Institution
Seoul National University Hospital
Recent research
- Society & EconomicsOpen access
Adolescents with nonsuicidal self-injury (NSSI) often report rewarding experiences, including ‘feeling better’ and ‘eliciting care from others’ following self-injury. These subjective rewarding experiences may reinforce self-injurious behavior and be associated with psychosocial...
- Health & MedicineOpen access
Background/Objectives: Prostaglandin-associated periorbitopathy (PAP) is a common treatment-related burden of prostaglandin analog (PGA) therapy that may compromise long-term glaucoma management. This study evaluated improvement in PAP and changes in intraocular pressure (IOP) af...
- Health & MedicineOpen access
Development and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential
Background: Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.Serine/ threonine-protein kinase 3 (STK3) and STK4 promote mitophagy, leading to reduced mitochondrial mass in adipose tissue.Thus, inhibition of STK3/4 represents a p...
- Health & Medicine
Income Dynamics and Incident Esophageal Cancer: A Retrospective Cohort Study
BACKGROUND: Although socioeconomic status is a recognized risk factor for esophageal cancer (EC), most studies have examined socioeconomic status at a single time point. We investigated the association between income dynamics and incident EC. METHODS: We analyzed 3,361,091 Korean...
- Health & MedicineOpen access
Background Cardiac reverse remodeling and associated clinical outcomes following angiotensin receptor‐neprilysin inhibitor (ARNI) therapy in patients with heart failure (HF) with reduced ejection fraction (EF) remain unclear. We investigated differences in 1‐year echocardiographi...
- AI & ComputingOpen access
Objectives: This study assessed changes in the visibility of the National Health Information Portal (NHIP), operated by the Korea Disease Control and Prevention Agency, across conventional search portals and generative artificial intelligence (AI) platforms. Methods: We analyzed...
- AI & ComputingOpen access
Abstract Preoperative computed tomography (CT) is routinely acquired for planning robotic-assisted total knee arthroplasty (TKA), yet osteophyte burden is not quantitatively characterized. We developed automated CT-based osteophyte quantification and evaluated it against blinded...
- Health & MedicineOpen access
Background: Radiofrequency ablation (RFA) has been proposed for selected patients with low-risk papillary thyroid carcinoma (PTC). This study compared the effectiveness, safety, and procedural characteristics of RFA with those of surgery and other thermal ablation techniques. Met...
- Health & MedicineOpen access
Early Mitral Valve Surgery and Survival in Asymptomatic Severe Primary Mitral Regurgitation
Importance The optimal timing of mitral valve (MV) surgery in patients with asymptomatic severe primary mitral regurgitation (MR) remains uncertain because randomized clinical trials are lacking. Objective To evaluate the association of early MV surgery with long-term survival in...
- Health & Medicine
Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...
- AI & ComputingOpen access
Breast ultrasound is central to breast cancer diagnosis but suffers from substantial inter-observer variability in Breast Imaging Reporting and Data System (BI-RADS) assessment, and existing deep learning models remain opaque. Multimodal large language models promise interpretabl...
- Health & MedicineOpen access
Intestinal helminth infections have become uncommon in Korea but still occur sporadically, either as residual native infections or as imported infections among immigrants. We retrospectively reviewed 4 cases of intestinal helminth infections incidentally identified during colonos...
- BiologyOpen access
Abstract Systematized Nomenclature of Medicine–Clinical Terminology (SNOMED CT) is the principal international standard for semantic interoperability of clinical information, but mapping free-text clinical narratives to SNOMED CT concepts remains labor-intensive. We developed a l...
- Health & MedicineOpen access
The 2025 Korean Guidelines for Cardiopulmonary Resuscitation provide updated, evidence-based recommendations to optimize the transition from intrauterine to extrauterine life. While approximately 85% of term newborns initiate spontaneous breathing independently, timely interventi...
- Health & MedicineOpen access
The 2025 Korean pediatric advanced life support guideline update introduces clinically important revisions emphasizing airway strategy, physiologic resuscitation targets, post-cardiac arrest hemodynamics, neuroprotection, and extracorporeal support. In out-of-hospital pediatric c...
- Health & MedicineOpen access
BACKGROUND: Mechanical ventilation requires repeated adjustment to changing patient physiology, but consistent individualized management remains challenging. We developed VentPilot, an artificial intelligence-based system for recommending ventilator settings, and evaluated it in...
- Health & MedicineOpen access
Pediatric cardiac arrest primarily arises from asphyxia in infants and trauma in older children, contrasting with adult etiologies dominated by cardiac events. This underscores prevention as the cornerstone of pediatric basic life support, through injury mitigation like child res...
- Health & MedicineOpen access
Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...
- Engineering & TechnologyOpen access
Textbooks, and computed tomography (CT) scans are traditional resources for anatomy education but may be insufficient for complex anatomy. This study evaluated whether adding three-dimensional printing (3DP) abdominal models to CT images improves learning of abdominal anatomy, in...
- Health & MedicineOpen access
Abstract Background: Premature ovarian insufficiency (POI) is a reproductive disorder characterized by the early loss of ovarian function before the age of 40, resulting in infertility and increasing the long-term risk of health issues such as osteoporosis, cardiovascular disease...