Radboud University Medical Center

Prevalence and outcome of metastases to the thyroid gland: a nationwide database study

OBJECTIVE: Metastases to the thyroid are seen relatively often in autopsy studies. In clinical studies they are described as a rare occurrence. This study aims to provide a more extensive representation of the origin, timing and survival of patients diagnosed with metastases to t...

Patients’ and clinicians’ perspectives on telemedicine to monitor patients on systemic treatment for psoriasis or atopic dermatitis - a mixed methods study

Background For patients with stable psoriasis or atopic dermatitis (AD) receiving systemic treatment, telemedicine may offer a viable alternative to in-person consultations. However, perspectives of these patients and dermatological care providers (DCPs) regarding telemedicine ar...

Clinical practice on treatment of primary traumatic anterior shoulder dislocation: a multidisciplinary guideline

BACKGROUND AND PURPOSE: Primary traumatic anterior shoulder dislocations are common and can have long-term personal implications for quality of life and the use of the arm for occupational activities and sport participation. A patient care pathway has been reported to contribute...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

Systemic inflammation is associated with increased cerebrospinal fluid CRP and may affect meningitis diagnostics

C-reactive protein (CRP) in cerebrospinal fluid (CSF) has been proposed as a highly specific diagnostic marker for bacterial meningitis. We investigated whether systemic inflammation, in the absence of CNS infection, can lead to detectable CSF CRP and examined the roles of plasma...

Multicentre performance and consistency of two deep learning models for malignancy probability estimation of incidental pulmonary nodules

Abstract Objectives A screening-trained deep learning (DL) model (DL1) for pulmonary nodule malignancy probability estimation on CT previously demonstrated good discrimination on a single-centre dataset of incidental nodules. An updated DL model (DL2) was trained on both screenin...

Direct composite injection molding with bilayered three-dimensional-printed clear index: a fully digital workflow case report of post-orthodontic anterior tooth wear

Background Recently, a new generation of high-strength flowable dental composites has been introduced by manufacturers.The manufacturers claim that these materials have enhanced mechanical and physical properties and are suitable for use in a wide range of direct anterior and pos...

Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility

Delirium is an acute neuropsychiatric syndrome with currently no effective treatment. The acute encephalopathy underlying delirium is characterized by diffuse oscillatory slowing on electroencephalography (EEG). Based on its capacity to modulate oscillatory activity, 10 Hz transc...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Bacteriophage inactivation to prevent carry-over in preclinical assays with mycobacteria

Abstract Background Bacteriophage carry-over, the continued lytic activity of residual phages after experimental sampling, poses a significant challenge in bacteriophage research, potentially skewing experimental results, particularly in the context of preclinical studies where p...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Identification of a Duplication in the RP17 Locus in an Individual With Pathogenic CEP290 Variants: Implications for RP17 Variant Classification

Purpose: To assess the pathogenicity of a novel duplication in the RP17 locus identified in a cone dystrophy proband with biallelic CEP290 variants. Structural variants (SVs) in this locus have previously been associated with dominant retinitis pigmentosa. Methods: Inheritance of...