Medizinische Hochschule Hannover

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues and the tumor microen...

The economic impact of pediatric RSV-related lower respiratory tract infection in Germany: evidence from the PAPI study

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants and young children. While considerable research has described the clinical burden and direct medical costs of RSV in Germany, the broader economic impact...

State of development of regional hospice and palliative care networks in Germany and a descriptive comparison of the role of coordination: results of an online survey using a maturity model

Abstract Background Regional hospice and palliative care networks (RHPCNs) aim to establish frameworks for care-management level collaboration between end-of-life care providers within specific regions. Since 2022, political support for RHPCNs in Germany has been bolstered by a n...

The outpatient economic burden of respiratory syncytial virus infection in adults aged ≥ 60 years in Germany: results from the BUCOSS study

Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults aged ≥ 60 years, but data on its outpatient epidemiology and societal costs remain limited. Methods BUCOSS was a prospective observational study conducted over 3...

Diagnostic potential of OCTA for early detection of diabetic retinopathy: A literature review

Background Early detection of diabetic retinopathy (DR) is crucial for preventing blindness. Optical coherence tomography angiography (OCTA) offers a non-invasive method for visualizing retinal microvasculature and may facilitate earlier detection of DR. This systematic review ev...

Gender analysis of the authors of the German-language pharmacy journal Pharmakon from 1972 to 2021

Abstract Women tend to be underrepresented in almost all scientific fields in Germany. This study analyses publications of scientists in a German pharmaceutical non-peer-reviewed journal over a period of 50 years (1972–2021). The journal Pharmakon (previously named Pharmazie in u...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Depressive symptoms in amyotrophic lateral sclerosis: associations with quality of life, disease progression and perceived social support—a German multicenter study

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease. Patients with ALS are at increased risk of developing depressive symptoms. A clearer understanding of the associations between depressive symptoms, disease progression, heal...

Early Effects of Communities That Care on System Transformation: a Non-randomized Community Trial in Germany

Community coalition approaches such as Communities That Care (CTC) are regarded as key strategies for translating prevention science into community-level improvements in youth outcomes. It was shown that CTC improves three system transformation outcomes. The present study aimed t...

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompa...