Radboud University Medical Center

EXPRESS: Bayesian networks to estimate prognosis in vascular cognitive impairment and small vessel disease: integrated analyses of interdependent contributors to multiple outcomes

BACKGROUND: Vascular cognitive impairment (VCI) and small vessel disease (SVD) involve interconnected factors influencing multiple outcomes, also beyond cognitive decline. Bayesian networks (BNs) can help unravel these complex interrelations, which we demonstrate in this proof-of...

Implementing environmentally sustainable behavior in healthcare: an illustration of why behavioral definitions matter

Abstract Background Implementing more sustainable practices is crucial for reducing the environmental footprint of the healthcare sector. While organizational factors such as availability of sustainable materials are important, healthcare professionals’ adoption of sustainable be...

AXIAL: Attention-based eXplainability for Interpretable Alzheimer’s Localized diagnosis using 2D CNNs on 3D MRI brain scans

Deep learning models for Alzheimer’s disease (AD) diagnosis from magnetic resonance imaging (MRI) have achieved high performance, but clinical adoption remains limited because reliability and generalizability remain uncertain. Reported results are often difficult to compare becau...

Medication use during pregnancy in Europe and North America: a systematic review

To describe the mean number of medications used as well as the prevalence of medication use throughout pregnancy in Europe and North America, with a focus on use by trimester, type of medication, and use of harmful medications. A systematic review was performed searching MEDLINE,...

Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements

Abstract Introduction and Hypothesis Uterus preservation is increasingly used for uterovaginal prolapse (U-POP) repair despite ongoing concerns regarding future uterine, cervical, and adnexal pathology. We evaluated incidental pathology rates, associated risk factors, and created...

Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands

Abstract Purpose Post-haemorrhagic ventricular dilatation (PHVD) is a severe complication of germinal matrix–intraventricular haemorrhage in preterm infants and is associated with significant morbidity and adverse neurodevelopmental outcomes. In 2023, national recommendations for...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Weight management in cardiology practice: challenges and opportunities

Abstract Obesity poses a clear challenge to the cardiovascular landscape. In this viewpoint, we advocate that we need to prepare for the practical implementation of weight management in Dutch cardiology practice by 1) educating ourselves and our peers on obesity and its treatment...

Interferon-enhanced cytokine responsiveness in early trauma-induced immune dysfunction: a prospective observational pilot study

Severe trauma induces profound alterations in innate and adaptive immunity within hours after injury, which may contribute to increased susceptibility to secondary infections and adverse outcomes. While trauma-associated immune dysfunction has been extensively described, little i...

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

Extending women's health-span is a key challenge for the medical community. Although women live longer than men, they face a higher burden of chronic diseases, such as cardiovascular diseases (CVDs) and disabilities. Endogenous estrogens appear to benefit cardiovascular health, a...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

RCC-AID: Renal Cell Carcinoma AI Dataset for Medical Imaging Research

Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated datasets becomes inc...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

Dosing and delivery of bacteriophage therapy in a murine wound infection model

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage therapy remain underdeveloped. In a mouse wo...

The development and application of the integrative framework of feasibility and process of change of mindfulness-based interventions

Abstract A substantial number of qualitative studies have been conducted on feasibility and process of change of Mindfulness-Based Interventions (MBIs), but differences in terminology makes results of these studies difficult to compare. We conducted a targeted focused literature...

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Interplay between diaphragm thickening, force generation and lung volume change: a physiological study in health and diaphragm weakness

Introduction Diaphragm ultrasound is increasingly used to assess diaphragm function. Diaphragm thickening (DTF) is widely interpreted as a surrogate of diaphragm force generation. However, the independent contributions of force generation and lung volume change to diaphragm thick...

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa

Host-microbe interactions in the upper respiratory tract (URT) niches that form the first line of defense against respiratory infections are incompletely understood. We profiled immune and microbial features using minimally invasive samples from 44 healthy adults (20–65 years), i...

Navigation Bronchoscopy Specific Cone-Beam CT Software Enabling Pre- And Intraprocedural Guidance

BACKGROUND: Cone-beam computed tomography (CBCT)- guided bronchoscopy is an established technique for diagnosing peripheral pulmonary lesions, offering 3-dimensional imaging for both navigation and confirmation. However, its usability as a stand-alone modality is limited by a sub...