Medizinische Hochschule Hannover

Analysis of marketing authorizations, withdrawals, and refusals by the European Medicines Agency (EMA): trends in approval procedures 1995–2025

The European Medicines Agency (EMA) is an institution of the European Union (EU), responsible for the authorization and pharmacovigilance of medicinal products. In our study, we present a systematic analysis of the 1,985 centralized EMA marketing authorization procedures (MAP) be...

Behind the photographs: Close relations between German pharmacologists and the British Pharmacological Society in the 1930s observed through the diary of Wolfgang Heubner

In the 1930s, the British Pharmacological Society was founded and rapidly established itself, with Sir Henry Dale, Harold Burn and Ernest Verney playing leading roles. At the same time, with the rise of National Socialism in Germany, many pharmacologists were persecuted for their...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Re-examining the pain–depression vicious cycle in knee osteoarthritis: a random-intercept cross-lagged panel analysis

Abstract Background Pain and depression frequently co-occur in knee osteoarthritis (OA), traditionally viewed as a vicious cycle in which each worsens the other over time. However, conventional cross-lagged models cannot separate stable differences between individuals from real y...

LDL hypercholesterolemia in children: genetic influence and response to lifestyle advice - follow-up of the Fr1dolin-trial

BACKGROUND AND AIMS: Although familial hypercholesterolemia (FH) is common and associated with significant cardiovascular morbidity, screening programs are scarce. Furthermore, the effectiveness of nutritional advice for parents on children's LDL cholesterol (LDL-C) levels is unc...

Twelve-Month Outcomes After Hearing Rehabilitation With an Active Middle Ear Implant and Latest Generation Vibroplasty Couplers in Adults And Children: A Prospective Multicenter Study

OBJECTIVE: To evaluate the audiological efficacy, patient-reported outcomes, and safety of an active middle ear implant (AMEI) in children and adults with distinct coupling options. STUDY DESIGN: Prospective, longitudinal, multicenter, noninterventional observational study with r...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Court rulings on medication errors in Germany: focus on heparin, acetylsalicylic acid, and oxytocin

Abstract Medication errors remain a challenge in the pharmacological treatment of patients. To improve the safety of drug therapy, 197 publicly accessible court rulings from Germany were systemically analyzed in various dimensions according to the PRISMA 2020 statement. Particula...

Stereotypes about tourette syndrome and associations with social media use: results from a large-scale german population survey

Abstract Misunderstandings about tic disorders are common in both the media and the genreal public. However, no large-scale population-based study has investigated public knowledge and stereotypes about tic disorders. We conducted such a survey about knowledge and stereotypes abo...

History of worsening heart failure and outcomes with vericiguat in ambulatory HFrEF: an exploratory post-hoc analysis of VICTOR

Stefan Störk, Javed Butler, Caroline Morbach, Fabian Kerwagen, Johann Bauersachs, Ephraim B Winzer, Justin Ezekowitz, Carolyn S P Lam, Inga Bayh, Stefan He

Metabodeconplus—An R Package for Automated Deconvolution and Alignment of 1D NMR Metabolomics Data

Background: In one-dimensional NMR spectra of complex biofluids such as urine and plasma, extensive signal overlap obscures individual metabolite signals. Resolving this overlap by deconvolution is only the first step: turning a set of spectra into a table for subsequent statisti...

The economic impact of pediatric RSV-related lower respiratory tract infection in Germany: evidence from the PAPI study

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants and young children. While considerable research has described the clinical burden and direct medical costs of RSV in Germany, the broader economic impact...

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues and the tumor microen...

State of development of regional hospice and palliative care networks in Germany and a descriptive comparison of the role of coordination: results of an online survey using a maturity model

Abstract Background Regional hospice and palliative care networks (RHPCNs) aim to establish frameworks for care-management level collaboration between end-of-life care providers within specific regions. Since 2022, political support for RHPCNs in Germany has been bolstered by a n...

The outpatient economic burden of respiratory syncytial virus infection in adults aged ≥ 60 years in Germany: results from the BUCOSS study

Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults aged ≥ 60 years, but data on its outpatient epidemiology and societal costs remain limited. Methods BUCOSS was a prospective observational study conducted over 3...

Diagnostic potential of OCTA for early detection of diabetic retinopathy: A literature review

Background Early detection of diabetic retinopathy (DR) is crucial for preventing blindness. Optical coherence tomography angiography (OCTA) offers a non-invasive method for visualizing retinal microvasculature and may facilitate earlier detection of DR. This systematic review ev...

Gender analysis of the authors of the German-language pharmacy journal Pharmakon from 1972 to 2021

Abstract Women tend to be underrepresented in almost all scientific fields in Germany. This study analyses publications of scientists in a German pharmaceutical non-peer-reviewed journal over a period of 50 years (1972–2021). The journal Pharmakon (previously named Pharmazie in u...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Depressive symptoms in amyotrophic lateral sclerosis: associations with quality of life, disease progression and perceived social support—a German multicenter study

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease. Patients with ALS are at increased risk of developing depressive symptoms. A clearer understanding of the associations between depressive symptoms, disease progression, heal...