Queen Mary University of London

From six to twelve months: how extending the statutory prognostic threshold affected fast‑tracked end-of-life benefit access in England and Wales

Abstract Background To evaluate the impact of the 2022 change in prognostic eligibility criteria for the Special Rules for End of Life (SREL) pathway, from an expected death within 6 months to within 12 months, on the number and characteristics of awardees for fast-tracked financ...

Addressing youth mental health in Southeast Asia: a call to action with a spotlight on Malaysia

In Malaysia, 1 in 6 children aged 5–15 experience mental health difficulties, with this burden doubling between 2019 and 2023.1 Additionally, approximately 46% of youth report difficulties related to socialisation, including problems playing with others, making or maintaining fri...

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) rem...

The Nature of Turbulence at Subelectron Scales in the Solar Wind

Abstract The nature of turbulence at subelectron scales has remained an open question, central to understanding how electrons are heated in the solar wind. This is primarily because spacecraft measurements have been limited to magnetic field fluctuations alone. We resolve this by...

Electronic cigarettes for smoking cessation

RATIONALE: Electronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use for this purpose. This upd...

What works, for whom, and under what circumstances for recipients of training in opportunistic behaviour change conversations: A mixed methods realist evaluation protocol

Abstract Background ‘Making Every Contact Count’ (MECC) is a person-centred initiative that enables service providers across settings to support behaviour change through conversations about health and wellbeing. MECC has been widely implemented across the UK and internationally,...

A Modular Variable Stiffness Co‐Bot System Achieving Tasks Flexibility and Contact Compliance

ABSTRACT Enhancing contact compliance and task flexibility is essential for expanding the real‐world use of robotic systems. This paper presents a modular collaborative robot system that combines antagonistic actuation with hybrid soft–rigid variable‐stiffness components, includi...

Krylov complexity of supersymmetric SYK models

A bstract We study the effect of supersymmetry breaking on Krylov complexity in the $$ \mathcal{N}=2 $$ N = 2 SYK model under irrelevant and mass deformations of the Hamiltonian. The irrelevant deformation breaks $$ \mathcal{N}=2 $$ N = 2 supersymmetry down to $$ \mathcal{N}=1 $$...

Simple supercuspidal representations of $$\textrm{GSp}_4$$ and test vectors

Abstract We consider simple supercuspidal representations of $$\textrm{GSp}_4$$ GSp 4 over a p -adic field and show that they have conductor exponent 5. We study (paramodular) newvectors and minimal vectors in these representations, obtain formulas for their matrix coefficients,...

Programmable Anisotropic Terahertz Permittivity via High‐Aspect‐Ratio 3D‐Printed Dielectric Mesh Networks

ABSTRACT We present a 3D‐printed anisotropic dielectric with programmable terahertz permittivity. The design embeds a mesh network of high‐aspect‐ratio void channels within a bulk substrate. The anisotropic electromagnetic response, which depends on the orientation of the void ch...

Impact of sudanese chewing tobacco toombak on oral bacteria – a culture-based pilot study

Abstract Objective This study investigated the impact of the Sudanese smokeless tobacco Toombak on cultivable oral bacteria, its potential antibacterial properties, and its own microbial composition. Materials and methods Oral swabs from 20 adult male participants, including ten...

Metabolic plasticity supports a flexible nutritional symbiosis in Cardiocondyla ants

Abstract Nutritional symbioses have repeatedly evolved in insects, yet how hosts regulate these partnerships to balance benefits across development and environments remains unclear. Ants provide an exceptional system to address this question, as several lineages maintain ancient...

TSPO: a conserved mitochondrial conduit linking cellular homeostasis to disease

Abstract The translocator protein (TSPO) is an evolutionarily conserved 18 kDa protein localised to the outer mitochondrial membrane and increasingly recognised as a multifunctional regulator of cellular homeostasis. Although initially identified as the peripheral benzodiazepine...

Agentic AI: Vision and challenges

Agentic AI systems are increasingly viewed as a viable response to the shortcomings of static, rigid, and human-in-the-loop Artificial Intelligence (AI) systems. This is because autonomous operation enables rapid adaptation to dynamic, complex problems with improved time-critical...

Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study

Introduction: Prophylactic antimicrobial drugs are routinely administered for most surgical procedures worldwide. However, the benefit may be modest and supported by low-certainty evidence, while little is known about safety in contemporary practice.<br><br>Methods: O...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

A Machine Learning Platform for Imputing Missing Critical Quality Attributes in Pharmaceutical Development

Quality control is fundamental to drug development, with critical quality attributes (CQAs) serving as key indicators of product performance. However, missing or incomplete CQA data remains a persistent challenge throughout pharmaceutical research and manufacturing. In this study...

Machine learning of artistic fingerprints in jazz

Abstract Artists are often recognizable through collections of distinctive patterns (‘fingerprints’) in their work. Identifying such traits has important applications in authorship attribution, education, cultural heritage research and historical analysis. Here we focus on music,...

Into the Bermuda Triangle: How Prime Ministers Fall

ABSTRACT Eleven years after David Cameron promised ‘stability and strong government’; nine years after Theresa May pledged ‘strong and stable leadership’; and two years after Keir Starmer vowed to ‘stop the chaos’, the UK has its seventh prime minister in a decade. Most analyses...

Constraint satisfaction programming for the no-three-in-line problem

Using a constraint satisfaction formulation with rotational symmetry reduction, we exhibit configurations of 2 n points on the n × n grid for every 2 ≤ n ≤ 60 with no three collinear. These computations resolved every previously open case through n = 60 . We describe the formulat...