Peking University

CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis

Cancer-associated fibroblasts comprise diverse functionally distinct cellular subsets, with certain subpopulations exerting pivotal influence in shaping the pancreatic cancer immune microenvironment. Here we show that Lin28b+ cancer-associated fibroblasts contribute to establishi...

Temporal trends and age-period-cohort effects of tuberculosis incidence among older adults in western China, 2005–2020

Abstract Background Tuberculosis remains a major public health challenge in China, and older adults in western China bear a disproportionate burden. This study examined the temporal trends in TB incidence among older adults in western China and assessed the independent effects of...

Highly efficient dual-channel doublet emission in lanthanide cerium(III) complex

Abstract Dual-channel luminescent materials are attractive due to their unique electronic structures and potential applications in various fields. Different from traditional dual-channel emitters with closed-shell structure showing singlet fluorescence and/or triplet phosphoresce...

Evidence for heavy iron isotopic enrichment at Earth’s core-mantle boundary

Ocean island basalts exhibit heavier and more variable iron isotopic compositions (δ56Fe) than mid-ocean ridge basalts, but the origin of these signatures remains unresolved. Here we investigate whether Fe-rich ultralow-velocity zones at the core-mantle boundary can provide a dee...

A Tumor-Microenvironment-Responsive Chemically MaskedIL-2 Prodrug Potentiates PD-1 Checkpoint Blockade andElicits Robust Antitumor Efficacy

Abstract Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables...

A family of ultrathin non-van der waals kamiokite-type oxides for two-dimensional electronics

Non-van der Waals (vdW) two-dimensional (2D) metal oxides provide an opportunity to enrich the current 2D material library and accelerate the adoption of 2D materials into future electronic devices. However, the exploration of 2D non-vdW oxides remains limited, constrained by syn...

Axial N Disrupt d –π Conjugation of Asymmetric Fe─Cu Dual‐Atom Enhances CO 2 Electroreduction

ABSTRACT Precise spin‐polarization modulation of electronic structures in dual single‐atomic sites (DSAS) is critical yet challenging for boosting electrocatalytic CO 2 reduction reaction (CO 2 RR). Here, we report a Fe 3 d ‐orbital spin‐polarization regulation strategy through c...

Subliminal cues accompanied by action generate temporal expectancy and the role of supraliminal experience

Sensory events associated with motor actions are critical for perceptual calibration and motor control. Due to the stable temporal relationships between these events, individuals can anticipate the timing of one event based on another. While temporal expectancy is well-establishe...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

A biodegradable piezoelectric vertebral implant for programmable electro-neuromodulation in spinal cord injury

Spinal cord stimulation has emerged as a promising therapeutic strategy for spinal cord injury (SCI), yet conventional electronic implants remain limited by surgical risk and long-term safety concerns. We introduce a biodegradable piezoelectric cryogel (Piezo Gel) that enables pr...

A computational framework for Kármán gaiting in robotic fish: spatio-temporal perception and CPG-based reinforcement learning

Navigating in unsteady wake flows, such as Kármán vortex streets, presents a formidable challenge for biomimetic autonomous underwater vehicles. Biological fish achieve this by utilizing their lateral line sensory systems to perceive local flow gradients and adopting an energy-ef...

Durable Interphase Engineering on SiO x Anodes Through Interfacial‐Enrichment‐Facilitated Polymerization

ABSTRACT Constructing a robust solid electrolyte interphase (SEI) is a proven strategy to enhance the performance of Si‐based anodes by accommodating severe volume swings and suppressing interfacial side reactions. However, existing strategies that rely solely on either chemical...

Ferromagnetic Coupling in Dual‐Atom Nanozymes Enables Spin‐Favorable Catalase‐Like Catalysis for Rheumatoid Arthritis Therapy

ABSTRACT Iron dual‐atom (Fe DA) nanozymes, structurally analogous to natural catalase, exhibit promising catalase‐like (CAT‐like) activity, yet further improving their catalytic performance and elucidating the underlying mechanism remain major challenges. Herein, we developed a c...

Au Single‐Atom Interlayer Bridge Promotes Cross‐Layer Charge Transport and Intrinsic Catalytic Dual‐Sites Activation for Efficient CO 2 Photoreduction

ABSTRACT Layered photocatalysts are attractive for artificial photosynthesis, but their performance is often limited by inefficient charge transport across interlayer gaps and sluggish surface reaction kinetics. Herein, we propose a single‐atom interlayer bridge strategy by intro...

Qudit W and Greenberger–Horne–Zeilinger states on a two-photon chip

Abstract High-dimensional quantum entangled states exhibit unique properties. While generalizations like qudit Bell, Greenberger–Horne–Zeilinger (GHZ), and Cluster states have been studied, the qudit W states remain underexplored. We discover that a superposition of qudit Dicke s...

Clinical characteristics and influencing factors of roxadustat-induced central hypothyroidism in patients receiving peritoneal dialysis

Background This study aimed to investigate the clinical characteristics and risk factors of central hypothyroidism (CEH) in peritoneal dialysis (PD) patients treated with roxadustat. Methods This retrospective study enrolled maintenance PD patients followed up at Peking Universit...

Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction

Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study ai...

Immune profiling of chronic recurrent non-specific parotitis using CyTOF: a preliminary exploratory study

Chronic recurrent non-specific parotitis (CRNP) is characterized by recurrent parotid swelling and pain without identifiable obstructive lesions or systemic autoimmune diseases. The immunological features underlying CRNP remain poorly defined. Peripheral blood mononuclear cells (...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...