Seoul National University

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Self-Monitoring Theranostic Nanomaterials for Biomedical Imaging and Cancer Therapy: Real-Time Visualization of Biodistribution, Payload Release, and Therapeutic Response

Theranostic nanomedicines integrate therapeutic delivery with diagnostic imaging, but many conventional platforms primarily visualize nanocarrier localization and provide limited information on whether the therapeutic payload has been released, the intended treatment mechanism ha...

Clinical Outcomes of Switching from Prostaglandin Analogs to Omidenepag Isopropyl in Primary Open-Angle Glaucoma and Glaucoma Suspect Patients with Prostaglandin-Associated Periorbitopathy: A Prospective, Multicenter Study

Background/Objectives: Prostaglandin-associated periorbitopathy (PAP) is a common treatment-related burden of prostaglandin analog (PGA) therapy that may compromise long-term glaucoma management. This study evaluated improvement in PAP and changes in intraocular pressure (IOP) af...

Nondestructive prediction of textural properties of model plant-based meat analogs prepared with sesame seed meal protein isolate using hyperspectral imaging

Abstract Texture, a key quality attribute in plant-based meat analogs (PMAs), is conventionally evaluated using destructive methods. This study evaluated the use of hyperspectral imaging (HSI) coupled with partial least squares regression (PLSR) for the nondestructive prediction...

Electroluminescence from bound excitons in silicon

We demonstrate a signature of bound-exciton emission in the electroluminescence spectra of wafer-bonded silicon p–n junction, along with the more common free-exciton emissions. The emission is driven by the electric current through a p–n junction formed by direct bonding of p-typ...

Modular van der Waals MOSFETs through layer-by-layer chalcogen substitutions

In two-dimensional transition-metal dichalcogenides (TMDCs), the local electrostatic field of the chalcogen p -orbitals dictates the crystal field splitting of the transition metal d -orbitals, stabilizing diverse electronic states from semiconducting and semimetallic to exotic t...

Observation-constrained assessment of long-term cropland productivity trends and drivers at the global scale

The cropland ecosystem is closely linked to global food security and carbon budget dynamics. Understanding the trends and drivers of cropland gross primary productivity (GPP) is essential for evaluating potential agricultural yields and for formulating effective adaptation and ev...

Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026

Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...

From coach trust to flow: Teamwork execution and teammate trust among Korean high school soccer players

This study examines the association between coach trust and flow among Korean high school soccer players by testing the mediating role of teamwork execution and the moderating role of teammate trust in this indirect relationship. The participants were 256 high school soccer playe...

Development and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential

Background: Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.Serine/ threonine-protein kinase 3 (STK3) and STK4 promote mitophagy, leading to reduced mitochondrial mass in adipose tissue.Thus, inhibition of STK3/4 represents a p...

High‐Resolution Temperature and Precipitation Variability in Northeast Asia Since the Last Glacial Maximum Recorded in an Annually Laminated Maar Lake

Abstract Temperature and precipitation variability in monsoonal Asia is central to understanding regional climate dynamics and global teleconnections. How post‐LGM warming and hydroclimate change unfolded in Northeast Asia, and how they were linked to external forcing, remain poo...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Metabolomic profiling and biomedical potential of adventitious roots derived from a 150-year-old mountain ginseng

Panax ginseng Meyer, sometimes known as Asian ginseng or Korean ginseng, is an important medicinal herb used in traditional medicine and health foods in Korea, China, and Japan. Ginsenosides, also known as saponins, are found in ginseng roots along with polysaccharides, peptides,...

PrOMet: Accurate and Robust Metal‐Binding Site and Type Prediction

ABSTRACT Metal binding to proteins is crucial for many biological functions, yet the prediction of metal‐binding sites and metal types remains underexplored compared to other biomolecular interactions. Despite advances in deep learning, computational methods have achieved limited...

Lymphocyte-predominant inflammation refines lung histopathology scoring in preclinical respiratory viral infection: support from deep learning analysis

Respiratory viral infections such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain major causes of morbidity and mortality. Although lung histopathology is a major endpoint in preclinical studies, conventional H&E-based grading primarily evalua...

Vertical NAND Flash Memory‐Based Bayesian Neural Networks With Intrinsic Gaussian Weight Sampling

Bayesian neural networks (BNNs) provide improved robustness and well‐calibrated uncertainty estimates compared with deterministic networks, but their hardware realization remains challenging because Gaussian weight sampling typically requires random number generators, substantial...

A staged clinical development and evidence-generation framework for Group A Streptococcus vaccines

Group A Streptococcus (Strep A) causes substantial global morbidity and mortality, yet vaccine development faces scientific, regulatory, and strategic challenges. We propose a platform-agnostic, staged clinical development and evidence-generation framework aligning trial feasibil...

Cardiac Reverse Remodeling and Clinical Outcomes Following Angiotensin Receptor‐Neprilysin Inhibitor Therapy in Heart Failure With Reduced Ejection Fraction

Background Cardiac reverse remodeling and associated clinical outcomes following angiotensin receptor‐neprilysin inhibitor (ARNI) therapy in patients with heart failure (HF) with reduced ejection fraction (EF) remain unclear. We investigated differences in 1‐year echocardiographi...

Protocol aware machine learning for prediction and selection of flooding recovery strategies in open cathode PEM fuel cells without recovery transient measurements

A protocol aware machine learning framework enables prediction and selection of flooding recovery strategies in open cathode PEM fuel cells without measuring the recovery transient. Four recovery modes, step-up, pulse-up, ramp-up, and short-circuit pulse, are characterized over 1...

Identifying technological problems and exploring potential solutions to support R&D: Tech-mining with multi-LLM applications

The shortening of technology lifecycles and growing technological complexity have made the rapid identification of technical problems and exploration of solutions a critical challenge. Patent analysis can serve as a crucial tool for supporting R&D activities by extracting problem...