Renji Hospital

A novel peptide interacts with RPL8 to alleviate portal hypertension by promoting ferroptosis

Liver fibrosis and mortal consequence of portal hypertension (PHT) is driven by hepatic stellate cells (HSCs) activation and their limited-explored property against elimination. We uncovered that HSC activation decreased the sensitivity to ferroptosis. By Ribo-seq, we identified...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

Longitudinal profiling of urinary extracellular vesicle RNA reveals physiological variability and stable reference genes in healthy individuals

Urinary extracellular vesicles (uEVs) have emerged as promising non-invasive molecular carriers for biomarker discovery, yet the physiological variability and tissue-associated characteristics of uEV RNA cargo in healthy individuals remain poorly defined. This knowledge gap limit...

Supramolecular immunomodulatory hydrogelator potentiates CAR-T therapy with long-lasting endogenous immunity toward solid tumor eradication

The success of chimeric antigen receptor (CAR)-T cell therapy in hematologic malignancies has not been translated to solid tumors, primarily due to inadequate T cell infiltration and an immunosuppressive tumor microenvironment that drives T cell exhaustion. To address these chall...

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

ABSTRACT Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism regulating polarized cellular and tissue behaviors in diverse morphogenetic and physiological processes. Disruption or aberrant activation of PCP signaling can cause developmental defects or pr...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

Leukocyte glycemic index associated with 30-day mortality in sepsis patients with new-onset atrial fibrillation: insights from the MIMIC-IV database

This study aimed to examine whether the leukocyte glycemic index (LGI), a compact marker linking inflammatory burden with stress-related glucose disturbance, is associated with 30-day mortality among patients with sepsis complicated by new-onset atrial fibrillation (NOAF). This r...

DNA framework-enabled pathogen detection

The rapid and accurate detection of pathogenic microorganisms is essential for controlling infectious diseases and protecting public health. Traditional methods, including microbial culture, immunoassays, and polymerase chain reaction (PCR), are limited by long turnaround times,...

Tissue engineering scaffolds for the spinal cord: recent advances and future prospects

Spinal cord tissue engineering scaffolds represent a highly promising option for the treatment and repair of spinal cord injury (SCI). They have a wide range of potential applications and, as essential biomaterial carriers, can restore the multifunctional microenvironment. Since...

Optimization of Minocycline‐Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Randomized Controlled Trial

ABSTRACT Background and Aim Minocycline‐containing bismuth quadruple therapy may provide a practical option for Helicobacter pylori ( H. pylori ) rescue treatment when tetracycline is unavailable, yet the optimal dosing remains unclear. We aimed to compare the efficacy and safety...

Occurrence, recurrence, and prognosis of hyperkalaemia in a large real-world cohort

Abstract Background Hyperkalaemia (HK), a common electrolyte abnormality, often occurs in patients with other comorbidities. This study assessed the occurrence, recurrence, and prognosis of HK in a real-world setting. Methods In this single-center, retrospective study (January 20...

PSMD11 promotes hepatocellular carcinoma progression by reprogramming lipid metabolism via SREBP1/2 and PPAR-γ

Abstract Dysregulation of the ubiquitin-proteasome system (UPS) plays a pivotal role in tumor progression. PSMD11, a non-ATPase regulatory subunit of the 26S proteasome, has been implicated as an oncogenic factor in several cancer types; however, its precise biological function a...

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Changing trends in the clinical characteristics of gastrointestinal bleeding among hospitalized patients from 2012-2024 in China: a retrospective study

Gastrointestinal bleeding (GIB) remains a critical medical emergency with rising healthcare burdens in China. This study aimed to analyze its epidemiological shifts and risk factors over the past decade. A retrospective analysis included 3,523 inpatients with GIB at Renji Hospita...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Organizing Large GTPase Atlastin‐Mediated Membrane Fusion by Programmable DNA Origami Platforms

ABSTRACT In eukaryotic cells, the endoplasmic reticulum (ER) utilizes membrane fusion to form interconnected networks. GTP hydrolysis‐triggered conformational changes in ER‐anchored atlastins (ATLs) have been shown to be responsible for this process, which is facilitated by the a...

Defect Engineering of DNA Origami ROS Sensors for Portable Urinalysis

ABSTRACT Translating in situ dynamic changes of key signaling molecules into actionable clinical readouts remains a formidable challenge for noninvasive diagnostics. Here, focusing on reactive oxygen species (ROS) as pivotal signaling mediators, we developed defect‐programmed DNA...

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections

CD8 T cells are critical players in immune responses against pathogens. Interleukin-21 (IL-21) is predominantly produced by CD4 T cells and exerts multifaceted effects on CD8 T cell regulation and function. Using Il21 -reporter and Il21 –fate mapping mice, we report that a subpop...