Memorial Ankara Hospital

Radiographic Changes in Patellar Height Following Rapid Weight Loss After Sleeve Gastrectomy: A Retrospective Observational Study

Background/Objectives: Rapid weight loss following sleeve gastrectomy substantially reduces mechanical loading across the lower extremities, yet its effects on patellar height remain unknown. This study investigated early postoperative radiographic changes in patellar height foll...

Maternal Serum Isthmin-1 as a Novel Biomarker for Late-Onset Fetal Growth Restriction

Background/Objectives: To investigate maternal serum Isthmin-1 (ISM1) levels in pregnancies complicated by fetal growth restriction (FGR) and to evaluate its potential discriminatory performance for FGR. Methods: This prospective cross-sectional study included 44 pregnant women w...

Association between PhenoAge-assessed biological age and survival outcomes in solid tumor patients treated with immune checkpoint inhibitors

Abstract Background Chronological age may influence immune function, but individuals of the same age may differ in biological aging. We evaluated the association between biological age and clinical outcomes in patients with solid tumors treated with immune checkpoint inhibitor mo...

Meteorological factors and daily afebrile seizure counts in children: a time-series analysis

Abstract Background The relationship between meteorological factors and seizure occurrence remains controversial, particularly in pediatric populations where data are limited and may be confounded by febrile seizures. This study aimed to investigate the association between daily...

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion–induced pressure ulcer model, a pilot exploratory animal study

Objectives: This study aimed to determine the messenger ribonucleic acid (mRNA) expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-17, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) -5 in an acute ischemia/reperfusion (I/R)-induced pressure ulc...

Outcomes of Iliac Crest Bone-Block Arthrodesis After Failed First MTP Joint Surgery With Bone Loss

Background: Failed first metatarsophalangeal (MTP) joint surgery with bone loss is a challenging revision problem. This study aimed to evaluate the radiographic and clinical outcomes of iliac crest bone-block arthrodesis in this setting. Methods: This retrospective cohort include...

Etelcalcetide Versus Cinacalcet for Secondary Hyperparathyroidism in Hemodialysis Patients: A Multicentre Comparison with 24 Months of Follow-Up

Background/Objectives: Secondary hyperparathyroidism (SHPT) is a prevalent complication of end-stage kidney disease. Although etelcalcetide has demonstrated short-term superiority over cinacalcet in randomized trials, real-world comparative data beyond 12 months remain scarce. Th...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

The effect of pulmonary nodule presence on disease severity and course in ANCA-associated vasculitis: a multicenter cohort study

Pulmonary nodules are common in ANCA-associated vasculitis (AAV), but their clinical relevance remains unclear. This study assessed the influence of pulmonary nodules and radiological features on clinical characteristics and outcomes in AAV. In this multicenter retrospective coho...

Post-Recurrence Outcomes Associated with a Bevacizumab-Containing First-Recurrence Strategy in Glioblastoma: A Propensity-Weighted Single-Center Cohort Study with Competing-Risk Analysis

Background/Objectives: Bevacizumab is widely used at recurrence in glioblastoma, but comparisons are complicated by multimodal treatment selection and progression assessment. We examined outcomes associated with a bevacizumab-containing first-recurrence strategy and explored the...

Early electrophysiological differentiation of faces and face-like stimuli in pediatric traumatic brain injury

Pediatric traumatic brain injury (PTBI) may disrupt neurodevelopmental systems supporting social perception, including the rapid processing of facial information. Although face perception is essential for social interaction, little is known about how children with TBI process amb...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Subclinical Cardiac Dysfunction in Children with Iron Deficiency Anemia Assessed by Tissue Doppler and Speckle-Tracking Echocardiography

OBJECTIVE: Iron deficiency is the leading cause of anemia in childhood and may induce cardiovascular adaptations, including increased heart rate, elevated cardiac output, plasma volume expansion, and myocardial remodeling. Beyond hematologic consequences, reduced iron availabilit...

How reliable is percutaneous transforaminal endoscopic discectomy during the learning curve? A comparison of outcomes with microsurgical discectomy experiences

We aimed to share our early experience with percutaneous transforaminal endoscopic discectomy (PTED) during the initial phase of the learning curve and to compare its clinical and perioperative outcomes with microsurgical discectomy (MD) in selected patients with symptomatic lumb...

Multidimensional Associations Between Psychiatric Symptoms, Sleep Disturbance, Biological Variables, and Fibromyalgia Severity: A Classification and Regression Tree and Path Analysis Study

Background: Fibromyalgia (FM) is a complex chronic pain disorder characterized by interactions among psychological, biological, and clinical factors. Although psychiatric symptoms and sleep disturbance are recognized contributors to disease burden, their multidimensional relation...

Reduced Vagal Compound Action Potential Amplitude Is Associated with Glomerular Injury in an Experimental Rabbit Model of Severe Subarachnoid Hemorrhage

Background: Subarachnoid hemorrhage (SAH) induces a sympathetic surge and systemic inflammation that may impair renal perfusion and glomerular integrity. Although the vagus nerve is central to autonomic and anti-inflammatory regulation, its relationship to renal structural injury...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

Primary ACL Repair and Reconstruction in Isolated ACL Ruptures: Forgotten Joint Scores and the Association Between Residual Laxity and Joint Awareness

Background: Primary anterior cruciate ligament (ACL) repair has recently reemerged as a treatment option for carefully selected proximal ACL tears. However, evidence regarding patient-reported joint awareness and the relationship between postoperative laxity and joint awareness r...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Eating disorder–related attitudes as predictors of pre-frailty/frailty in older adults: a cross-sectional clinical study

Frailty is a prevalent geriatric syndrome influenced by nutritional status, body composition, and functional capacity. Nevertheless, the role of eating disorder–related attitudes and behaviors in older adults is not definitively known. Therefore, this study was conducted to inves...