Radboud University Medical Center

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa

Host-microbe interactions in the upper respiratory tract (URT) niches that form the first line of defense against respiratory infections are incompletely understood. We profiled immune and microbial features using minimally invasive samples from 44 healthy adults (20–65 years), i...

Associations of frailty and COVID-19 severity with long-term health outcomes of COVID-19 among older people

To investigate whether frailty and COVID-19 severity are associated with long-term health outcomes of COVID-19 in older people. In this cohort study, older people aged ≥ 70 years with COVID-19 between January 2020 and December 2021 were invited for follow-up. Participants were re...

Two-year impact of a bundled payment program for total hip or knee replacement in the Netherlands: a difference-in-differences analysis

Abstract Background In 2018, a Dutch health insurer introduced a bundled payment program for total hip or knee replacement (THKR). Participating hospitals shared in savings and losses per episode, covering all THKR-related hospital care, including complications within one year af...

Temporal evolution of vessel wall abnormalities in young ischemic stroke – the ODYSSEY study

INTRODUCTION: We examined the temporal patterns of vessel wall (VW) lesions on high-resolution MRI (HR-MRI) in a cohort of young stroke survivors. STUDY AND METHODS: This substudy of the ODYSSEY is a single-center prospective cohort study comprising participants aged 18-50, who e...

Blended Care in the mCIMT-BiT Pirate Group in Children with Unilateral Cerebral Palsy: A Feasibility Study

Aims Intensive upper limb rehabilitation is essential for children with unilateral cerebral palsy (uCP). Home-based training may extend practice opportunities and reduce logistical barriers. This study examined the feasibility of a blended care approach in the mCIMT-BiT Pirate gr...

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

Reliability, validity, and change over time in disinhibited and disruptive behaviors assessed with the age‐adapted disruptive behavior diagnostic observation schedule in children aged 5–12 years with ADHD

Abstract Background Previous research has shown that the disruptive behavior diagnostic observation schedule (DB‐DOS) is a valid and reliable clinic‐based assessment of disinhibited and disruptive behaviors in preschoolers. We adapted the DB‐DOS for use in children aged 5–12 year...

A Systematic Review (and Meta-Analysis) and Global Expert Consensus Statements (U-POP): The Manchester Procedure

Abstract Introduction and Hypothesis The Manchester procedure (MP) is the oldest uterus-sparing technique for uterine prolapse and has traditionally been used to treat cervical elongation (CE). However, its optimal application remains unclear. This review aimed to evaluate the be...

Cross-national clinical exchange in child psychiatry across cultural contexts and mental health systems: a scoping review

Abstract Background Clinical practice in child and adolescent psychiatry (CAP) relies on internationally shared, empirically grounded guidelines, yet their application is influenced by socioeconomic and cultural differences. Cross-national clinical exchange allows health professi...

Effects of GLP-1 receptor agonists on body weight and cardiovascular outcomes: a review

Obesity is a rapidly increasing global health challenge that is strongly linked to the cardiorenometabolic syndrome, cardiovascular morbidity, and mortality. Lifestyle interventions remain the cornerstone of treatment, but average long-term weight loss is modest and durable weigh...

DUTCH weight control in atrial fibrillation study (DUTCH-WAIST)

Abstract Background Obesity is a well-established and highly prevalent risk factor for atrial fibrillation (AF) and its progression by promoting structural and electrical atrial remodelling, leading to AF recurrence and persistence. Weight loss is expected to reverse atrial remod...

Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity

Abstract The global prevalence of overweight and obesity has increased markedly over recent decades. In clinical obesity care, and in the management of other chronic conditions, the role of physical exercise has largely been evaluated in the context of weight loss. Yet, while it...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Bone morphology influences asymptomatic knee kinematics across the flexion range: a dynamic CT study

Considerable inter-individual variability in knee kinematics exists even within asymptomatic populations, yet the extent to which this variability relates to underlying morphology remains poorly understood. This study aimed to identify morphological features associated with asymp...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Supporting clinical guidelines for opioid conversion to methadone and tapering to prevent withdrawal in critically ill children using physiology based pharmacokinetic modeling and simulation

Long-term opioid use is common in critically ill children and can cause withdrawal symptoms at discontinuation. To avoid withdrawal, short-acting opioids are usually converted into a long-acting drug, such as methadone, which is then carefully tapered. However, the exact conversi...

Low-Dose Naltrexone in Crohn’s Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit

Crohn’s disease (CD) is often refractory to standard therapies, and patients are sometimes reluctant to initiate immunosuppressive therapy, prompting interest in novel treatments such as low-dose naltrexone (LDN). To evaluate the efficacy of LDN for induction of remission in pati...

Video-based quantification of leg agility in Parkinson’s disease and its relationship to upper extremity motor impairments

Abstract Bradykinesia is a hallmark sign of Parkinson’s disease (PD). Current clinical assessment is susceptible to inter-rater variability and only provides a single, ordinal severity score. Here, we propose a computer vision-based framework to quantify distinct motor characteri...

The Key Factor Toxicity: development and application of a toxic pressure characterization tool for surface and drinking water

The European Water Framework Directive (WFD) aims to ensure a status with sufficient good-quality water to sustain ecosystems and drinking water production. Water quality is, however, affected by complex mixtures of polluting substances, whose combined effects are poorly captured...