Radboud University Medical Center

Linking nasopharyngeal and oropharyngeal microbiota to immune responses during influenza-like illness in an aging population

Older adults are vulnerable to influenza-like illness (ILI). To study how infection shapes the respiratory microbiota, we profiled nasopharyngeal (NP) and oropharyngeal (OP) communities alongside local immune mediators in adults aged 60–88, comparing asymptomatic, ILI, and recove...

Implementation of a Guideline-Based Preference Elicitation Tool to Enhance Shared Decision-Making in Supervised Exercise Therapy for Patients With Intermittent Claudication: A Multi-Methods Cluster Randomized Trial

Abstract Importance Shared decision-making is not yet common practice in physical therapy, emphasizing the need for effective decision aids. A preference elicitation tool (PE-tool) was designed to complement supervised exercise therapy (SET) in intermittent claudication treatment...

Self-reported memory strategy use following acquired brain injury

INTRODUCTION: Neuropsychological rehabilitation following acquired brain injury (ABI) often involves interventions teaching individuals with ABI strategies to compensate for memory impairment. However, little is known about spontaneous memory strategy use (i.e. without treatment)...

Investigating the transfer of physical stimuli to the dreamed body: A comparative study of muscular, vestibular, and haptic stimulation on dream incorporation

The relationship between the dreamed body and the physical body remains an open question in sleep and dream research. This study examined whether somatosensory stimulation applied during REM sleep modulates the corresponding dream content under controlled conditions. Using a with...

Hemocytometric Parameters Associated with Bacterial and Viral Etiology in COPD Exacerbations: An Exploratory Analysis

Exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) are often triggered by bacterial and viral infections, yet current diagnostic methods are time-consuming and biomarkers (e.g. C-reactive protein (CRP)) show limited accuracy in differentiating between these triggers....

Health-related interpretation of human biomonitoring results – new and updated human biomonitoring guidance values from PARC and HBM4EU

During the first three years of the Partnership for the Assessment of Risks from Chemicals (PARC), we derived health-based human biomonitoring guidance values (HBM-GVs) for 11 substances to enable the direct health-related interpretation of human biomonitoring (HBM) results. HBM-...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Anxiety state-related task disengagement varies with trait anxiety

Cognitively demanding tasks are often perceived as costly, leading to effort avoidance, particularly in populations with motivational impairments. Research on anxiety and cognitive effort are mixed: some suggest anxiety increases effort cost, while others indicate it can motivate...

Renal trauma in a pediatric Level 1 trauma center: morbidity, mortality, and the role of renal scintigraphy

Abstract Purpose Pediatric renal trauma is uncommon but potentially serious, and is often managed conservatively. Complications may occur, and the clinical value of renal scintigraphy during follow-up remains unclear. This study aimed to assess morbidity and mortality after pedia...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Dynamic Observation of Lacy Pattern Formation in a Bone Tissue Model Using Liquid Phase Scanning Transmission Electron Microscopy

ABSTRACT Bone is a hierarchical composite in which carbonated hydroxyapatite platelets form a continuous mineral network within and between collagen fibrils. Although the nanoscale organization of mature bone is well characterized, how mineral precursors transform into this archi...

Ultrasound- and fluoroscopy-guided hip aspiration before revision total hip arthroplasty: procedural outcomes and diagnostic accuracy in sequential cohorts

BACKGROUND AND PURPOSE: Hip aspiration remains essential in the diagnostic work-up of a painful total hip arthroplasty (THA) to assess for periprosthetic joint infection (PJI). In 2020, our institution transitioned from fluoroscopy-guided to ultrasound-guided aspiration. Our stud...

Impacting Rare Diseases Healthcare by Case‐Based Telelearning: Description of the Dutch Pilot Metabolic Diseases ECHO

ABSTRACT Inherited metabolic diseases (IMDs) are individually (ultra)rare but collectively relatively common. The Extension for Community Healthcare Outcomes (ECHO) model has been used worldwide since 2003 to disseminate knowledge and best practices in chronic diseases. In 2024,...

Controlling Linear and Non‐Linear Mechanics in Multicomponent Hydrogels Through Programmable Supramolecular and Covalent Interactions

ABSTRACT In our native extracellular matrix (ECM), hierarchical interactions—supramolecular and covalent—between multiple components give rise to complex mechanical properties. Reproducing such emergent properties in synthetic hydrogels remains challenging, particularly the non‐l...

Performance-based assessments in higher education: How ethnic background impacts stakeholders’ fairness perceptions of structured versus unstructured assessment methods

Performance-based assessments (PBAs), like literature reviews, evaluate students’ professional skills (e.g., analytical thinking). However, unclear evaluation criteria in PBAs lead to grading inconsistencies and biased outcomes. This diminishes perceptions of fairness among stake...

Plant functional type composition drives summer carbon cycling in an ombrotrophic peatland

Abstract Peatlands are globally important carbon sinks because plant CO 2 uptake outweighs microbial decomposition. These ecosystems are characterised by a distinct microtopography of hummocks and lawns, supporting vegetation communities composed of various plant functional types...

The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis

Abstract Cytochrome c oxidase (CIV) and ATP synthase are part of the oxidative phosphorylation machinery. Their modular, highly regulated assembly requires specific factors and is coordinated through a common intermediate, the Atco complex, composed of the Atp9 ring and Cox6. By...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...