Macau University of Science and Technology

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Pharmacological inhibition of Alistipes putredinis-derived indole-3-acetic acid by baicalin suppresses stress-driven breast cancer metastasis

Breast cancer patients often experience chronic stress disorders and gut dysbiosis. Baicalin has been demonstrated to have antitumor, antibacterial and microbiota regulatory functions and can be used for treating breast cancer and preventing metastasis; however, how baicalin regu...

Safety Paradox: How Uncertainty Shapes Immersive Engagement and Social Bonding in Location-Based Virtual Reality

Location-based virtual reality (VR) enables large-area movement and co-located interaction in immersive shared environments. However, little is known about how users experience and regulate safety in hybrid physical–virtual spaces, particularly under uncertainty and social coordi...

Flexible Photochromic Synaptic Devices for UV Perception and Spatiotemporal Encoding

ABSTRACT Flexible synaptic devices with short‐term optical dynamics offer promising building blocks for low‐power and visualized neuromorphic perception, yet introducing time‐dependent weight update and visual readout remains highly challenging. Herein, we establish a universal s...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

ABSTRACT Excellent electromechanical properties of piezoceramic thin films facilitate ultrasonic energy harvesting in bioelectronic systems. However, most piezoceramic thin films are fragile and cannot maintain mechanical integrity under deformation, hindering their application i...

Carbon dots in photocatalytic water splitting and related proton/electron‐coupled reactions: Multiscale regulation of charge dynamics and interfacial processes

Abstract Photocatalytic water splitting provides a representative platform for understanding the relationship between photogenerated charge utilization and interfacial catalytic conversion. The overall efficiency of this process is governed by the coupling between ultrafast photo...

Results reporting and primary endpoint achievement in interventional therapeutic trials for pleural mesothelioma, 2005–2025: a cross-sectional analysis

Pleural mesothelioma (PM) is a rare and aggressive malignancy in which therapeutic progress depends on a limited clinical trial evidence base. Although trial registration has improved transparency, the extent to which registered trials generate publicly available and clinically i...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

An investigation on TPB–NAM-based factors of the application of circular packaging

Abstract Faced with the pressure of packaging waste caused by e-commerce growth, Circular Packaging, as a sustainable logistics model that achieves multiple closed-loop circulations of packaging supported by standardized design and intelligent systems, is a crucial pathway for im...

MSDR-Mamba: A Multi-Scale Branch-Decoupled Routing State-Space Detector for Temporal Action Localization

Temporal action localization (TAL) requires a detector to recognize action categories and estimate temporal boundaries in untrimmed videos. Mamba supports linear-complexity long-sequence modeling, yet a uniform allocation of state-space operators does not explicitly differentiate...

Interpretable machine learning models for analyzing predictors of first-aid knowledge among older adults in Chinese communities: a cross-sectional survey study

This study aimed to investigate the current status of first aid knowledge and its associated factors among community-dwelling older adults using machine learning (ML) models. This cross-sectional study recruited community-dwelling older adults aged 60 years and above. Face-to-fac...

Beyond Economic Benefit: How Justice, Empowerment, and Political Trust Shape Residents’ Support for Space Tourism

This study extends research explaining resident trust through cost–benefit evaluations of tourism development. In the context of space tourism development, a government-led initiative that offers residents limited participation and few direct benefits, we drew on Lefebvre’s right...

Revisiting feeling rules: how emotional labour fosters emotional capital among hospitality and tourism interns in Macao

While emotional labour is well-established in hospitality research, existing scholarship predominantly focuses on established employees, largely overlooking how organisational novices navigate professional socialisation. Specifically, how liminal cohorts like interns manipulate o...

Mechanistic Originsof Enhanced PET Hydrolase Activityfrom Molecular Dynamics and Deep Learning-Assisted Network Analysis

Abstract Polyethylene terephthalate (PET) hydrolase-based biodegradation offers a promising route for plastic waste remediation, yet the dynamic origins of high activity and their linkage across catalytic stages still require further elucidation. Here, we focus on the Leaf-Branch...

Encapsulated CsPbBr3 quantum dots with asymmetric chiral magneto-optoelectronic responses

Quantum emitters having non-trivial spin polarizations are highly demanded for chiral quantum devices and quantum photonic technologies. Here we investigate the magneto photoluminescence spectroscopy of perovskite quantum dots encapsulated in silica and report an observation of c...

The efficacy of stem cell therapy: cells or their microenvironment?

The therapeutic outcomes of stem cell therapy are determined not solely by cellular potency alone, but also by the receptiveness of the host microenvironment. Despite continuous progress in stem cell quality control and functional optimization technologies, inconsistent outcomes...

Spatiotemporal prediction of two-dimensional surface deformation in gas field incorporating MSBAS-InSAR and deep learning

Continuous extraction-induced deformation from oil and gas fields can trigger destructive geological hazards, significantly threatening underground infrastructure safety. Therefore, reliable surface deformation prediction is crucial for early warning of potential risks in oil and...

Tensile Behaviors of Textile Grid–Reinforced One-Part Engineered Geopolymer Composites

Abstract This study developed and characterized textile grid–reinforced one-part engineered geopolymer composites (TR-OPEGCs) via experimental tests (including flow table, compression, direct tension, and textile-reinforced tensile tests) and numerical approaches, focusing on the...