Peking University Third Hospital

Serial transthoracic echocardiography for hemodynamic monitoring and early warning of hypotension during elective cesarean delivery: a prospective observational study

Abstract BACKGROUND : Spinal anesthesia during cesarean delivery frequently causes maternal hypotension. Early detection of hemodynamic compromise before blood pressure decline could enable timely intervention. This study evaluates the use of serial transthoracic echocardiography...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

Ultrasound Features as Adjunctive Predictors of Pathological Grade in Phyllodes Tumors of the Breast: An Imaging‐Pathology Correlation Study

ABSTRACT Background and Aim Phyllodes tumors of the breast are rare fibroepithelial neoplasms whose pathological classification remains challenging due to marked histological heterogeneity, often complicating clinical management decisions. This study investigated whether preopera...

The Longitudinal Changes of Cervical Sagittal Alignment in a Non-surgical Cohort: A 12-Year Longitudinal Study

Study Design A retrospective longitudinal observational cohort study. Objective This study aimed to quantitatively evaluate the natural progression of cervical sagittal alignment parameters in non-surgical patients over a mean 12-year follow-up period, with a specific focus on ag...

Remimazolam vs. propofol sedation for video laryngoscopy in cervical spondylosis patients with suspected difficult laryngoscopy: a randomized controlled trial

Abstract Background This study aimed to explore the efficacy and safety of remimazolam vs. propofol for sedation during video laryngoscopy in cervical spondylosis patients with suspected difficult laryngoscopy. Methods In this single-center, prospective, randomized controlled stu...

Comparison of Birth Weight Outcomes Between Donor Sperm and Partner Sperm in Fresh Embryo Transfer Cycles: A Single‐Center Clinical Cohort Study

ABSTRACT Background Previous studies have found no significant difference in birth weight between donor sperm and partner sperm, and some studies have found that donor sperm is more likely to lead to small for gestational age (SGA). Objective Does the use of donor sperm affect th...

Longitudinal gut microbiome dynamics in neurosurgical ICU patients: Enterococcus expansion as a feature of microbial restructuring

Abstract Background Gut microbiota alterations are commonly observed in critical illness, but their temporal dynamics in neurosurgical ICU patients remain insufficiently characterized. This study aimed to describe postoperative microbial trajectories and their clinical context du...

Optimizing coronary CT angiography in patients with delayed contrast arrival using a free-breathing, high-threshold bolus-tracking protocol

OBJECTIVE: To investigate the performance of a free-breathing coronary computed tomography angiography (CCTA) protocol using a high-threshold bolus-tracking strategy in improving coronary enhancement and diagnostic visualization in patients with delayed contrast arrival. MATERIAL...

In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice

Abstract A systematic proteomic profile of oocytes from early-stage follicles, particularly primordial follicles, is critical to protect female reproductive capacity in the context of chemotherapy, yet progress has been hindered by the rarity of oocyte samples and technical chall...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Dental Erosion and Therapeutic Options

Tooth wear is a common, multifactorial non-carious dental hard tissue disease, and it may lead to a range of problems such as hypersensitivity, occlusal dysfunction, and aesthetic defects, significantly impacting patients’ oral health and quality of life. This article aims to sys...

Transthoracic echocardiography as a predictor of spinal anesthesia-induced hypotension in cesarean section: a prospective observational study

Spinal anesthesia-induced hypotension (SAIH) is a common complication during cesarean delivery and is closely associated with maternal intravascular volume status. However, reliable real-time assessment of volume changes remains challenging. This study aimed to evaluate whether t...

Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state

Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that promotes cardiomyocyte proliferation and hea...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Roxadustat and incidence of peritoneal dialysis-associated peritonitis: a propensity score–matched cohort study

BACKGROUND: Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), exerts pleiotropic effects beyond erythropoiesis, including modulation of inflammation and immune responses. Preliminary studies suggest Roxadustat may modulate inflammation to reduce perit...

Reliability and diagnostic performance of radiologic indices of the proximal humerus in evaluating bone mineral density: a retrospective study

Proximal humerus fractures (PHFs) are the third most common osteoporotic fractures. Assessment of bone mineral density (BMD) is clinically relevant in patients with PHFs. Several studies have proposed the use of radiologic indices, including the average cortical bone thickness (C...

Immune checkpoint inhibitor-associated acute interstitial nephritis: Pathogenesis and heterogeneity

Immune checkpoint inhibitor (ICI)-associated acute kidney injury is a significant complication of cancer immunotherapy, with acute interstitial nephritis (AIN) being the most common pathological type. This review systematically elaborates on the core pathogenesis, spectrum of pat...

A Tumor-Microenvironment-Responsive Chemically MaskedIL-2 Prodrug Potentiates PD-1 Checkpoint Blockade andElicits Robust Antitumor Efficacy

Abstract Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables...

Emerging Trends in the Incidence (1999–2022) and Mortality (1999–2023) of Thyroid Cancer in the United States: CDC WONDER Database Study

Background: Thyroid cancer (TC) is a common endocrine malignancy with a rising global incidence. This study examined trends in TC incidence and mortality in the United States over the past two decades. Methods: TC mortality data from 1999-2023 and incidence data from 1999-2022 we...

Machine learning-based fall risk prediction in community-dwelling older adults using dual-task spatiotemporal gait parameters

With global aging, falls have become a major threat to geriatric health. Traditional clinical assessments often suffer from a “ceiling effect,” failing to detect subtle motor impairments in high-functioning older adults. Moreover, steady-state gait analysis lacks ecological valid...