Nantes Université

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Beta Atlas: Charting Global Production of Nonconventional β − -Emitters for Targeted Radiopharmaceutical Therapy—Part 1

β-minus particle (β−)–emitting radionuclides have long been central to targeted radiopharmaceutical therapy. Interest in expanding their repertoire beyond conventional options has grown over time, as the need for radionuclides with different emission profiles and theranostic pote...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Synthesis, Photophysical Properties, and Ab Initio Calculations of 2-(2-Hydroxy/methoxyphenyl)pyrimidines Substituted by Sterically Hindered Electron-Donating Groups

Abstract A series of 2-(2-hydroxyphenyl)pyrimidines bearing sterically hindered electron-donating groups (DMAC, PXZ, PTZ, and NPh2), together with their methoxy precursors, were synthesized and investigated by photophysical studies and ab initio calculations. While the hydroxy de...

Daratumumab in Combination With High‐Dose Cytarabine and Amsacrine as an Effective Salvage Therapy and Bridge to Allogeneic Hematopoietic Stem Cell Transplantation for Refractory T‐Cell Acute Lymphoblastic Leukemia: A Case Report

ABSTRACT Patients with refractory or relapsed T‐cell acute lymphoblastic leukemia (R/R T‐ALL) have dismal outcomes. While immunotherapies are growing opportunities for B‐cell ALL, targeted therapies for T‐ALL remain limited. The CD38 antigen, steadily expressed on T‐ALL blasts, r...

Unravelling the impact of nitrogen deprivation on the morphology and nanomechanical properties of Parachlorella kessleri

Abstract Nitrogen deprivation is commonly applied to enhance lipid accumulation in microalgae for third-generation biofuel production. However, its influence on cell wall morphology and nanomechanical properties, which critically affect downstream processing, remains poorly explo...

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

ABSTRACT The prevalence of antimicrobial resistance (AMR) within the common bacterial pathogen Streptococcus pneumoniae makes it a priority for the development of new antibiotics. While artificial intelligence (AI) has recently boosted phenotype‐based repurposing of drugs for oth...

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Probabilistic inference of homonymous and heteronymous recurrent inhibition in human muscles from large-scale motor neuron recordings

Understanding how spinal circuits shape motor neuron behavior during muscle contractions remains a major challenge. Here, we combined large-scale motor unit recordings with simulation-based inference to generate probabilistic estimates of homonymous and heteronymous recurrent inh...

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

ABSTRACT Understanding how microbial populations generate and modulate electrical signals remains a major technical challenge because extracellular ionic processes are inherently weak, spatially distributed and stochastic. Here, we introduce a mesoporous ultra‐low‐impedance PEDOT...

Combined prognostic value of age at onset and socioeconomic status for long-term survival in metastatic breast cancer

We investigated the combined long-term prognostic value of age at onset and socioeconomic status (SES) on breast cancer overall survival (OS) and metastasis-free survival (MFS) in a cohort of women with metastatic breast cancer. Age at onset was defined as the age at primary diag...

Describing the emotional change experienced by patients with chronic somatic diseases who took part in a supportive program with complementary therapies: a qualitative study

Quantitative studies have suggested that complementary therapies (including mind-body and art therapies) are relevant to support patients with chronic somatic diseases. The “Health Promotion Education” department of Nantes University Hospital created in 2012 an association entitl...

Semiclassical tunneling for some 1D Schrödinger operators with complex-valued potentials

We consider the non-selfadjoint, semiclassical Schrödinger operator \mathscr{L}(h) := -h^{2}\partial_{x}^{2}+e^{i\alpha}V , where \alpha \in (-\pi,\pi) and V\colon \R\to \R_{+} is even and vanishes at exactly two (symmetric) non-degenerate minima. We establish a semiclassical tun...

Oozing characteristics in screw extrusion additive manufacturing

Abstract Additive Manufacturing (AM) is a non-conventional manufacturing process that enables the physical realization of components through layer-by-layer material deposition. Among the different AM techniques, Screw Extrusion Additive Manufacturing (SEAM) uses an extruder screw...

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Protein Binding Determination of Cefepime, Flucloxacillin, Meropenem, Piperacillin and Tazobactam by Ultrafiltration in Critically Ill Patients: The Choice of Device Matters

Therapeutic drug monitoring (TDM) and pharmacokinetic studies of beta-lactam antibiotics in critically ill patients aim to define optimal dosing and require accurate measurement of unbound drug concentrations. This study compared the performance of two ultrafiltration devices, Ce...

Transmission Eigenvalue-Free Regions Near the Real Axis in the Case of Strong Damping

We consider interior transmission problems with one complex-valued refraction index independent of the spectral parameter, that is, with a strong damping term, and we suppose that it does not vanish on the boundary. Under some quite general conditions, we obtain transmission eige...

Structural Responses of Aluminoborosilicate Glasses to Pressure and Iodine Incorporation: An Advanced NMR Investigation

ABSTRACT Iodine‐129 is a critical challenge for nuclear waste immobilization due to its high mobility and extremely long half‐life (1.57 × 10 7 years). Although high‐pressure glass synthesis has been shown to significantly enhance iodine solubility, the structural mechanisms gove...

Post launch spectral and radiometric performances of MAJIS, the VIS-NIR imaging spectrometer of JUICE

Abstract. The post-launch spectral and radiometric performances of MAJIS, the VISNIR imaging spectrometer of the ESA Jupiter Icy Moon Explorer (JUICE), have been evaluated using observations performed during the Lunar-Earth Gravitational Assist (LEGA) of 19–20 August 2024 and obs...

Tunable asymmetric swimming in biflagellate microswimmers

Many biological microswimmers can modulate their swimming gait to achieve directional control of motility, especially when performing steering towards specific directional cues. This can be achieved without the need for obvious morphological or structural asymmetries in the form...