Mayo Clinic

APC/C−CDH1 suppresses AROS-mediated protection against DNA damage-induced senescence by ubiquitination

Anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle by destruction of target proteins ubiquitination. However, understanding the control of APC/C has remained elusive. We identify APC2, the catalytic core subunit of APC/C, as a binding partner of active regulato...

Melanoma in Skin of Color: Diagnostic Challenges, Overdiagnosis, and Emerging Tools

Melanoma in skin of color (SOC), defined as Fitzpatrick skin tones IV-VI, presents unique epidemiologic, diagnostic, and therapeutic challenges compared to non-Hispanic White (NHW). Although SOC patients have a lower incidence of melanoma, they experience higher melanoma-specific...

One-Stage Versus Staged Palatal Repair in Unilateral Cleft Lip and Palate: Longitudinal Maxillofacial Growth, Speech, and Postoperative Outcomes

Objective This study aimed to compare longitudinal cephalometric growth, speech outcomes, and secondary surgeries after 1-stage versus 2-stage palatoplasty in patients with non-syndromic unilateral cleft lip and palate (UCLP). Design Retrospective single-institution cohort study....

Modulation of Endoplasmic Reticulum Stress via CEBPB : A Potential Molecular Link to Therapeutic Action in Substance Use Disorders

AIMS: Opioid use disorder remains a major public health crisis in the United States, driven largely by rising overdose deaths from synthetic opioids, such as fentanyl. Emerging population-level evidence suggests that GLP-1 receptor agonists (GLP-1RAs) may reduce overdose risk. Ho...

Health Care’s Identity Crisis—Is Medicine Still a Profession?

This Perspective discusses the misalignment physicians face between their professionalism-based values and the conditions of practice that are influenced by pressures from market, managerial, and platform logics, and offers suggestions to align practice conditions and professiona...

Surgical outcomes of trabecular micro-bypass minimally invasive glaucoma surgery devices in eyes with high myopia: a 24-month retrospective multicenter cohort study

BACKGROUND: To describe outcomes of two trabecular bypass minimally invasive glaucoma surgery (MIGS) devices in highly myopic (HM) eyes with glaucoma up to 24 months postoperatively. METHODS: A retrospective, observational multicenter study of HM eyes (phakic refractive spherical...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Mixed Neuroendocrine Carcinoma and Adenocarcinoma in a Patient With Ileal Pouch-Anal Anastomosis

ABSTRACT Neoplasia of the ileoanal pouch is uncommon, occurring in fewer than 1% of patients. Neuroendocrine carcinoma (NEC) is a rare neoplastic complication and can be difficult to diagnose due to symptoms overlapping with inflammatory pouch disorders. We describe a 36-year-old...

NCCN Risk Groups Do Not Predict Adverse Pathology or Oncologic Outcomes Among Patients With Grade Group 1 Prostate Cancer in the MRI Era

ABSTRACT Background Prior studies in the pre‐MRI era suggest that patients with NCCN Intermediate and High Risk Grade Group 1 prostate cancer (GG1 PCa) on biopsy have increased risk for adverse oncologic outcomes. However, prostate MRI has altered patient selection for biopsy and...

Anti-Fungal and Toxicology Assessment of ISFP10, an Inhibitor of Fungal Phosphoglucomutase (PGM)

BACKGROUND AND OBJECTIVE: The novel small molecule ISFP10 inhibits fungal phosphoglucomutase (PGM) activity in Aspergillus fumigatus and Pneumocystis spp. With 50-fold selectivity over the human isoform, conferred by a conserved cysteine residue present in several pathogenic fung...

Integrating Nonpharmacological Options Into Perioperative Pain Care

Importance Postoperative pain is commonly treated with opioids, which may contribute to unnecessary opioid-related harms. Scalable approaches to integrate recommended nonpharmacologic pain care could reduce opioid exposure while improving or at least preserving functional recover...

Intratunnel Anchor Fixation and Transtibial Pull‐Through Repair Show Comparable Short‐Term Outcomes After Meniscus Root Repair: A Propensity‐Matched Comparative Study

Purpose To compare short‐term outcomes of intratunnel anchor fixation versus transtibial pull‐through repair for meniscus root tears with a minimum of 12‐month follow‐up. Methods Patients who underwent primary meniscus root repair between 2011 and 2024 at a single institution wer...

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Reducing Ultraprocessed Foods From the Diets of Patients With Depression

This pilot crossover trial assesses the feasibility and acceptability of removing ultraprocessed foods from the diets of patients with major depressive disorder.

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Graph-Enhanced Retrieval-Augmented Generation for Postoperative Patient Question Answering: A Comparative Evaluation of Knowledge Graph, Retrieval-Augmented Generation, and Hybrid GraphRAG Approaches

Background: Reliable access to postoperative guidance between clinic visits remains inconsistent, and the usefulness of large language models depends on how clinical knowledge is structured and retrieved. Knowledge graph-only (KG-only), vector retrieval-augmented generation (RAG-...

Sotatercept Improves Right Heart Mechanics Despite Reduced Myocardial Contractility in Pulmonary Arterial Hypertension: A Prospective Exercise Hemodynamic Study

BACKGROUND: The right ventricular (RV) response to pressure overload is a crucial determinant of outcomes in pulmonary arterial (PA) hypertension. Sotatercept improves clinical outcomes, but its effects on the right ventricle have been inconsistent. We evaluated the effects of so...

Gallbladder Malignancy: From Diagnosis to Staging

Abstract Gallbladder (GB) cancer is an aggressive biliary malignancy with a silent clinical course, leading to delayed diagnosis and poor outcomes. Early detection and accurate staging are pivotal for guiding management, yet diagnosis remains challenging due to overlapping imagin...

The effect of mask choice on adherence to positive airway pressure treatment for obstructive sleep apnea in adults

PURPOSE OF REVIEW: Mask choice is among the few modifiable determinants of positive airway pressure (PAP) effectiveness in adults with obstructive sleep apnea OSA), yet selection is often shaped by convention, habit, or local inventory rather than evidence. We review recent liter...