Okayama University

Whole exome sequencing and transcript analysis of a PTEN splice-site variant in a child with PTEN hamartoma tumor syndrome: a case report

Introduction PTEN hamartoma tumor syndrome (PHTS) is a hereditary tumor syndrome characterized by macrocephaly, neurodevelopmental disorders, mucocutaneous lesions, and predisposition to tumors. In childhood, the characteristic mucocutaneous and tumor-related manifestations may n...

A descriptive histopathological framework for radiotherapy-related muscle injury in salvage surgery for hypopharyngeal cancer

BACKGROUND: Radiotherapy-related normal tissue injury is clinically important in salvage surgery for hypopharyngeal cancer, but its histopathological features in clinical specimens remain poorly defined. AIMS/OBJECTIVES: To propose a practical descriptive histopathological framew...

Positive selection of IgG over IgM plasma cells through BCR isotype–specific antigen presentation and signaling

During a primary immune response, B cells can undergo isotype switching from an immunoglobulin M (IgM) B cell receptor (BCR) to an IgG BCR. B cells that have switched to IgG give rise to more bone marrow long-lived plasma cells (PCs) compared with those expressing IgM, but how BC...

Effect of operator experience level on clinical outcomes of indirect- and direct-bonding techniques: A single-center, open-label, quasi-randomized controlled clinical trial

Objective: This study aimed to compare the clinical outcomes of indirect- and direct-bonding techniques for bracket placement in orthodontic treatment, focusing on the influence of operator experience. Methods: A total of 153 patients were quasi-randomly assigned to the indirect-...

MIBO Core Protocol Package v2.0

MIBO Core Protocol Package v2.0 prospectively defines a fully automated, provider-API observation design for MIBO Core. The primary API Core Interface (ACI) condition follows the four registered MIBO service lineages with the unchanged 24 Japanese/English Query Forms and ten inde...

Granular Swollen Epithelial Cells in Native Kidney Biopsies: Prevalence, Clinicopathological Associations and Kidney Outcomes

Background/Objectives: Granular swollen epithelial cells (GSECs) have been described primarily in mitochondrial cytopathies, in which they are regarded as a characteristic pathological finding that may aid in the diagnosis of mitochondrial dysfunction; however, their prevalence a...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

The Antioxidant Activity of α-Tocopherol Metabolites in Comparison with the Parent Compound in Hepatocytes

α-Tocopherol (αT) is the major form of vitamin E. Although it is metabolized in the liver when high levels of αT are present, the function of its metabolites has not yet been fully elucidated. This study aimed to evaluate the antioxidant activities of the αT metabolites, α-carbox...

Rheological properties of clay-containing Martian regolith simulant slurries

The rheological properties of slurries prepared from two Martian regolith simulants with different smectite contents, JEZ-1 and MGS-1C, were investigated in the context of in situ resource utilization (ISRU). Flow curve measurements revealed that both slurries exhibit yield-stres...

Photo-triggered construction of nitrogen-containing aromatic heterocycles under physiological conditions

Abstract Precise spatiotemporal control of molecular function is essential for probing biological systems and developing safer therapeutics. Herein, we review photoinducible intramolecular cyclization reactions developed in-house for generating nitrogen-containing aromatic hetero...

MIBO-Education Protocol Package v1.0

MIBO-Education Protocol Package v1.0 provides the frozen scientific specification for MIBO-Education, a longitudinal observatory of educational behavior in general-purpose generative-AI services and an official Satellite of the Machine Information Behavioral Observatory (MIBO). T...

MIBO-Education Protocol Package v1.0

MIBO-Education Protocol Package v1.0 provides the frozen scientific specification for MIBO-Education, a longitudinal observatory of educational behavior in general-purpose generative-AI services and an official Satellite of the Machine Information Behavioral Observatory (MIBO). T...

Frequency-specific structure-function decoupling underlies core symptoms in schizophrenia

A major challenge in schizophrenia is its clinical heterogeneity, which has obstructed biomarker identification. Recent research indicates that frequency-specific structural eigenmodes, which govern distinct spatiotemporal propagation patterns, are linked to the functions of unim...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

MIBO Core Protocol Package v1.0

MIBO Core Protocol Package v1.0 provides the version-controlled methodological specification for MIBO Core, a sentinel panel survey of public generative-AI information behavior. The package defines persistent public service-lineage panel units, a fixed bilingual query instrument,...

Accuracy and risk factors for poor cup orientation in total hip arthroplasty: a comparison between supine and lateral registration using a portable navigation system

INTRODUCTION: Accurate acetabular cup orientation is essential in total hip arthroplasty (THA). Portable inertial navigation may improve reproducibility, but accuracy in lateral decubitus THA may depend on the pelvic registration workflow. We compared cup placement accuracy betwe...

Comparison of sulfate and other anionic functional groups in cellulose pulp sheet functionality

Sulfated cellulose pulp (SCP), phosphorylated cellulose pulp, and 2,2,6,6-tetramethylpiperidine 1-oxyl radical-oxidized cellulose pulp are cellulose derivatives with distinct functional groups introduced through controlled chemical modifications. SCP has been reported to be synth...

Arsenic removal from wastewater using the bio-based graphene oxide and magnetite nanocomposites: reaction kinetic study

Water contamination with arsenic (As) is a global issue challenging the environment, ecosystem, and human health. Among arsenic decontamination techniques, sorption is highly acknowledged, efficienct, low cost and simple technique and gaining much interest in recent decades. Effi...

Algorithm for classifying the underlying pathologies in postpartum hemorrhage using bleeding rate, fibrinogen, and fibrin/fibrinogen degradation products: a case series study

Abstract Background Understanding patients’ underlying pathologies is essential for appropriate treatment during postpartum hemorrhage (PPH) management. The objective of this study is to develop an algorithm that quantitatively classifies the underlying pathologies in PPH using c...