Okayama University

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Carbon solubility and liquid–liquid immiscibility in Fe–C–S ternary system up to 6 GPa: implications for the core of small planetary bodies

Abstract High-pressure, high-temperature experiments were conducted in a multi-anvil press using seven different starting compositions to investigate the phase relations of Fe–C–S liquids at pressures up to 6 GPa and temperatures up to 2000 K. Quenched samples revealed immiscible...

A first case report of recurrent gastric cancer harboring a BRAFV600E mutation responding to dabrafenib plus trametinib

Abstract Comprehensive genomic profiling (CGP) has been increasingly implemented in clinical practice; however, only a limited proportion of patients ultimately receive genomically matched therapies. The BRAF V600E mutation is extremely rare in gastric cancer, and effective targe...

Macroscopic and microscopic visualization of Pseudomonas syringae pv. tabaci infection using complementary bioluminescent and fluorescent reporter systems

Abstract The development of bioluminescent and fluorescent reporter systems has enabled visualization of plant-pathogenic bacterial infection dynamics, providing insights into detailed mechanisms of infection and potential applications for disease control. Pseudomonas syringae pv...

Tumor-to-tumor metastasis of small cell carcinoma of presumed pulmonary origin to a sphenoid ridge meningioma: A diagnostic pitfall in preoperative systemic evaluation

Background: Tumor-to-tumor metastasis (TTM) to a meningioma is rare. Atypical meningioma-like lesion with systemic cancer risk factors warrants evaluation for metastatic disease before resection. Case Description: An 80-year-old man with a smoking history and pulmonary emphysema...

Real‐World Achievement of Guideline‐Concordant Treatment and Survival in Osteosarcoma: A Nationwide Registry Study

ABSTRACT Real‐world achievement of guideline‐concordant treatment in osteosarcoma remains unclear. This study aimed to determine stage‐specific rates of guideline‐concordant treatment, evaluate their association with survival outcomes, and identify factors associated with non‐con...

Modulation of Open-Shell Character in Dibenzoazaborine Dications through Amino-Substituent Modification

Abstract Oxidation of dibutylamino-substituted dibenzoazaborine Bu2NDBAB afforded the air-stable dication [Bu2NDBAB](SbF6)2 in 83% yield, with an NIR absorption band at 943 nm. Structural analysis revealed pronounced oxidation-induced quinoidal distortion. Unlike the previously r...

Acute acquired comitant esotropia in the smartphone era: a narrative review

Abstract Purpose Acute acquired comitant esotropia (AACE) has received increasing attention in the smartphone era, following numerous clinical reports suggesting an association with intensive and prolonged device use. However, it remains unclear whether smartphone use is a direct...

Rapid fluvial response to meter-scale coseismic coastal uplift during the 2024 Noto Peninsula earthquake

Abstract The response of river profiles to relative base-level change is a key topic in earth surface processes, but observations capturing these changes on unconsolidated deposits at a 1–10 years timescales are scarce. We monitored geomorphic changes at the Hakka River mouth aft...

Intraoperative hypotension and postoperative acute kidney injury in patients undergoing prolonged intra-abdominal surgery: a retrospective, observational study

Abstract Background Intraoperative hypotension may be associated with postoperative acute kidney injury (AKI). However, patients undergoing prolonged intra-abdominal surgery may be susceptible to postoperative AKI due to procedure-related physiological changes. Therefore, this st...

An Enhanced Generative AI-Based Assistant for IoT Application System Deployment on SEMAR Platform

Nowadays, IoT application systems are increasing in importance for improving efficiency, safety, and quality of operations, services, and products in various sectors of factories, shops, offices, and farms. However, the hurdle in deploying a new system is high for many possible u...

Elucidating the true catalytic nature of first-row transition metal coordination compounds under oxygen-evolution conditions

The oxygen-evolution reaction (OER) is the kinetic bottleneck of electrochemical water splitting and, therefore, a central challenge in the development of sustainable hydrogen production technologies. First-row transition metal coordination compounds have attracted considerable a...

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical outcomes. Although PDAC has traditionally been thought to arise from ductal epithelial cells, recent studies using genetically engineer...

Zero-field NMR for the Antiferromagnetic Phase of α -Mn at Ambient Pressure

We performed detailed zero-field nuclear magnetic resonance measurements of α-Mn at ambient pressure to clarify its antiferromagnetic phase evolution. The 55 Mn internal magnetic field at site III vanishes continuously as the Néel temperature T N1 = 95 K is approached, which is c...

Two postnatal mouse models with Pth1r deletion reproduce limb phenotype for Blomstrand chondrodysplasia

Blomstrand chondrodysplasia (BOCD) is a lethal autosomal recessive disorder characterized by skeletal and facial deformity and caused by loss-of-function variants in the parathyroid hormone 1 receptor gene ( PTH1R ). Because BOCD results in embryonic lethality in humans, animal m...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry

This study evaluated the clinical and demographic characteristics of biopsy-proven rapidly progressive glomerulonephritis (RPGN), with histological evidence of renal vasculitis. We focused on five vasculitis-related nephritides: MPO-ANCA, PR3-ANCA, anti-GBM, IgA vasculitis (IgAV)...

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...

Interactions of Water Molecules Adsorbed on Hydrophilic Substrates Clarified by Transport Characteristics of Graphene

Abstract Hydrophobic treatment of SiO2/Si substrates is indispensable for achieving excellent transport characteristics in graphene devices. Although the interaction of the carriers with electric dipole moments of water molecules is believed to degrade the transport characteristi...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...