Lund University

Potential sublimating exocomets around the young star PDS 70

Abstract Recent observations by the James Webb Space Telescope (JWST) have indicated the presence of water in the inner regions of the disc around the young protostar PDS 70, but the origin of this water remains unclear. Here we report the discovery of variable absorption lines o...

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial c...

Increasing peak load gas turbine fuel efficiency by utilizing its waste heat in the preheater chain of a district heating power plant

There has been an increased interest in utilizing gas turbine facilities with batteries due to continued increase in intermittent energy source production. Gas turbine-battery combination is able to cover the different categories of frequency containment reserve. One issue with o...

Single-photon double ionization of ozone: experiment and theory

Abstract The triatomic molecule ozone (O3) is of outmost physical and chemical importance in the atmospheres of our Earth and other planets. Beyond its environmental significance, a detailed understanding of the electronic structure and ionization dynamics of ozone is essential f...

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...

Clinicians’ practices and attitudes toward depression assessment: a cross-sectional survey study

<title>Abstract</title> Accurate psychological evaluation is crucial for early detection, intervention and evaluation of mental health disorders. The validity and reliability of psychological evaluation methods have been systematically researched for many decades. However, assess...

Establishing a baseline for energy-efficient climate adaptations in a typical Swedish pig facility

A facility for growing fattening pigs was investigated for building properties, energy use, and indoor climate in a cold-climate region to establish a baseline that supports future energy-efficient climate adaptation in pig buildings. The building under study was insulated and us...

Overcoming Uncontrolled Nucleation and Cesium Salt Solubility Limits in Scalable Perovskite Deposition through All-Inorganic Perovskite Nanocrystal Seeding

Abstract Optoelectronic performance, defect density, and thin-film morphology of solution-processable lead halide perovskites are highly dependent on nucleation and growth conditions during processing. Additionally, Cs+ incorporation into the lattice can have benign effects on th...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born &lt;27‐gestation wee...

Donor‐induced conformational gating and substrate‐assisted catalysis in α ‐1,3‐galactosyltransferase

Retaining glycosyltransferases catalyze the formation of stereochemically conserved glycosidic bonds through mechanisms that remain debated. Using bovine α1,3-galactosyltransferase (α3GalT) as a model, we combine mutagenesis, equilibrium unfolding, kinetics, and molecular dynamic...

Structural and Biophysical Characterization of C‐Glycosylic 1,2‐Thiodisaccharides Reveals Determinants of Selective Binding to Galectin‐7 and Galectin‐8N

Achieving isoform selectivity within the galectin family remains a central challenge in glycomimetic drug design due to the highly conserved architecture of their carbohydrate recognition domains. Here, we define the structural and thermodynamic basis of recognition of a series o...

Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol

Abstract Enzyme engineering has produced numerous methods to optimize enzymes for biotechnological processes; however, less is known about how natural evolution creates new functionalities. We investigate the evolutionary emergence of enantioselectivity in plant borneol dehydroge...

Precision monitoring of leaf area index and chlorophyll content of major field crops in Northern Europe using UAV remote sensing and radiative transfer modeling

Abstract Purpose Long-term monitoring of crop biophysical and biochemical traits remains challenging in high-latitude regions due to short growing seasons, frequent cloud cover, and highly variable weather. In this context, unmanned aerial vehicles (UAVs) offer flexible, high-res...

Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study

Abstract Background Sepsis is a major public health challenge, and reliable biomarkers are essential for distinguishing sepsis from other conditions. Neutrophil Gelatinase-Associated Lipocalin (Neutrophil gelatinase-associated lipocalin (NGAL)) has shown promise as a diagnostic m...

Translational insights and clinical challenges of targeting cancer stem cells

Abstract Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durab...

Genomic analysis and clinical characteristics of a seasonal upsurge of Streptococcus pyogenes emm12

Abstract Purpose Streptococcus pyogenes cause invasive infections with variable incidence over time. In 2023, an increase in invasive S. pyogenes infections caused by emm- types 1 and 12 was reported globally. In Southern Sweden an increase in S. pyogenes emm 12 severe infections...

Direct Detection of Hydrogen Reveals a New Macroscopic Crustal Water Reservoir on Early Mars

Abstract The next great leap in Martian exploration is the return of samples to Earth. Maximizing their scientific value requires non‐destructive analytical techniques for early three‐dimensional characterization. Neutron computed tomography (CT), highly sensitive to hydrogen, co...

Deep generative model for human mobility behavior

Understanding and modeling human mobility is central to challenges in transport planning, sustainable urban design, and public health. Despite decades of effort, simulating individual mobility remains challenging because of its complex, context-dependent, and exploratory nature....

The geography of power and transition work: insights from the bio-based construction sector in South Westfalia, Germany

This paper examines how power relations of actors shape (socio-technical) transition processes. While transition studies increasingly emphasize the relevance of agency for change, the role of power remains insufficiently understood, particularly at the micro level and in regional...

Element-Specific DonorNumbers for Anions

Abstract Anion interactions with cations/molecules are crucial across chemistry and biology: in battery electrolytes, synthesis, atmospheric processes, and protein denaturation. Selecting the optimum anion represents an immense challenge, as anion interactions are diverse and com...