Mayo Clinic in Arizona

Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition with diverse etiologies and clinical presentations. Yet, a consensus of subtypes is lacking in MASLD. Based on latent class analysis of significant MASLD-related clinical variables, we i...

Does the National Resident Matching Program Rank List Predict Accreditation College of Graduate Medical Education Trainee Performance Among Multispecialty Pain Medicine Fellows? A Multicenter Study

Abstract Background Training programs seek to match fellows who will perform well during training. The National Resident Matching Program (NRMP) allows programs to choose the most capable trainees, with higher ranked applicants expected to perform better. Pain medicine is one of...

Bronchoscopic Ablation and Intratumoral Therapies for Lung Cancer: Expanding Local Treatment Beyond Surgical Resection

Advances in navigational bronchoscopy, robotic platforms, and intraprocedural imaging have transformed bronchoscopy from a diagnostic modality into a potential therapeutic platform for localized treatment of lung cancer. These developments are particularly relevant for patients w...

Cardinal Lessons in Cardiac Amyloidosis: Diagnostic Pitfalls Across Three Cases: A Case Report

Abstract Background Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy caused by extracellular deposition of misfolded amyloid fibrils within the myocardium, resulting in progressive ventricular wall thickening and heart failure. Transthyretin (ATTR) and immunoglobulin li...

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.

There is increasing recognition of the high prevalence of hereditary predisposition syndromes in patients diagnosed with paraganglioma/pheochromocytoma. It is widely acknowledged that germline pathogenic alterations of the succinate dehydrogenase complex genes (SDHA, SDHB, SDHC,...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

Approximately 30% of Patients Undergoing Knee Cartilage Biopsy Subsequently Undergo Matrix‐Induced Autologous Chondrocyte Implantation at a Mean 4.3‐Year Follow‐Up

Purpose To evaluate implantation rates, time to implantation, and predictors of implantation following matrix‐induced autologous chondrocyte implantation (MACI) biopsy for knee chondral defects. Methods Patients undergoing MACI biopsy or implantation for symptomatic knee chondral...

Prognostic performance of composite PE shock score in comparison and combination with PESI and ESC risk classification: a retrospective cohort study

PESI and ESC risk classification are widely used for early risk stratification of acute pulmonary embolism (PE). The Composite PE Shock (CPES) score has been proposed to better identify normotensive shock. We compared the prognostic performance of PESI, ESC risk class, and CPES....

KRAS in Colorectal Cancer: Tumorigenesis, Surgical Implications and Evolving Treatment Target

Purpose: This review aims to provide an updated overview of Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations in colorectal carcinoma (CRC), focusing on their role in tumorigenesis, prognostic implications, and recent advances in targeted therapy. Major findings: KRAS...

Determinants of Cognitive Change Over 1 Year in Older Adults With Type 1 Diabetes

OBJECTIVE Older adults with type 1 diabetes (T1D) have a greater risk for cognitive decline, highlighting the need to identify risk factors for meaningful cognitive change using brief screening tools suitable for annual wellness examinations. RESEARCH DESIGN AND METHODS This stud...

Day-time split study for management of obstructive sleep apnoea: Proof of concept study

Objective: Waiting time for diagnosis and treatment of obstructive sleep apnoea (OSA) is increasing due to a lack of adequate amount of sleep labs. This study was done to find out the feasibility of daytime split Polysomnography (PSG) in patients with excessive daytime sleepiness...

Functional Stability Measured by Changes in the 6-min Walk Test in Patients Treated with Tafamidis Versus Placebo: Post hoc Analysis from ATTR-ACT

Tafamidis, a transthyretin stabilizer for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM), significantly reduced the decline in 6-min walk test (6MWT) distance, a marker of functional stability, compared with placebo in the pivotal study ATTR-ACT. In this post hoc...

Pediatric Mycosis Fungoides and Hydroa Vacciniforme Lymphoproliferative Disorder

Patients most often present with hypopigmented patches, though folliculotropic disease is also common. Prognosis is usually excellent. Most patients are diagnosed with early-stage disease, and less than 5% of cases progress to late-stage disease. Pediatric MF can be difficult to...

Does Race Influence Velopharyngeal Structure Size and Velar Stretch During Sustained Phoneme Production in Children?

Purpose: Differences in the size of velopharyngeal structures across racial groups at rest have been described in the literature, with race influencing adenoid thickness, pharyngeal depth, effective velar length, and velar length. The purpose of this study was to examine differen...

Reconceptualizing Cerebral Palsy as a Lifelong Condition Characterized by Systemic and Accelerated Biological Decline

Cerebral palsy (CP), the most common childhood-onset disability worldwide, affects an estimated 50 million individuals globally. Although most individuals with CP are adults, CP education and training remain heavily concentrated within pediatric subspecialties, contributing to su...

Older Age, STAG2 , and DNMT3A Mutations Predict Superior Posttransplant Survival in Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Hypomethylating Agents

ABSTRACT Venetoclax (Ven) plus hypomethylating agents (HMA) is standard frontline therapy for newly diagnosed AML (ND‐AML) patients unfit for intensive chemotherapy and is also considered in younger, fit patients. However, consolidation with allogeneic stem cell transplant (ASCT)...

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

Severe Infections as a Novel Risk‐Enhancing Factor for Incident Heart Failure

ABSTRACT Background Severe infections might be a novel risk marker for incident heart failure (HF). We examined the relationship between infection-related hospitalization (IRH) and HF in a large clinical health system and assessed whether adding IRH improved predictive utility of...

Clinical Outcomes of HIF-2α inhibition in Von Hippel-Lindau Disease: A Multicenter Real-World Study.

BACKGROUND AND OBJECTIVE: Management of von Hippel-Lindau (VHL) disease is challenging due to multisystem involvement and limited systemic treatment options. Belzutifan has shown promising efficacy in clinical trials; however, real-world data remain limited. We aimed to evaluate...