Mayo Clinic

Scuba-related injuries presenting to United States emergency departments: paediatric and adult patterns

Introduction: Scuba diving is a popular sport that carries risks unique to the underwater environment. Paediatric emergency department presentations for scuba diving injuries are incompletely characterised, particularly in comparison with adults. Methods: We retrospectively analy...

Pancreatic Cancer Screening and Early Detection: Where Are We Now?

Screening for pancreatic cancer with imaging techniques in high-risk individuals—including patients with a genetic predisposition, a family history, or precursor lesions—is critical for improving early detection and survival outcomes, and multimodal strategies that integrate AI-e...

Cost‐Effectiveness of Early Empirical Antibiotic Cessation in Pediatric High‐Risk Febrile Neutropenia

PURPOSE: for children with high-risk febrile neutropenia (FN). In this prospective trial-based economic evaluation, we aimed to estimate the healthcare resource utilization and cost-effectiveness of early discontinuation of EAT versus continuation of EAT in children with high-ris...

Artificial Intelligence–Based Detection of ARIA on MRI During Alzheimer Disease Therapy: Expert Opinion on Responsible Clinical Integration

Amyloid-targeted monoclonal antibody therapies have introduced a new era in the treatment of early Alzheimer disease. However, their use has increased the importance of detecting and monitoring amyloid-related imaging abnormalities (ARIA) on MRI, as such findings may influence tr...

Non‐Invasive Imaging Assessment of Liver Fibrosis

Chronic liver disease (CLD) is a major cause of global morbidity and mortality, with outcomes closely linked to the severity of liver fibrosis. While liver biopsy has historically been the reference standard for fibrosis staging, its invasiveness, sampling variability and limited...

Patellar Tendon‐Lateral Trochlear Ridge Distance Is More Specific Than Tibial Tubercle‐Trochlear Groove for Patellofemoral Instability

PURPOSE: To assess the reliability, predictability, and discriminative capacity of 3 anatomic measurements, tibial tubercle-trochlear groove (TT-TG), tibial tubercle-posterior cruciate ligament, and patellar tendon-lateral trochlear ridge (PT-LTR), where PT-LTR may offer a comple...

A Reassessment of Prophylactic Antibiotics in Low‐Infection‐Risk Electrophysiology Procedures

ABSTRACT Certain electrophysiology (EP) procedures are associated with minimal tissue disruption and do not involve permanent transvenous leads. As a result, these interventions carry a lower risk of device‐ or procedure‐related infection. These procedures include placement of im...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expan...

Single Anesthetic Approach to Diagnosis, Staging and Treatment of Lung Cancer

The conventional workup for suspected early-stage lung cancer requires multiple visits, anesthetics, and procedures. Single anesthetic event lung cancer surgery integrates shape-sensing robotic bronchoscopy, cone-beam CT, rapid on-site cytologic evaluation (ROSE), endobronchial u...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Why Metrics Matter in Thyroid Eye Disease

Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the clinical me...

A Novel De Novo STAG1 Variant at the RAD21 Binding Interface Is Associated With Hypoglycemia, Recurrent Fever, Immunodeficiency and Features of Classical Cohesinopathies

The cohesin complex, composed of SMC1, SMC3, RAD21, and STAG1/STAG2, is essential for chromosome cohesion, DNA repair, and transcriptional regulation. Pathogenic variants in cohesin components cause cohesinopathies. The classical characteristics of cohesinopathies include develop...

Colour Doppler ultrasound assessment of retrobulbar hemodynamics and static retinal vessel analysis in Sjögren’s disease: the SICARD cohort

Abstract Objectives To assess, for the first time, macrovascular, medium-calibre vessel, and microvascular damage in Sjögren’s disease (SjD) using carotid greyscale ultrasound (GSUS), retrobulbar colour Doppler ophthalmic artery (OA) ultrasound (RCDUS), and static retinal vessel...

Implementing shared decision making in the everyday work of clinicians providing cardiovascular preventive care: evaluating the implementation of an electronic encounter tool in three U.S. healthcare systems

Shared decision making (SDM) is guideline-recommended for primary prevention of cardiovascular (CV) disease, but there are barriers to routine adoption of tools to promote SDM. This pragmatic trial evaluated the effect of tailored strategies on implementation of an SDM tool ( CV...

The Clinical Anatomist: From Anatomical Competency to Professional Identity

ABSTRACT Anatomy remains among the most resilient foundations of medicine, yet the professional who applies it most substantively to patient care has no defined professional identity, and the designation clinical anatomist is presently adopted by anyone who wishes to claim it. We...

Longitudinal Data from a Large, Multi-Target Stool DNA Colorectal Cancer Screening Program

Background & Aims: Multi-target stool DNA (mt-sDNA) is an established stool-based colorectal cancer screening test, yet long-term performance is not well-described. We evaluated follow-up colonoscopy rates & quality, neoplasia yield, and repeat-testing adherence over 10 years wit...

Evaluation of current practices and communication surrounding sudden unexpected death in epilepsy ( SUDEP ): A survey analysis of healthcare practitioners

Abstract Objective To characterize healthcare providers' awareness and education regarding SUDEP and their approaches to SUDEP counseling. Methods A voluntary, observational 14‐question survey was administered at the 2024 American Epilepsy Society Annual Meeting to healthcare pro...

Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition with diverse etiologies and clinical presentations. Yet, a consensus of subtypes is lacking in MASLD. Based on latent class analysis of significant MASLD-related clinical variables, we i...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...