Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...

Dynamic 5-hydroxymethylcytosine remodeling associated with synaptic gene programs in the striatum of a Parkinson’s disease mouse model

The striatum, a key structure within the basal ganglia, undergoes functional dysregulation following the loss of dopaminergic input, contributing to the motor symptoms of Parkinson’s disease (PD). However, the involvement of DNA hydroxymethylation in striatal dysfunction remains...

An impaired excitatory-inhibitory balance in the right inferior temporal gyrus of patients with Alzheimer's disease correlated with executive function

Preliminary research indicates that an imbalance between excitation and inhibition may be an early pathological feature of Alzheimer's disease. However, the relevant brain networks, neurotransmitters and genetic mechanisms are still unclear. This study enrolled 27 patients with A...

Surgical case order is associated with postoperative infection risk in total knee arthroplasty

Total knee arthroplasty is regarded as the most effective treatment for severe knee joint problems. Surgery case order influences operative outcomes according to previous studies. This study aims to evaluate the effect of surgical case order on operative outcomes for TKA. A retro...

Epidemiological Characteristics of Pediatric Drug Poisoning in Wenzhou, China in 2017–2024

To examine the evolving epidemiological characteristics of pediatric drug poisoning in Wenzhou, China from 2017 to 2024, focusing on temporal trends, age/sex-specific risks, and changes in poisoning intent and toxin types, and to generate evidence-based guidance for targeted prev...

Agentic echocardiography report structuring for cardiovascular prediction and disease association discovery

Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...

Derivation of a novel risk assessment model of venous thromboembolism in hospitalized patients

Background Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), significantly contributes to morbidity and mortality among hospitalized patients. Despite the existence of various VTE risk assessment models (RAMs), their performance...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...

The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

Background and Purpose Previous studies have highlighted the significance of the bile acid receptor TGR5 (also known as Takeda G protein‐coupled receptor 5) in regulating inflammation and mitochondrial homeostasis in various diseases, whereas the specific involvement of TGR5 in s...