cuff Repair: Deep‐Learning‐Based Volumetric Analysis of the Entire Muscle With Clinical Correlation

Purpose To quantify supraspinatus muscle volume (SPV) change after rotator cuff repair using deep‐learning‐based segmentation of full‐coverage magnetic resonance imaging and evaluate its associations with clinical, radiologic parameters, and retears. Methods This retrospective st...

Symptom-Based Hospitalization Risk Differs Between Ulcerative Colitis and Crohn’s Disease: A Nationwide Emergency Department Study

Presenting symptoms guide emergency department (ED) triage and admission decisions in inflammatory bowel disease (IBD), but whether symptoms have similar predictive value in ulcerative colitis (UC) and Crohn’s disease (CD) remains unclear. We examined disease-specific association...

Real-time AI-assisted nerve tracking for ultrasound-guided nerve identification: a prospective randomized trial

Background Artificial intelligence (AI)-assisted nerve tracking facilitates real-time ultrasound-guided nerve identification, but its effect on independent nerve identification after AI support is removed remains uncertain. Methods In this prospective randomized trial, 80 ultraso...

Younger Age-Related Incidence of Corneal Limbitis Following Pterygium Excision Combined with Conjunctival-Limbal Autograft

Purpose To investigate the incidence, clinical characteristics, and risk factors of corneal limbitis following pterygium excision with conjunctival-limbal autograft.Methods This retrospective study included 63 eyes of 61 patients with primary nasal pterygium who underwent pterygi...

ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars

Post-burn hypertrophic scar (HTS) formation is influenced by the dynamic balance between keratinocyte proliferation and differentiation, a process critical for maintaining skin homeostasis. Serine/threonine kinase 33 (STK33) has emerged as a potential therapeutic target in oncolo...

Immune Checkpoint Inhibitors in Resectable and Locoregionally Advanced HNSCC: Past Lessons, Present Evidence, and Future Directions

Abstract The integration of ICIs has reshaped therapeutic strategies in head and neck squamous cell carcinoma (HNSCC). ICIs are established in recurrent/metastatic (R/M) HNSCC and have been extensively evaluated in resectable and locoregionally advanced (LA) disease, without succ...

ROBOTIC-ARM ASSISTED BICOMPARTMENTAL KNEE ARTHROPLASTY DEMONSTRATES BETTER PHYSIOLOGICAL GAIT THAN TOTAL KNEE ARTHROPLASTY DESPITE SIMILAR PATIENT-REPORTED OUTCOMES

Aims Bicompartmental knee arthroplasty (BKA) preserves the anterior cruciate ligament and uninvolved compartmental anatomy and may therefore better restore physiological gait than total knee arthroplasty (TKA). Although robotic-arm assistance has improved the accuracy and reprodu...

Practice patterns and outcomes of pediatric ERCP using conventional duodenoscopes: a 14-year single-center experience

Endoscopic retrograde cholangiopancreatography (ERCP) is an established therapeutic modality in children with pancreatobiliary disorders. Because pediatric-specific duodenoscopes are not widely available, conventional adult duodenoscopes are commonly used in clinical practice. We...

Long-term exposure to ambient air pollution and an increased risk of hyperuricemia

Abstract Objectives Evidence suggests that ambient air pollution contributes to metabolic dysregulation, including hyperuricemia. However, previous studies were limited to specific groups or regions with relatively high air pollutant concentrations. This study examined the associ...

Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway

Abstract Obesity, marked by visceral fat accumulation, has a complex relationship with the gut microbiome that impacts body weight and fat accumulation. However, previous studies did not account for fat distribution, reflecting only overall fat mass, leaving specifics of this rel...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Surgical Correction of Prosthetic Mitral Valve Paravalvular Leak: Analysis of Long-Term Outcomes

Background: Paravalvular leak involving a prosthetic mitral valve (M-PVL) is a rare but serious complication after mitral valve replacement (MVR). This study evaluated contemporary outcomes after surgical correction of M-PVL and investigated factors associated with its recurrence...

Simulations on Scintillator Thicknesses for Bone Mineral Density Measurement Based on Dual-Layer Flat-Panel Detectors

Background/Objectives: A dual-layer flat-panel detector (DFD), in which two flat-panel detectors are stacked vertically, enables single-shot dual-energy imaging without a fan-beam scanning and switching mechanism in conventional dual-energy X-ray absorptiometry (DXA), the clinica...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Automated segmentation of myopic atrophic lesions on ultra-widefield fundus images: effects of training-set size and color representation

Abstract Purpose To develop and evaluate a deep-learning model for automated segmentation of myopic atrophic lesions on ultra-widefield (UWF) fundus images and to evaluate the effects of training-set size and color representation on segmentation performance. Methods This study in...