Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Joint trajectories and associated characteristics of postpartum depressive and anxiety symptoms: a longitudinal study

Postpartum depressive and anxiety symptoms are common postpartum mental health issues, and these symptoms often co-occur. However, previous studies have primarily analyzed them separately, with limited evidence regarding their joint developmental trajectories and associated chara...

Association Between Preoperative Tea Drinking Habits and Postoperative Ileus in Colorectal Cancer Patients: A Propensity Score-Matched Study

Objective This study evaluated whether preoperative tea consumption reduces postoperative ileus risk after colorectal cancer surgery, given tea’s anti-inflammatory and antioxidant properties. Methods In this retrospective cohort of 681 patients, tea drinkers (≥1 cup/day, n = 191)...

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

ABSTRACT Postmenopausal osteoporosis is caused by excessive osteoclast‐mediated bone resorption. This study identifies mitochondrial oxidative phosphorylation (OXPHOS) as a tractable metabolic target for antiresorptive therapy. A literature‐guided drug repurposing screen focused...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

X-Linked Agammaglobulinemia with De novo BTK Mutations in Chinese Children: A Case Report and Literature Review

X-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency caused by Bruton’s tyrosine kinase ( BTK ) mutations that lead to defective B-cell development and severe antibody deficiency. This study aimed to describe a novel de novo BTK mutation in a Chinese child and sum...

Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010–2024)

Invasive pneumococcal diseases (IPD) are among the leading causes of global child mortality. Pneumococcal conjugate vaccines provide direct protection against IPD caused by serotypes included in the vaccine. To investigate the clinical characteristics, serotypes, and antibiotic r...

The natural course of pediatric epididymal cysts during puberty: resolution trends and predictive value of baseline size

Epididymal cysts represent a frequent benign scrotal finding in boys, yet their natural history throughout the pubertal transition remains insufficiently understood. Current clinical guidance is largely derived from adult data, and objective predictors of spontaneous regression d...

Autism spectrum disorder burden in China and worldwide, 1990–2021

Autism spectrum disorder (ASD) imposes a substantial public health burden. This study quantified and compared the ASD burden in China and globally from 1990 to 2021 to inform policy and planning. We analyzed Global Burden of Disease 2021 estimates of age-standardized prevalence r...

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

pH-responsive resveratrol delivery using chitosan-based nanoparticles embedded in GelMA: in vitro evaluation of acute brain injury-relevant cellular responses

Secondary injury after acute brain injury (ABI) involves interconnected oxidative, inflammatory, and apoptosis-associated cellular responses. Resveratrol (RSV) has antioxidant and anti-inflammatory activities, but its limited aqueous stability and rapid clearance restrict sustain...

Investigating the divergence of β-lactamase PDC variants conferring various antibiotic resistance profiles in Pseudomonas aeruginosa, coupled with the molecular profiling of PDC-266

Pseudomonas aeruginosa is a critical pathogen in hospital-acquired infections, with resistance primarily mediated by chromosomally encoded blaPDC alleles. While wild-type PDCs typically hydrolyze penicillins and cephalosporins, specific amino acid substitutions can broaden their...

Multi-Scale MRI, Radiology Reports, and Blood Biomarker–Guided Multimodal Deep Learning for Predicting Postoperative Recurrence in Cervical Cancer: A Multicenter Study

Objectives: Cervical cancer (CC) remains a leading cause of cancer-related morbidity and mortality among women worldwide, with postoperative recurrence posing a major challenge to long-term survival. Multimodal data integration, including imaging, textual, and clinical informatio...

Pulmonary Tropheryma whipplei infection in a patient with systemic lupus erythematosus: diagnosis supported by BALF tNGS with subsequent doxycycline-based treatment: a case report

Whipple’s disease is a rare systemic infection caused by Tropheryma whipplei ( T. whipplei ). Pulmonary involvement is uncommon and may mimic sarcoidosis, tuberculosis, or malignancy, delaying diagnosis. Pulmonary presentations may be atypical and nonspecific. We report the case...

Colposcopic Imaging Carries Most of the Signal: Externally Validated Tri-Modal Integration of Imaging, Vaginal Microbiome, and Coagulation-Immune Data in HPV-Associated Co-Infection

Background/Objectives: To determine whether a coagulation-immune index, vaginal microbiome composition, and colposcopic imaging carry non-redundant information about HPV-associated lower genital tract co-infection when integrated within a single learned model. Methods: This retro...

Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics

ABSTRACT Background Sarcopenia is a common condition in patients with gastric cancer that is associated with poor survival and adverse clinical outcomes. Conventional diagnostic approaches are time‐consuming, limiting large‐scale clinical implementation. This study aimed to devel...

Clinical and imaging characteristics of cervical ossification of the posterior longitudinal ligament and factors influencing its severity: a retrospective cross-sectional study

Abstract Background Although the prevalence of cervical ossification of the posterior longitudinal ligament (OPLL) and its risk factors for onset and postoperative progression have been well documented, a comprehensive profile of patients with this condition remains lacking, and...

Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease

Fibroblast growth factor-23 (FGF23) has been linked to adverse cardiovascular phenotypes, yet its prognostic relevance among individuals with prevalent cardiovascular disease and the potential modifying role of kidney function remain unclear. We analyzed 9,119 UK Biobank particip...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...