Medizinische Hochschule Hannover

Emotion regulation in compulsive sexual behavior disorder: Divergence between self-report and neural measures

Background With Compulsive Sexual Behavior Disorder (CSBD) forming a new category in the ICD-11, a discussion arose as to whether deficits in emotion regulation are part of the symptoms. Aims This study aims to further our knowledge on emotion regulation in CSBD by comparing a cl...

Coordinated neural progenitor adaptations contribute to primate neocortical downscaling

Most primates have a large, highly folded (gyrencephalic) neocortex, a feature present in the primate common ancestor. In contrast, several New World monkey species display a comparatively small and largely smooth, unfolded (lissencephalic) neocortex. One prominent example is the...

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

Importance Coagulopathy in the context of COVID-19 is a major threat due to deep vein thromboses and pulmonary embolisms. Objective To assess whether therapeutic anticoagulation on top of standard of care (SOC) compared with prophylactic anticoagulation as part of SOC can improve...

Epidemiology of the hepatitis delta virus (HDV) in West Africa: a systematic review

Background Hepatitis delta virus (HDV) represents the most severe form of chronic viral hepatitis yet remains neglected in resource-limited settings. West Africa, with high hepatitis B virus (HBV) endemicity and unique sociocultural risk factors, represents a critical region for...

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Agentic AI, medical morality and the transformation of the patient–physician relationship

Agentic artificial intelligence (AI) is an emerging development in the digital transformation of healthcare. Unlike conventional generative AI, agentic AI systems can perform autonomous, goal-directed actions and coordinate complex tasks. They promise to support or even collabora...

Sex-specific patterns of symptom burden, psychological distress, and work productivity impairment in post-acute sequelae of COVID-19: a 10-month dynamic cohort study

Abstract Background A considerable proportion of patients experience post-acute sequelae of COVID-19 (PASC). Increasing evidence suggests sex-related differences, yet systematic longitudinal analyses remain limited. This study aimed to examine sex-specific differences in symptoms...

Severe antipsychotic-associated gastrointestinal hypomotility: AMSP pharmacovigilance data from 333,175 psychiatric inpatients

Abstract Background Severe courses of gastrointestinal hypomotility (GIH) are rare but potentially life-threatening adverse drug reactions (ADRs) associated with antipsychotic drugs (APDs). This study aimed to investigate the frequency, clinical characteristics, and associated dr...

German translation and initial measurement properties of the Q-TFA in transfemoral bone-anchored prosthesis users

Abstract Background To translate and cross-culturally adapt the Questionnaire for Persons with a Transfemoral Amputation (Q-TFA) into German and evaluate initial measurement properties in adults with unilateral transfemoral amputation using a transcutaneous bone-anchored prosthes...

Patient-reported outcomes after surgical treatment of spontaneous intracranial hypotension: a cross-sectional study

Abstract Background Spontaneous intracranial hypotension (SIH) can cause substantial functional and psychosocial impairment, but patient-reported outcomes after surgical treatment remain incompletely understood. This study aimed to describe postoperative symptom burden, functiona...

Cocaine, cannabis, champagne—pharmacological and toxicological references in the lyrics of the German rapper Haftbefehl: a content analysis

In popular music, references to (illicit) drugs are widespread and may influence attitudes and behaviors in relation to substance use and abuse, especially among younger generations. While substance-related content in international pop and rap music has been studied extensively,...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

A Scoring System Contributing to the Detection of Radiation Pneumonitis in Elderly Patients with Lung Cancer—Results of the POLCAR Trial

Background/Objectives: A symptom-based scoring system (0–9 points) for the identification of radiation pneumonitis was previously evaluated in lung cancer patients without age restrictions. A threshold of five points appeared optimal to detect pneumonitis. Since elderly patients...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

Differentiating therapeutic use and potential impairment in the forensic interpretation of valsartan concentrations in road traffic offenders

Based on the presented case, general challenges in the interpretation of cardiovascular drug concentrations in the context of active participation in road traffic are discussed. Particular emphasis is placed on the assessment of valsartan concentrations, for which no clearly defi...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Comparison of High‐Sensitivity Troponin T Versus N‐Terminal Pro‐B‐Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery

Background Preoperative hs‐TnT (high‐sensitivity cardiac troponin T) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for risk prediction in noncardiac surgery. While the European Society of Cardiology recommends hs‐TnT, American Cardiology and European anesthes...