Mayo Clinic in Arizona

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

Severe Infections as a Novel Risk‐Enhancing Factor for Incident Heart Failure

ABSTRACT Background Severe infections might be a novel risk marker for incident heart failure (HF). We examined the relationship between infection-related hospitalization (IRH) and HF in a large clinical health system and assessed whether adding IRH improved predictive utility of...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Clinical Outcomes of HIF-2α inhibition in Von Hippel-Lindau Disease: A Multicenter Real-World Study.

BACKGROUND AND OBJECTIVE: Management of von Hippel-Lindau (VHL) disease is challenging due to multisystem involvement and limited systemic treatment options. Belzutifan has shown promising efficacy in clinical trials; however, real-world data remain limited. We aimed to evaluate...

Clinical outcomes of minimally invasive liver resection in patients with cirrhosis: A systematic review and meta-analysis

Backgrounds/Aims: The impact of cirrhosis on outcomes following minimally invasive liver resection (MILR) remains debated. This meta-analysis evaluates the effect of cirrhosis on perioperative outcomes in patients undergoing MILR. Methods: PubMed, Embase, CINAHL, Scopus, and Web...

EngineeredNatural Killer Cell Derived-ExtracellularVesicles: An Acellular Immunotherapy with Cytotoxic Effects in SNU-1079Human Cholangiocarcinoma Cells

Abstract The use of natural killer (NK) cells for the treatment of solid tumors such as cholangiocarcinoma has been hindered by challenges related to cell production, persistence and trafficking, as well as by reduced efficacy within an immunosuppressive tumor microenvironment. A...

Global Transcriptional Differences in Staphylococcus aureus Biofilm-Associated Genes in a brpR Mutant Compared to Wild-Type Strain

Background: Staphylococcus aureus causes bloodstream and skin infections in humans. The prevalence of multidrug-resistant S. aureus strains means new antibiotics are needed. A novel antimicrobial drug named SK-03-92, a synthetic aromatic organic stilbenoid compound, kills S. aure...

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding...

Human‐Scale Rotating Magnetic Field Delivery With Permanent Magnets Under Anatomic and Robotic Constraints

Rotating magnetic fields (RMFs) are widely used to actuate untethered microrobots, yet delivering clinically relevant RMFs at human scale remains challenging. Here, we create a quantitative framework for human‐scale RMF delivery using robot‐arm‐mounted permanent magnets. It links...

CONRep: Uncertainty-Aware Vision-Language Report Drafting Using Conformal Prediction

The objective of this study is to quantify uncertainty in vision-language model (VLM)-based automated radiology report drafting (ARRD) to support trustworthy clinical deployment. In this study, we developed CONRep in two settings: label-based and sentence-based. In the label-base...

Disentangling the Hemodynamic Effects of A-Wave Loss and Cardiac Output Reduction in Atrial Fibrillation

PURPOSE: Atrial fibrillation (AF) increases thromboembolic risk, yet the relative hemodynamic contributions of A-wave loss, cardiac output (CO) reduction, and patient-specific atrial geometry remain incompletely understood. This study aimed to isolate the hemodynamic consequences...

Multidimensional Experimental Characterization of Lumbar Spinal Deformity

PURPOSE: Spinal deformities and motions of the spinal joints are rarely confined to a single anatomical plane. Yet diagnosis of such deformities and characterizations of their biomechanical behavior under load are often limited to two-dimensional methods of analysis. This study p...

Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells

Small interfering RNAs (siRNA) are powerful tools to target cellular protein expression, making them promising candidates for therapeutic applications. siRNA-based approaches to target detrimental mechanisms in airway diseases such as asthma and COPD are highly appealing. However...

Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications

Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...

Cardiotoxicity and safety of zanubrutinib versus chemoimmunotherapy in chronic lymphocytic leukemia: a real-world retrospective cohort study using the TriNetX registry

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in the Western countries. Ibrutinib, a first-generation Bruton’s tyrosine kinase (BTK) inhibitor, is commonly used for relapsed/refractory CLL but is associated with cardiovascular adv...

Plain Radiograph Use in Pediatric Blunt Trauma Patients with Suspicion for Cervical Spine Injury: A Prospective Observational Analysis of the Western Pediatric Cervical Spine Study

BACKGROUND: Despite guideline support for plain radiography (XR) in low-risk pediatric blunt trauma, CT remains the predominant imaging modality for cervical spine evaluation, increasing radiation exposure. We evaluated contemporary XR utilization and its diagnostic performance i...

Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis

Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Although nanomedicine has advanced systemic...

Intra-Articular Monoclonal Antibodies in Temporomandibular Joint Disorders: Current Evidence

Immune-mediated temporomandibular joint disorders involve cytokine-driven inflammation and may represent a target for biologic therapy. This paper summarizes the evidence on intra-articular monoclonal antibody administration in temporomandibular joint disorders. PubMed, Europe PM...

Pediatric Metabolic Syndrome Through the Lens of Cardiovascular-Kidney-Metabolic Syndrome: A Scoping Review of Definitions, Epidemiology, Outcomes, and Conceptual Implications for Children and Adolescents

Abstract Purpose of Review The pediatric metabolic syndrome (MetS) construct lacks an accepted definition, with frameworks yielding prevalence estimates that vary by an order of magnitude within the same populations. In 2023, the American Heart Association introduced cardiovascul...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...