Sanya University

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple genes. However, achieving high‐efficiency simultaneous editing at multiple loci remains challenging for cytosine base editors (CBEs), largely due to va...

Environmental heterogeneity shapes divergent assembly processes and network stability of plankton communities along a tropical island coast: Evidence from Hainan Island

Understanding how plankton communities respond to environmental heterogeneity is essential for assessing tropical island coastal ecosystems and supporting region-specific management. Based on data from 59 environmental monitoring stations, including 16 stations with plankton samp...

Immunogenicity and protective efficacy evaluation of an inactivated Lawsonia intracellularis vaccine candidate developed on the basis of a Chinese isolate in pigs

Abstract Porcine proliferative enteropathy (PPE), caused by the obligate intracellular bacterium Lawsonia intracellularis (LI), is an important enteric disease of pigs that impairs intestinal function and growth performance. Vaccination is the most effective measure for the preve...

Polycomb protein ZmEMF1a restricts endosperm proliferation and directs differentiation via stage‐specific H2Aub1 and H3K27me3 landscapes in maize

Polycomb group (PcG) proteins serve as pivotal epigenetic repressors that govern the transcriptional programs underlying cell growth and differentiation. However, their functional roles in maize endosperm remain largely unexplored. Here, we characterize the recessive maize small-...

Depleting luminal cysteine with engineered bacteroides vulgatus alleviates experimental colitis by suppressing Th17 differentiation through an ATF6-dependent mechanism

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by dysregulated immune responses, particularly the aberrant activation of T helper 17 (Th17) cells. While microbiome-based therapies show promise, wild-type probiotics often lack specific m...

Learning to sail without wind information: reinforcement learning-based control for unmanned sailing vessels under partial observability

Unmanned sailing vessels commonly rely on real-time wind-field measurements as key inputs for multi-level decision-making, including path planning and control. During long-endurance offshore missions, however, wind-sensing systems may be affected by harsh environmental conditions...

Calcium: A Pivotal Regulator of Panicle Apical Abortion in Rice

Panicle size is a critical determinant of grain yield in rice and other cereal crops. During rice growth and development, panicle apical abortion (PAA) frequently occurs, particularly under unfavorable conditions, resulting in a reduced number of fertile spikelets and substantial...

ExMODE: A comprehensive resource for extremophile genomic and functional exploration

ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 biosynt...

Solanaceous-Vegetable Price Volatility and Producer Operating Income in China: Evidence from Three Production-Side Response Indicators

Solanaceous vegetables are fresh and perishable, are marketed in concentrated periods, and require production decisions to be made in advance; consequently, fluctuations in the price path can alter producers’ cash-flow arrangements, input schedules, and risk exposure. Using a bal...

ZcKr-h1 Knockdown Impairs Female Reproduction and Lifespan in Zeugodacus cucurbitae Under Normal and Short-Term High Temperature

Short-term high temperature is a critical environmental factor affecting the population dynamics of invasive insect pests. Krüppel-homolog 1 (Kr-h1) is a key transcription factor involved in insect reproduction. In this study, we investigated the role of ZcKr-h1 in female reprodu...

Rhizosphere Microbiome Characteristics of Grafted Watermelon and Own-Rooted Watermelon Under Continuous Cropping Soil Conditions

Continuous cropping in tropical protected cultivation can impair soil health and increase the risk of soil-borne disease. We conducted a single-season field comparison in Hainan (October 2025–February 2026) to characterize the performance and rhizosphere microbial profiles of the...

A Hybrid CNN-Transformer Network for Linear Noise Suppression in 3D Seismic Data

Abstract 3D seismic data acquisition, processing, and analysis have become increasingly prevalent in modern geophysical exploration. However, various types of coherent noise, especially linear noise, can cause serious interference and effective noise reduction techniques are crit...

Comparative Safety Assessment of Solid Gravity Energy Storage Pathways Using the Analytic Hierarchy Process

Solid gravity energy storage (SGES) has emerged as a promising long-duration energy storage option, but systematic safety comparisons among its principal technology pathways remain limited. This study develops a unified expert-based framework for the comparative safety screening...

AI-driven discovery of self-assembled antimicrobial peptides with dual antibacterial and wound-healing functions against multidrug-resistant infections

The rapid emergence of multidrug-resistant bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus and carbapenem-resistant Acinetobacter baumannii , poses a critical challenge to global healthcare. Antimicrobial peptides (AMPs) are promisin...

Hotspot to Homogeneous: Amorphous Interfacial Current Redistribution Enables Stable Solid-State Lithium-Metal Batteries

Abstract Interfacial instability in oxide ceramic electrolyte (OCE)-based solid-state lithium metal batteries (SSLMBs) is conventionally attributed to chemical incompatibility or mechanical failure, yet the underlying atomic-scale mechanisms remain elusive. Here, we reveal that g...

Comparative genomics of the streptococcal mobilome reveals class-specific integration, mobility and antimicrobial resistance cargo

Abstract Mobile genetic elements (MGEs) drive genome plasticity, horizontal gene transfer, and antimicrobial resistance (AMR) dissemination in Streptococcus , yet genus-wide comparisons across major MGE classes remain limited. Here, we analyzed 1,961 complete genomes from 60 Stre...

Anomalous deformation behavior and underlying mechanisms of Mg-Nd-Zr-Ca alloy during low-temperature hot compression

The anomalous deformation behavior of a Mg-1.8Nd-0.4Zr-0.3Ca (wt%) alloy during hot compression at low temperatures (180–330 °C) and strain rates of 0.001–10 s⁻¹ was systematically investigated. The flow stress exhibits an abnormal increase with decreasing strain rate at 180 °C,...

A New Understanding of Stratigraphic Development in Subsurface Arid Alluvial Fans: Implications From the Northwest Margin of the Junggar Basin, China

ABSTRACT Alluvial fans are common sedimentary deposits on Earth and serve as crucial reservoirs for underground oil and gas. However, our understanding of the stratigraphic development and sedimentary evolution of different alluvial fan types remains limited. This study examines...

Chinese Painting Semantic Resource for Resolution-Aware Digitisation and Structured Heritage Access

Chinese painting digitisation poses a distinctive heritage-informatics challenge: culturally salient visual structures such as brushwork, intentional blank space, and text–image coexistence are difficult to document, access, and research with general-purpose collection and comput...

Soil Carbon Fractions and Aggregation Regulate N 2 O Emissions and Microbial N‐Cycling Genes: A Case Study Across Tropical Paddy Soils With Contrasting Organic Matter Levels

ABSTRACT Background : Nitrous oxide (N 2 O) is a major greenhouse gas, and its production is shaped by soil organic matter (SOM). Yet, how different SOM‐derived labile carbon fractions regulate N 2 O remains unclear, especially in tropical paddy soils where weak SOM stabilization...