Radboud University Medical Center

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

P1.157. International Comparison of Clinicopathologic Characteristics and Outcomes After Minimally Invasive transCervical Esophagectomy (MICE): A Retrospective Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally Invasive transCervical Esophagectomy (MICE) avoids a thoracic approach via transcervical mediastinal and abdominal dissection. Preserving pleural integrity may reduce pulmonary complica...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

When networking pays unequally: proactive personality, gender and career satisfaction in Vietnam and the United States

Purpose This study investigates how proactive personality shapes employees’ career networking and career satisfaction across two national contexts and whether the career returns to networking differ by gender. Drawing on the social role theory, we argue that proactive employees a...

A roadmap for standardization of serum albumin measurements

Abstract Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Un...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

Antimicrobial stewardship in practice: determinants of prescription behaviour and developing interventions to improve surgical prophylaxis in a Rwandan tertiary hospital—a mixed methods study using the behaviour change wheel

BACKGROUND: Behavioural sciences should be used to design and improve antimicrobial stewardship (AMS) interventions aiming surgical prophylaxis (SP). METHODS: A mixed-methods study at the University Teaching Hospital of Kigali, Rwanda. The study included an audit on SP practices...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine

Abstract Modern medicine increasingly extends beyond treating disease to supporting individuals through recovery, adaptation, and long-term functioning, all central to the concept of resilience. Despite growing interest, resilience remains conceptually difficult to structure and...

A Comprehensive Methodology for Estimating Yearly Plastic Pollution Loads in Rivers

Abstract Plastic pollution in freshwater systems represents a major global concern, as rivers serve as critical pathways between land-based sources and marine environments. Yet, inconsistencies are observed between estimated plastic inputs from land and concentrations in the ocea...

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

ABSTRACT The navigation and control of untethered magnetic robots (UMRs) within soft brain tissue critically depend on their ability to maintain synchronized rotation under applied rotational magnetic fields. The fundamental upper limit of this magnetic synchronization, known as...

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

ABSTRACT Purine crystals, such as guanine, generate diverse optical phenomena in animals and function as important nitrogen‐storage reservoirs in microalgae. Here, we demonstrate the formation of guanine crystals in Brewer's yeast. Whilst guanine crystals do not naturally contrib...

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

Abstract Objectives The high psychological burden of inflammatory bowel diseases (IBD) underscores the need for effective and feasible psychological treatment options. This study aimed to explore the acceptability and feasibility of mindfulness-based cognitive therapy (MBCT) for...

LncPNdeep: A long non-coding RNA classifier based on large language model with peptide and nucleotide embedding

Abstract Long non-coding RNA plays an important role in various gene transcription and peptide interactions. Classifying lncRNAs from coding RNA is a crucial step in bioinformatics analysis which seriously affects the post-analysis for transcriptome annotation. Although several m...

Prevalence and Correlates of Non-Prescribed Methylphenidate Use: A Cross-Sectional Study in Dutch University Students

Background Methylphenidate, prescribed for ADHD, is also used without prescription by students to enhance cognitive performance. While correlates of non-prescribed methylphenidate (NPM) use have been identified, few studies compared recent and former use across domains. This stud...

Photo‐Activated Merging Cascades in Droplet Swarms Upon Synergistic Solvation of Surfactants

ABSTRACT Chemically active droplets at fluid interfaces provide versatile building blocks for dynamic matter, yet most systems are limited to behavior encoded within individual droplets or simple pairwise interactions. Here, we report a strategy to generate non‐linear, cascading...

The Dutch Prolactinoma Cohort Studies: Cross-sectional Analysis of Females Focusing on the Patient's Perspective

Abstract Purpose To assess the results of patient-reported outcome measures (PROMs) in a national cohort of females with a prolactinoma by disease activity. Methods Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patien...

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...

Soft-tissue thickness changes following bimaxillary surgery in skeletal class II malocclusion

OBJECTIVES: This retrospective cohort study evaluated regional facial soft-tissue thickness changes after bimaxillary surgery in skeletal Class Ⅱ patients and assessed their associations with skeletal movement and patient-related factors. MATERIALS AND METHODS: Class Ⅱ patients t...