Seoul National University Hospital

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherap...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Perioperative outcomes of robot-assisted, laparoscopic or thoracoscopic, and open surgery across 13 cancer operations: a single-institution cohort of 36,208 cases

Abstract To compare perioperative outcomes of robot-assisted surgery, video-assisted (laparoscopic or thoracoscopic) surgery and open surgery across 13 oncologic procedure groups, because aggregate technology-level comparison is confounded by procedure mix and by the calendar tim...

Complex regional pain syndrome research trends

Background: Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by disproportionate regional pain and distinct clinical features such as allodynia and hyperalgesia. We conducted a bibliometric analysis to map the global research landscape of CRPS over t...

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...

Subtype‐specific immunophenotypic and cytogenetic patterns complement flow‐cytometric detection of measurable residual disease in B‐lymphoblastic leukemia

Measurable residual disease (MRD) is a key prognostic marker in B-lymphoblastic leukemia (B-ALL). Because immunophenotypic and cytogenetic features vary by genetic subtype and treatment phase, the clinical value of an integrated MRD strategy using multiparametric flow cytometry (...

Machine learning-assisted prediction of 5-year mortality in chronic kidney disease: the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)

Background: Mortality prediction models for patients with non-dialysis chronic kidney disease (CKD) remain limited despite their clinical importance. While machine learning (ML) offers the potential to improve prediction accuracy, its "black-box" nature has hindered clinical adop...

Validation of ring-type cuffless blood pressure (BP) monitoring device for detecting awake-asleep BP variations compared to ambulatory BP monitoring device

Abstract We evaluated the accuracy of a ring-type cuffless BP device (CART BP Pro) in detecting awake–asleep BP changes compared to conventional 24-h ambulatory BP monitoring (ABPM), following the validation protocol recommended by the European Society of Hypertension (ESH). Amon...

Plasma Metabolomes Identify Distinct Asthma Metabotypes: Findings From the COREA Cohort

BACKGROUND: Phenotype-based asthma classification has limitations that have motivated endotype-based approaches grounded in pathophysiology. However, existing biomarkers offer limited specificity and clinical accessibility. Plasma metabolomics, which reflects disease-specific met...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS)

Abstract Background The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to in...

Regional brain morphometric correlates of CT-defined metabolic dysfunction-associated steatotic liver disease and hepatic fat burden

Hepatic steatosis is the defining imaging feature of metabolic dysfunction-associated steatotic liver disease (MASLD) and is detected on abdominal CT. Whether CT-defined MASLD and hepatic fat burden are associated with brain morphometric variation beyond cardiometabolic and CT-de...

Living alone, socioeconomic status, and mortality among older adults: a population-based cohort study

This study examined the association between living alone, socioeconomic status, and mortality among community-dwelling older adults. We analyzed mortality outcomes among 3,771 participants aged ≥ 60 years enrolled in the Korean Longitudinal Study of Aging (KLoSA) beginning in 200...

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) arises from a bone remodeling imbalance in which osteoclast-mediated resorption exceeds osteoblast-driven formation. However, current therapies primarily target osteoclasts without restoring osteoblast function, underscoring the need for mechani...

Prospective Study of Targeted Busulfan–Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Genetic Rare Diseases

ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option. Conventional myeloablative...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...