Oakland University

Nipsnap 1 deficiency shifts neuronal and synaptic signaling toward inflammatory pathway and impairs cognitive functions in the aging brain

Mitochondrial quality control is essential for maintaining neuronal function during aging. Nipsnap1 (Nip1), a mitochondrial protein involved in mitophagy, metabolic regulation, and cellular senescence, has emerged as a potential regulator of tissue homeostasis; however, its role...

A Cycle of Gendered Vulnerability: Understanding Violence, Poverty, and Systemic Failure Among Refugee Women in Malawi

Gender-based violence (GBV) is an urgent global health and social problem. GBV has implications for women's health outcomes and causes disruption to an individual's ecosystem, including their educational attainment, economic stability, and safety. Refugee women are an underserved...

A Mathematical Model for Chemotherapy, Immunotherapy and Virotherapy Treatments of Cancer

We extend the model for cancer treatment by adding the modality of virotherapy in addition to chemotherapy and immunotherapy. This dynamical system models three different ways to fight the spread of solid cancer, such as melanoma, glioblastoma, head and neck cancers, and pancreat...

The Oriented Chromatic Number of Random Graphs of Bounded Degree

ABSTRACT The chromatic number of the random graph has long been studied and has inspired several landmark results. In the case where , Achlioptas and Naor showed the chromatic number is asymptotically two‐point concentrated. Kemkes et al. later proved that the same result holds f...

An Exploration of Domestic Violence and Factors Influencing Help-Seeking and Coping Mechanisms Among Hmong American Women

This study examines the help-seeking and coping experiences of 12 Hmong American women survivors of domestic violence, ages 43 to 60. Thematic analysis identified two main themes: sociocultural determinants of help-seeking and finding strength and growth during and in the afterma...

Is Wastewater Surveillance Predictive during the Endemic Phase of Respiratory Disease? An Analysis Based on Clinical, Wastewater, and Digital Search Data in Detroit, Michigan

Abstract Wastewater-based epidemiology (WBE) has emerged as a major public health innovation catalyzed by the COVID-19 pandemic. However, its potential remains underexplored during and after COVID-19’s transition to endemicity. This study evaluates WBE’s potential to identify the...

Global burden of moyamoya syndrome in pediatric sickle cell disease and implications for the neurosurgical workforce: a systematic review

Abstract Objective The aims of the study were twofold: 1) quantify the global burden of pSCD|MMS, and 2) estimate the number of children who warrant specialist evaluation for possible surgical revascularization. Methods A systematic review was conducted following PRISMA guideline...

Nursing Students’ Knowledge of Provider-Committed Murder of Patients: A Before and After Study

BACKGROUND: Patient safety is a central goal of health care systems, and preventing harm to patients, including patient murder, is a critical safety priority. AIM: To evaluate undergraduate students' knowledge of murder of patients by health care providers, a before and after stu...

Ultra-fast spin Hall nano-oscillator based microwave spectral analysis

Abstract Ultra-fast spectrum analysis based on rapidly tuned spintronic nano-oscillators has been under development for the last few years and has already demonstrated promising results. Here, we demonstrate an ultra-fast microwave spectrum analyzer based on a chain of five mutua...

Long-Term Prosthesis Survival After Total Hip Arthroplasty in Young Women with Developmental Dysplasia of the Hip: A Narrative Review of Instability, Revision Risk, and Reproductive Health Considerations

Background/Objectives: Total hip arthroplasty (THA) reliably improves pain and function, but implant longevity in women aged ≤50 years is influenced by longer duration of implant use and distinct failure mechanisms. Developmental dysplasia of the hip (DDH) is a common underlying...

“I Will Never Be Enough Because My Skin Color Isn’t Right”: Structural Racism and Healthcare Access Following Nonfatal Strangulation Among Black Women Survivors of Intimate Partner Violence

Background: Nonfatal strangulation (NFS) is one of the most lethal forms of intimate partner violence (IPV) that is associated with increased risk of future homicide, yet it frequently goes unrecognized within healthcare settings. Black women experience disproportionately high ra...

Microbiome-Based Therapeutics in Oncology: Expanding Indications Beyond C. difficile

The intestinal microbiome has emerged as a clinically significant modulator of outcomes across multiple domains of cancer care. In hematopoietic stem cell transplantation (HSCT), loss of microbial diversity and depletion of short-chain fatty acid-producing commensals are independ...

Promoting Stress-Related Growth Among Historically Marginalized Communities: A Trauma-Informed Framework in Response to Political Stress

Abstract Individuals who hold historically marginalized identities (e.g., undocumented communities, LGBTQ+ people, Asian Americans) may experience higher levels of psychological distress, relational strain, traumatic stress, and physiological symptoms from a shifting sociopolitic...

Catalyst-Free Urea Synthesis from Methanol and Nitrogen via Radical-Mediated Redox Coupling on Aqueous Microdroplets

Abstract Urea is an indispensable nitrogen fertilizer and an important feedstock for chemical synthesis. Compared to the energy-intensive Bosch–Meiser process, photocatalytic redox coupling offers a sustainable approach toward urea synthesis. However, artificial photosynthesis re...

With Grief and Growth: Examining Volunteer Motivations and Their Relationships to Grief Intensity and Posttraumatic Growth

Engaging in volunteer work could be associated with posttraumatic growth (PTG). Investigating the associations among motivations to volunteer, PTG, and grief can help us understand how people cope with death. Volunteer functions theory posits six functions of volunteer motivation...

Intimate partner violence against Jordanian women: a systematic review of prevalence, associated factors, and health outcomes

Intimate partner violence (IPV) is a pervasive public health problem in many countries, including Jordan. To our knowledge, no systematic reviews have been conducted in Jordan regarding the prevalence of IPV, its associated factors, and related health outcomes. This systematic re...

Differentially Private Hierarchical Spectral Clustering

We study hierarchical spectral graph clustering under edge differential privacy (DP) through the lens of iterative eigenvector estimation on adjacency matrices. We propose a differentially private recursive spectral framework, where each binary partition is obtained via a rank-on...

SIR Model with Dependent Infectivity and Death Rates

This work constructs, analyzes and simulates a new general SIR epidemiological model for the spread of a generic long-time disease, in which the coefficients of infectivity and death rate are system variables. Diseases, such as COVID-19, have demonstrated clearly that infectivity...

Molecular methods for differentiating Phragmites australis subspecies and identification of hybrid stands in the Upper Midwestern United States

Abstract Premise In North America, Phragmites australis (common reed) has drawn a great deal of research attention. Non‐native P. australis subsp. australis is a noxious weed that has locally displaced native P. australis subsp. americanus in some areas. Although morphological fe...

Multi-Backbone U-Net segmentation and interpretable hybrid deep learning classification for lung cancer detection in chest CT images

Lung cancer remains the leading cause of cancer-related mortality worldwide, and its early and accurate diagnosis from chest CT imaging is complicated by overlapping radiological features between benign and malignant lesions, as well as by the limited cross-institution validation...