Medizinische Hochschule Hannover

Volumetric Wear of Highly Cross-Linked Polyethylene Sockets in Total Hip Arthroplasty Differs Among Brands: A Retrieval Study

Outcomes after total hip arthroplasty (THA) remain limited by wear and wear particle reaction. Although highly cross-linked polyethylene (HXLPE) mitigated this issue, there are major differences among the various brands available. This study quantified, for the first time, the vo...

Effects of secondary factor VIII prophylaxis on joint and bone health in a hemophilia A mouse model

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Cardiovascular toxicity of BTK inhibitors: comparing what can be compared

Annamaria Brioli; Cardiovascular toxicity of BTK inhibitors: comparing what can be compared, European Heart Journal – Cardio-Oncology, , aabag012, https://

Insights from Germany’s Largest Diabetes Camp for Young People: Who Attends, Why, and What Do They Gain?

Background: Adolescents and young adults (AYA) with type 1 diabetes face unique challenges in diabetes management due to hormonal fluctuations, lifestyle changes, and the transition to adult healthcare. Despite this, participation in traditional diabetes education courses is low....

Qualification of a Swellable Hydrogel–Silicone Bimorph for Implantable Actuation

To improve the structural adaptability and biological suitability of cochlear implant electrode carriers, this study systematically develops and evaluates novel 3D-printed, swellable hydrogel–silicone composites. A vinylphosphonic acid–acrylamide hydrogel powder (VPA-AAm) was pre...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Novel peritoneal catheters with silver particles lower rates of peritonitis in patients with cirrhosis and refractory ascites

Background Treatment options for refractory ascites (RA) in cirrhosis are scarce. When TIPS insertion is contraindicated, tunneled peritoneal catheters (cPeCa) offer an alternative treatment. However, cPeCa are associated with high incidences of infection-related complications. N...

Adoption of, attitudes towards, and perceived challenges of digital health in hospice and palliative care among professionals in Germany: a national cross-sectional web-based survey

Abstract Background Digital health technologies may support communication, symptom management, continuity of care, and access to services in hospice and palliative care. National data on their adoption, on professionals’ attitudes, and on perceived barriers are scarce. We examine...

Reliable multimodal signals for in-vehicle heartbeat detection

Abstract Continuous and unobtrusive cardiac monitoring during driving is medically attractive but technically challenging due to motion artifacts, contact variability, and changing illumination. Building on our previously developed multimodal sensing platform that integrates stee...

A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile

Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the underlying mechanism remained...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Veterinarians on the margins? A qualitative interview study on the professional identity of official veterinary inspectors working in slaughterhouses in Austria

Abstract Background Official veterinary inspectors play a central role in ensuring food safety and animal welfare within slaughterhouses, yet their role as a distinct group within the veterinary profession remains underexplored. This article uses the concept of professional ident...

Dynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa

Post-transcriptional transfer RNA (tRNA) modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine time-resolved nanopore tRNA...

Thirty Years and Beyond: Long-term Outcomes After Liver Transplantation at a Single Center: Progress, Challenges, and Future Implications.

Background: The liver transplantation (LT) program was established at Hannover Medical School in 1972. The aim of the study was to assess graft and patient survival, organ function, and active life throughout ≥3 decades after LT, with a special focus on recipients surviving ≥30 y...

Automated SSIM regression for detection and quantification of motion artefacts in brain MR images

Abstract Motion artefacts in magnetic resonance brain images can have a strong impact on diagnostic confidence. The assessment of MR image quality is fundamental before proceeding with the clinical diagnosis. Motion artefacts can alter the delineation of structures such as the br...

Two cases of an imatinib-sensitive PRKG2::PDGFRA-positive chronic myeloid neoplasm with basophilia

The clinical and morphological phenotype of myeloid/lymphoid neoplasms with tyrosine kinase (TK) gene fusions (MLN-TK) is influenced by both the TK and the partner gene [ 1 ]. Here, we report on two patients with an initial diagnosis of a chronic myeloid neoplasm with prominent b...

Apparentness of Unseen Rejection Episodes Post Lung rLTx Is Reliably Enabled by ddcfDNA Detection

ABSTRACT ddcfDNA emerged as a biomarker for post‐transplantation management strategies. Lung retransplant recipients represent a particularly vulnerable patient population with an increased risk of allograft injury. The demand for understanding if ddcfDNA levels differ between pr...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Emotion regulation in compulsive sexual behavior disorder: Divergence between self-report and neural measures

Background With Compulsive Sexual Behavior Disorder (CSBD) forming a new category in the ICD-11, a discussion arose as to whether deficits in emotion regulation are part of the symptoms. Aims This study aims to further our knowledge on emotion regulation in CSBD by comparing a cl...