Mayo Clinic in Arizona

Renal Cortical Siderosis: Imaging Findings and Clinical Relevance

Abstract Renal cortical hemosiderosis is the accumulation of iron in the renal cortex. On MRI, this can be inferred by marked cortical T2 hypointensity and loss of signal on in-phase imaging relative to opposed-phase imaging. Although classically associated with paroxysmal noctur...

Association of the Red Cell Distribution Width–Albumin Ratio with Myocardial Strain, Mortality, and Heart Failure Hospitalization: A Retrospective Cohort Study

Aims: The aims of this study were to evaluate the association between the red cell distribution width (RDW)–albumin ratio (RAR) and subclinical myocardial impairment, as assessed by left ventricular global longitudinal strain (LVGLS), and to examine the relationships between the...

Training the next generation of minimally invasive HPB surgeons: are current fellowships crossing the learning curve?

Abstract Background Minimally invasive surgery (MIS) improved outcomes in hepatopancreatobiliary (HPB) cases, yet adoption is slowed by technical complexity and steep learning curves. This retrospective review sought to characterize MIS training variations across three fellowship...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Selective Limbic and Striatal Atrophy Corresponds to Regional Gene Expression in Leucine‐Rich Glioma‐Inactivated‐1 Immunoglobulin G Autoimmune Encephalitis

Objective To characterize regional brain atrophy patterns, evaluate their association with regional leucine‐rich glioma‐inactivated‐1 ( LGI1 ) gene expression, and identify clinical predictors of hippocampal atrophy in LGI1 autoimmune encephalitis (AE). Methods This study compare...

Biweekly gemcitabine and nab-paclitaxel in advanced pancreatic cancer: a systematic review

Abstract Background Pancreatic cancer is associated with high morbidity and mortality. Gemcitabine plus nab-paclitaxel (GA), along with FOLFIRINOX and NALIRIFOX, is a standard first-line treatment for advanced/metastatic pancreatic ductal adenocarcinoma (mPDAC). However, the stan...

Prognostic implications of complications during VA-ECMO for cardiogenic shock

PURPOSE: Veno-arterial extracorporeal oxygenation (VA-ECMO) provides comprehensive cardiopulmonary support in patients with cardiogenic shock (CS), but may result in complications. While complications rates are known, their impact on risk of death remains largely unknown. METHODS...

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs

Glioblastoma (GBM) is a lethal, treatment-resistant brain cancer characterized by diffuse brain invasion, complex neuron-glioma signaling, and cellular, molecular, and spatial heterogeneity. Surgery is the current mainstay of treatment, aimed at maximizing tumor cytoreduction, de...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

External Adhesive Marker Technique Shows Excellent Reproducibility for Measuring Patellar Tendon‐to‐Lateral Trochlear Ridge Distance on Magnetic Resonance Imaging

Purpose To evaluate the agreement between a simple magnetic resonance imaging‐based measurement method for determining the patellar tendon‐to‐lateral trochlear ridge (PT‐LTR) distance using an external adhesive marker and a previously validated conventional measurement technique....

Ventricular Arrhythmias in Marfan Syndrome: Prevalence and Clinical Correlates in a Multicenter Cohort

BACKGROUND: Ventricular arrhythmias are increasingly recognized in Marfan syndrome, but associated clinical and structural features remain incompletely defined. METHODS: We performed a retrospective multicenter cohort study of 783 adults with confirmed Marfan syndrome at 3 Mayo C...

Demographic-Adjusted Normative Equations for the Oculo-Cognitive Addition Test (OCAT): A Foundation for Individualized Oculo-Cognitive Assessment

Background: Many neurological and cognitive disorders have early oculomotor hallmarks. The Oculo-Cognitive Addition Test (OCAT) is a quick, objective screening tool that measures eye movement and time-based biomarkers of cognitive processing during simple mental addition tasks in...

Prediction of acute mountain sickness occurring at 4554 m using overnight pulse oximetry from lower altitude: A pilot study

Abstract Acute mountain sickness (AMS) affects many individuals ascending to high altitude annually, carrying potential morbidity and mortality risks (e.g., high‐altitude cerebral oedema). The objective of this pilot study was to record overnight pulse oximetry during ascent to 4...

APC/C−CDH1 suppresses AROS-mediated protection against DNA damage-induced senescence by ubiquitination

Anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle by destruction of target proteins ubiquitination. However, understanding the control of APC/C has remained elusive. We identify APC2, the catalytic core subunit of APC/C, as a binding partner of active regulato...

Melanoma in Skin of Color: Diagnostic Challenges, Overdiagnosis, and Emerging Tools

Melanoma in skin of color (SOC), defined as Fitzpatrick skin tones IV-VI, presents unique epidemiologic, diagnostic, and therapeutic challenges compared to non-Hispanic White (NHW). Although SOC patients have a lower incidence of melanoma, they experience higher melanoma-specific...

One-Stage Versus Staged Palatal Repair in Unilateral Cleft Lip and Palate: Longitudinal Maxillofacial Growth, Speech, and Postoperative Outcomes

Objective This study aimed to compare longitudinal cephalometric growth, speech outcomes, and secondary surgeries after 1-stage versus 2-stage palatoplasty in patients with non-syndromic unilateral cleft lip and palate (UCLP). Design Retrospective single-institution cohort study....

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Adjuvant Chemotherapy Is Not Associated With Improved Overall Survival in Patients With Pancreatic Ductal Adenocarcinoma With Persistent Lymphovascular Invasion or Lymph Node Involvement After Neoadjuvant Chemotherapy

ABSTRACT Background and Objectives There is increasing use of neoadjuvant treatment (NAT) for patients with pancreatic adenocarcinoma (PDAC). The role of additional adjuvant chemotherapy (AT) is not well‐defined. This study aims to determine the impact of lymphovascular invasion...

Anti-Fungal and Toxicology Assessment of ISFP10, an Inhibitor of Fungal Phosphoglucomutase (PGM)

BACKGROUND AND OBJECTIVE: The novel small molecule ISFP10 inhibits fungal phosphoglucomutase (PGM) activity in Aspergillus fumigatus and Pneumocystis spp. With 50-fold selectivity over the human isoform, conferred by a conserved cysteine residue present in several pathogenic fung...

Challenges in establishing epidemiological cut-off values for the Burkholderia cepacia complex

ABSTRACT The Burkholderia cepacia complex (BCC) is comprised of 24 species of gram-negative bacteria that cause opportunistic infections. While antimicrobial susceptibility testing (AST) has historically been used to guide treatment for BCC infections, recent work highlighting pr...