Queen Mary University of London

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Honeybee comb geometry emerges from local redistribution of angular space by worker construction activity

Abstract Honeybee comb is unique among animal architectures in its strikingly regular hexagonal cells, yet how this geometry emerges remains debated. Do bees construct perfect hexagons from the outset, or does regularity arise through later adjustments? We examined comb-building...

Process mapping: finding new routes to guideline adherence

Invited commentary of Shaw, L., Wilson, C., Haskell, L. et al. Process mapping to design theory-informed strategies reducing inappropriate HFNC use in emergency bronchiolitis care. Pediatr Res (2026). https://doi.org/10.1038/s41390-026-05304-w

Changing the world from Latin America: Milton Santos between transnational networking and multilingual worldings

On the occasion of the centenary of the birth of Brazilian radical geographer Milton Santos (1926–2001), we publish here for the first time the text of a guest lecture that he gave at the Fourth Meeting of Latin American Geographers (EGAL) in Mérida, Venezuela, in 1993. Unusually...

Interactions of land use and climate change disproportionately impact Lepidoptera of the five major insect orders

Abstract Land use and climate change are two major environmental pressures that interact to impact insect biodiversity. The wide ecological diversity, including life histories, among insects suggests that some groups will be more sensitive to these pressures than others, and it i...

The neurotypical listening subject in autistic young people’s accounts of participation in online affinity spaces

Abstract Autistic communicative practices are frequently judged as disengaged or inappropriate. Focusing on how such evaluations are described and contested by autistic users of online interest-based groups, this article theorises a neurotypical listening subject—an ideological l...

Early national comparison of robotic versus conventional hip replacements for arthritis using National Joint Registry data: target trial emulation study

Abstract Objectives To evaluate the early comparative effectiveness of robotic versus conventional total hip replacement (THR) in the UK. Design Target trial emulation study. Setting Public and private hospitals using data from the National Joint Registry of England, Wales, North...

Multivariate genetic analyses test for the presence of a general ‘ n ’ factor underlying neurodevelopmental conditions

Abstract Background Neurodevelopmental conditions often emerge early in life and have substantial genetic influences. There are significant genetic correlations between neurodevelopmental conditions, such as between autism spectrum disorder (Autism) and attention deficit‐hyperact...

Topological Dirac cluster synchronization on directed hypergraphs

Abstract Topological higher-order synchronization reveals collective phenomena demonstrating how topology shapes dynamics, yet providing a general theoretical framework for designing and controlling dynamical states on higher-order networks remains a challenge of the field. Here...

Recalibrating copyright liability for recommender platforms: Safe harbour, managed visibility, and tiered duties

This article asks how copyright liability should be recalibrated when short-video platforms do not merely host user uploads but manage their visibility through recommender systems. It argues that recommendation-amplified infringement exposes a structural mismatch between legacy s...

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity

Abstract Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune responses, particularly t...

Association Between Genetic Ancestry and Multiple Sclerosis Severity

OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...

The operation and abolition of ‘English Votes for English Laws’ in the UK parliament: differentiated voting rights and English ‘legislative consent’

In 2021 the UK House of Commons rescinded its short-lived ‘English Votes for English Laws’ (EVEL) procedures, which had delivered differentiated voting rights to MPs to compensate for asymmetric territorial governance arrangements. This article evaluates the operation and aboliti...

MHD-Driven natural convection and heat transfer enhancement in hybrid nanofluid-filled sinusoidal porous enclosure

Natural convection in nanofluids is an important process of thermal transport enhancement in the absence of external energy sources, and it makes it extremely preferred in terms of advanced thermal management. In the current research a detailed numerical research is conducted to...

TacVerse: A Multisensor Dataset and Benchmark for Cross‐Sensor Vision‐Based Tactile Perception

Vision‐based tactile sensors (VBTSs) enable robots to infer contact geometry and force‐related cues by imaging deformation through an internal camera, yet generalization across sensor designs remains poorly understood. We present TacVerse, a multisensor dataset and benchmark for...

Assessing dengue knowledge, attitudes and preventive practices in France and Italy: A cross-sectional study using participatory surveillance cohorts

The dengue virus, transmitted by Aedes mosquitoes, causes an estimated 100–390 million infections annually worldwide. With no treatment available, mitigation and prevention involve reducing mosquito breeding and limiting feeding opportunities. Due to changing climate conditions,...

Mechanism-Guided Combination Pharmacology of Curcumin and Methotrexate: Translational Strategies in Cancer and Emerging Applications in Rheumatoid Arthritis

Abstract Methotrexate (MTX) remains a cornerstone therapy in oncology and, to a lesser extent, rheumatoid arthritis (RA), yet its clinical utility in both settings is constrained by dose-limiting toxicities, interpatient pharmacokinetic variability, and the development of therape...

Wild Boar-Related Injuries in Wilderness Environments: Field-Oriented Management Principles and Evidence-Informed Clinical Recommendations

Wild boar-related trauma is uncommon but may result in severe injuries that pose diagnostic and therapeutic challenges, particularly in wilderness or resource-limited environments. Most scientific literature consists of isolated case reports, regional series, and forensic descrip...

Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial

Abstract The NHS-Galleri trial was a randomized controlled trial evaluating a multi-cancer early detection (MCED) test added to usual care. We reported elsewhere that the primary endpoint of a reduction in the incidence of stage III/IV cancer diagnoses in the intervention arm ver...

Adaptation of a maternal and child mHealth programme: an example from Aotearoa New Zealand

INTRODUCTION: Evidence for mHealth in the delivery of public health messages is growing. Cultural adaptations of existing mHealth programmes may be an efficient way to extend their reach to new target populations, but best practices for such adaptations are unclear. AIM: This pap...