Renji Hospital

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Associations between non-insulin-based insulin resistance surrogates and pulmonary hypertension due to left heart failure: a multicenter cohort study

Abstract Background Insulin resistance (IR) has been reported to have a close relationship with the development and adverse outcomes of various cardiovascular disorders, while its association with pulmonary hypertension due to left heart failure (PH-HF) remains to be elucidated....

Response to the Correspondence Regarding “Cutaneous Metastasis From Papillary Thyroid Carcinoma Eight Years After Initial Surgery”

ABSTRACT We sincerely thank Dr. Sengul and colleagues for their insightful comments on our case report of skin metastasis in papillary thyroid cancer (PTC). They questioned the adequacy of local excision and suggested completion thyroidectomy to enable radioactive iodine (RAI) th...

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Disitamab vedotin triggers ferroptosis to activate CD8+ T-cell antitumor immunity in HER2-expressing breast cancer

Abstract Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and is associated with poor prognosis after metastasis or recurrence. The development of anti-HER2 antibody–drug conjugates (ADCs) has markedly improved outcomes. Disitamab vedoti...

TAMs-derived exosomal PD-L1 drives mitochondrial dysfunction and aberrant fatty acid oxidation via PGC-1α/PPARα axis to promote peritoneal metastasis in epithelial ovarian cancer

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the ovarian cancer peritoneal microenvironment; however, how their exosomes metabolically reprogram CD8⁺ T cells to induce dysfunction and promote peritoneal metastasis remains unclear. M2-type TAMs were in...

NAT-A exhibits anti-tumor activity against acquired epidermal growth factor receptor- tyrosine kinase inhibitor-resistant non-small cell lung cancer via inhibiting the β-catenin/PKM2 axis

Hyperactivation of the Wnt/β-catenin pathway is a key driver of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance in non-small cell lung cancer (NSCLC), with pyruvate kinase M2 (PKM2) serving as a critical transcriptional coactivator of β -catenin....

Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing

Anxiety is clinically associated with impaired fracture healing, but the underlying immunological mechanism remains unclear, and no targeted therapy is available. In a mouse model of chronic restraint stress (CRS)-induced anxiety with femoral fracture, we observed expansion of TG...

Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions

Importance Cancer risk is higher in males than females globally. Whether this sex disparity reflects a biological inevitability or is potentially modifiable by lifestyle behaviors and health conditions across diverse populations remains unclear. Objective To determine the contrib...

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance

The rational design of nanomedicines is fundamentally constrained by a physicochemical paradox at the bio-nano interface: strategies to prolong circulation inevitably suppress clearance, often resulting in long-term accumulation and systemic toxicity. To address this, we propose...

Enhanced production of phomapyrrolidone a through culture-condition optimization and morphological regulation in Didymella sp. FATR0054

Phomapyrrolidone A (Ppd A) is a hirsutellone-type macrocyclic alkaloid derived from marine fungi, exhibiting significant activity against triple-negative breast cancer (TNBC). However, its low fermentation yield has limited further drug development. This study established a syste...

CGA-DTA: interaction-conditioned graph topology and cross-graph attention for drug--target affinity prediction

Drug–target affinity (DTA) prediction supports virtual screening in computer-aided drug discovery, but graph-based models still face two linked limitations. Adaptive-topology methods usually learn drug and protein graphs independently and merge them only at the prediction head, w...

Overweight/Obesity and Hyperinsulinemia Impair Oocyte Developmental Competence via Cumulus Cell Dysfunction and Oxidative Stress-Mediated Follicular Microenvironment Remodeling

Overweight and obesity, frequently accompanied by hyperinsulinemia, are established risk factors for female infertility. Cumulus cells (CCs) are hypothesized to play a crucial role in this etiology, yet the underlying mechanisms remain largely elusive. In the current study, we in...

Single-cell transcriptomics landscape decodes cardiac fibroblast heterogeneity and reveals PDK4-driven profibrotic activation during cardiac fibrosis

Cardiac fibroblasts act as a key driver of myocardial fibrosis across various heart diseases, but the recently recognized heterogeneity within fibroblast populations has hindered mechanistic understanding. This study aimed to investigate the heterogeneity of cardiac fibroblasts a...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...