Queen Mary University of London

Impact of high temperatures on healthcare utilisation among older adults: a scoping review

Abstract Background Rapid global ageing coincides with rising temperatures and increasing strain on healthcare services. High temperatures are associated with increased healthcare demand, yet evidence on older people’s healthcare utilisation remains fragmented and is often servic...

Dust Substructures and Line Perturbations driven by a Forming Planet in J16120

Abstract Hints of planet formation have been independently reported within the gap of the disc around 2MASS J16120668-301027 from millimetre continuum, infrared, and Hα observations. In this work, we present new evidence for ongoing planet formation based on Atacama Large Millime...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Effects of Sarpogrelate Hydrochloride in Combination with Aspirin on Blood Viscosity and Hemorheological Parameters in Patients with Peripheral and Coronary Artery Disease: A Randomized Controlled Trial

Background/Objectives: Hemorheological abnormalities, including increased blood viscosity and impaired red blood cell (RBC) deformability, contribute to poor vascular outcomes in patients with atherosclerotic diseases. Although sarpogrelate has shown vascular benefits, its additi...

Shifting and balancing under uncertainty: Ambidextrous leadership of digital strategies in the museums sector

The viability of museums and their past operating models have been undermined by external challenges including a paucity of funding, sectoral crises and the COVID-19 pandemic. Many have sought to implement digital strategies rapidly to support their survival, and some have strugg...

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a major therapeutic target in type 2 diabetes and obesity. Missense variation in GIPR could confer phenotypic effects through alterations to constitutive activity or functional responses to GIP or pharmacological...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Predicting psychiatric drug initiation after craniectomy: a retrospective cohort study

Psychiatric morbidity following craniectomy remains underexplored, with physical disability outcome measures forming the mainstay of follow-up tests used during rehabilitation. There are no predictive models to identify patients at a higher risk of new psychiatric drug initiation...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Psychological, social, and ethical implications of population-based genetic testing among adults: a systematic scoping review protocol with a focus on cancer

The standard clinical genetic testing model for hereditary cancers applies stringent eligibility criteria and consistently misses large numbers of at-risk cancer-susceptibility-gene (CSG) carriers in the general population, leading to missed opportunities for cancer screening/pre...

Development and validation of the personal recovery scale (ReConnect) for mental health in Ethiopia

Background: Socio-cultural context is crucial for conceptualising personal recovery in mental health, but existing measures are from Western, high-income countries. Aim: To develop and validate a mental health personal recovery measure for people with mental health conditions in...

The Causal Effect of Parents' Education on Children's Earnings

ABSTRACT We develop and estimate a model of endogenous schooling and earnings to isolate the causal effect of parents' education on children's outcomes. Identification uses earnings differences among children with equal schooling whose parents have different schooling. Health and...

Mapping the omics landscape for peri‐implant diseases: A scoping review

Abstract Objectives To map omics evidence across peri‐implant health, peri‐implant mucositis, and peri‐implantitis, and to identify recurring molecular patterns and candidate biomarker signals relevant to diagnosis, monitoring, and treatment. Materials and Methods This scoping re...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Flyby-induced high-eccentricity migration and the prevalence of hot Jupiters in M67

Abstract Few planetary systems form in isolation. Rather, interactions in their birth environments may sculpt their architectures or drive them into unstable configurations. Here we study the role of environmental perturbations in triggering dynamical instabilities leading to hot...

Squeezed‐State Semi‐Device‐Independent Quantum Randomness Generation

ABSTRACT This paper investigates semi‐device‐independent quantum randomness generation with a trusted binary pure‐state source and an untrusted binary detector whose side information is classical. We derive a closed‐form Shannon‐rate expression, depending only on the trusted Gram...

Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents

Abstract The co-existence of autism and attention deficit/hyperactivity disorder in tic disorders is a key factor influencing clinical decision-making. Given the shared clinical features and a potentially overlapping aetiology, the need to identify specific tic characteristics as...

Immune control of HIV viraemia in early paediatric infection is associated with induction of HIV-specific CD8+ T-cell activity following multiple treatment interruptions

BACKGROUND: Virus-specific CD8+ T-cells play an important part in HIV cure/remission in adults, yet their role in paediatric immune control is limited by tolerogenic early-life immunity. Very-early ART initiation, while effective in restricting viral reservoir size, also prevents...

Estimating the environmental impact of an HPC job – tools and challenges

Researchers and research funders are increasingly interested in understanding the environmental impacts of computational research, including impacts through both energy-intensive computations and the production and disposal of specialised computing hardware. However, these impact...

Inferential planning in the frontal cortex

Abstract How the brain plans and maintains sequences of future actions remains a central question in systems neuroscience. Recent studies in the frontal cortex have revealed that multiple elements of a sequence are represented simultaneously in separable neural subspaces, challen...