Memorial Ankara Hospital

Prognostic Value of Serial Alkaline Phosphatase-to-Albumin Ratio for Mortality After Transjugular Intrahepatic Portosystemic Shunt

Background: Prognostic assessment after transjugular intrahepatic portosystemic shunt (TIPS) remains challenging, and currently available scores are based mainly on pre-procedural variables. The alkaline phosphatase-to-albumin ratio (APAR) is a simple laboratory-derived marker th...

Association of Platelet–Albumin–Bilirubin and Albumin–Bilirubin Scores with Angiographic No-Reflow in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI

Background: The platelet–albumin–bilirubin (PALBI) and albumin–bilirubin (ALBI) scores integrate routinely available laboratory parameters with potential relevance to microvascular injury. We investigated their associations with angiographic no-reflow and incremental predictive v...

Factors Predicting Non-diagnostic Results in Ultrasound-Guided Percutaneous Pancreatic Biopsy

The present study aimed to evaluate the diagnostic adequacy and safety profile of ultrasound-guided percutaneous pancreatic biopsy and to determine predictors of non-diagnostic results. In this retrospective single-center study, consecutive patients who underwent ultrasound-guide...

Neonatal Niemann–Pick type C: a case series integrating clinical findings, structural modeling and ACMG-based variant interpretation

Abstract Background Niemann–Pick disease type C (NPC) is a rare autosomal recessive lysosomal storage disorder that can present in the neonatal period with cholestasis and hepatosplenomegaly, making early diagnosis challenging. We report a case series of three neonates evaluated...

Phenotype–genotype relationship and evaluation of disease severity in pediatric patients diagnosed with Familial Mediterranean Fever

Aims:Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in theMEFVgene and characterized by recurrent inflammatory attacks. The present study aimed to evaluate the relationship between clinical findings,MEFVmutation distribution, and di...

Clinical, biochemical and genetic spectra of carnosinemia: a systematic review of case reports and case series

Abstract Carnosinemia, also referred to as carnosinase 1 (CNDP1) deficiency, is an ultra-rare inborn error of metabolism characterized by impaired CNDP1 activity and carnosine degradation. The clinical significance and phenotypic spectrum of this condition remain poorly defined,...

Clinical management, antifungal susceptibility, and predictors of 28-day mortality in Candidozyma auris candidemia: a single-center cohort study

Candidozyma auris (Candida auris) candidemia is a serious healthcare-associated infection with substantial mortality and limited treatment options. We retrospectively evaluated adult patients with C. auris candidemia at a tertiary care center between June 2022 and December 2025 t...

European epidemiology of kidney cancer

ABSTRACT Kidney cancer represents a substantial and heterogeneous health burden across Europe. Using contemporary GLOBOCAN 2024 estimates, we provide a granular assessment of kidney cancer epidemiology across European countries, integrating geographical, sex- and age-specific, te...

Effectiveness of vestibular electrical stimulation combined with vestibular rehabilitation in chronic unilateral vestibular hypofunction: A randomized controlled trial

Objectives: To evaluate the effectiveness of vestibular electrical stimulation (VES) combined with vestibular rehabilitation (VR) in patients with chronic unilateral vestibular hypofunction (UVH). Patients and Methods: Forty patients aged 18-65 years, diagnosed with UVH, were ran...

Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio and Coronary Slow Flow: An Integrative Marker of Microvascular Dysfunction

BACKGROUND: Coronary slow flow (CSF) is an angiographic finding characterized by delayed distal vessel opacification despite normal epicardial coronary arteries. Its pathophysiology is multifactorial and involves microvascular dysfunction, endothelial impairment, and chronic infl...

Mid-Term Outcomes of the Ozaki Procedure: A Single-Center Experience

BACKGROUND: To assess the midterm clinical and echocardiographic outcomes of the Ozaki (aortic valve neocuspidization (AVNeo)) procedure performed at a single center. METHODS: A total of 258 patients who underwent the AVNeo procedure between February 2019 and February 2025 were r...

Early Hemogram-Derived Inflammatory Indices Do Not Independently Predict Hospital Stay in Children with Human Bocavirus Detected by Polymerase Chain Reaction

Background/Objectives: Human bocavirus (HBoV) is frequently detected by polymerase chain reaction (PCR) in respiratory samples from children with acute respiratory tract disease, but prolonged viral DNA persistence and frequent co-detection complicate interpretation of its clinic...

Labor Management and Neonatal Outcomes in Term Isolated Oligohydramnios Defined by the Single Deepest Vertical Pocket: A Retrospective Cohort Study

Background/Objectives: The clinical significance of isolated oligohydramnios at term may depend on the measurement method used. We assessed whether isolated oligohydramnios at term, defined by a single deepest vertical pocket (SDVP) below 2 cm, is associated with labor management...

Management of metastatic spinal disease in low- and middle-income countries: an international survey of practices and challenges in Latin America

Spinal metastases impose urgent diagnostic and therapeutic demands; however, evidence from low- and middle-income countries (LMICs) in Latin America is sparse. We aimed to characterize real-world practices, access gaps, and priorities to in-form context-adapted guidelines. We con...

SOX17 and TRPS1 in Müllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions

Background Malignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing Müllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because o...

Risk Factors for Extended-Spectrum β-lactamase, Carbapenem, and Colistin Resistance Among Enterobacterales Bloodstream Infections in Intensive Care Units

Enterobacterales bloodstream infections (E-BSIs) in intensive care units (ICUs) are increasingly complicated by antimicrobial resistance. This retrospective study evaluated resistance patterns and phenotype-specific risk factors for extended-spectrum β-lactamase (ESBL) production...

Adult Mixed Epithelial and Stromal Tumor of the Kidney Harbors Recurrent Whole Chromosome 12 Gain

Mixed epithelial and stromal tumor (MEST), including adult cystic nephroma (CN), is an uncommon benign renal neoplasm that mostly occurs in middle-aged women. To date, a comprehensive molecular genetic investigation of MEST and/or adult CN has not been performed. Fourteen archiva...

Non-Invasive Skin Imaging Techniques for Diagnosing and Monitoring Mycosis Fungoides: A Comprehensive Review

Mycosis fungoides, the most common primary cutaneous T-cell lymphoma, presents notable diagnostic challenges. In its early stages, it may resemble inflammatory dermatoses both clinically and histologically, causing delays in diagnosis. These factors can lead to treatment delays,...

Salvage Autologous Stem Cell Transplantation in Relapsed/Refractory Multiple Myeloma: Long-Term Efficacy and Safety Outcomes from a Single-Center Real-World Cohort

Background: The role of salvage autologous stem cell transplantation (ASCT) in relapsed/refractory multiple myeloma (R/R MM) is being reconsidered in the era of novel immunotherapies. We evaluated the long-term efficacy and safety of salvage ASCT in a real-world single-center coh...

Validity and reliability of the pica, ARFID and rumination disorder interview- ARFID questionnaire (PARDI-AR-Q) in Turkish adults

Avoidant/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a clinically significant eating disorder across the lifespan, yet psychometrically validated assessment tools in non-English-speaking adult populations remain scarce. The Pica, ARFID and Rumination Di...