Lund University

Structural and functional insights into a Zn2+-transporting P-type ATPase

Abstract Zinc is essential for life yet toxic in excess, rendering homeostatic control vital for all organisms. Transition metal transporting P-type (P IB -) ATPase proteins are critical for this balance but remain poorly understood at the molecular level. Here, we present the in...

Study of Supernova Neutrinos at ESSnuSB

In this paper, we have studied the sensitivity of the ESSnuSB far detector to supernova neutrinos. ESSnuSB is a proposed long-baseline neutrino experiment in Sweden, which will use a 538 kt water Cherenkov detector to probe the leptonic phase δCP by studying the second oscillatio...

Cardiovascular Effects of Chronic GIPR and GLP-1R Agonism in Lean and Diet-Induced Obese Mice: Sex Differences and Dose-Dependent Remodeling

Glucose‑dependent insulinotropic polypeptide (GIP) and glucagon‑like peptide‑1 (GLP‑1) regulate metabolism and are increasingly targeted in therapies for type 2 diabetes and obesity. Although GLP‑1 receptor agonists confer cardiovascular benefits, the cardiovascular effects of GI...

Local context and marriage choices: the role of neighbourhood status in early 20th-century southern Sweden

This study examines the role of neighbourhood status in partner selection during the early and mid-20th century, a period of rapid industrialization and social change. While contemporary research emphasizes achieved characteristics such as education, historical marriage patterns...

Targeting C4d to overcome resistance to antibody-based immunotherapy: an in vitro study

Tumor cells often develop defense mechanisms that render them insensitive to consecutive administrations of therapeutic monoclonal antibodies. This study aimed to produce an antibody that preferentially binds resistant tumor cells and eliminates them by the complement system atta...

The affective paradox in populist online communities: Emotional capital and emotional liability

Various studies demonstrate that emotions may both facilitate and complicate political mobilization. We study the role of emotions for supporters of populist, largely far-right, online movements. Using life history interviews, we show how 20 Twitter users in the United States and...

36Cl concentrations from polar ice cores set new constraints on the Carrington event.

The Carrington event of 1859 CE is considered one of the largest geomagnetic storms of the observational era and often used as a benchmark for a worst-case scenario. Yet, there exists no robust evidence of an associated solar energetic particle (SEP) event of a significant magnit...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Radiation doses during extreme solar energetic particle events

Ions and electrons accelerated to high energies during flares and coronal mass ejections at the Sun may escape the solar atmosphere and, guided by the interplanetary magnetic fields, propagate through space to near-Earth locations. These Solar Energetic Particles (SEPs) can be de...

Optimisation of an Algorithm for Fetal Strain by CMR and its Use in Suspected Coarctation of the Aorta

Abstract Prenatal diagnosis of coarctation of the aorta (CoA) remains challenging, with low detection rates and high false positive rates. It is unknown whether fetuses that develop postnatal CoA (true CoA) exhibit impaired ventricular strain prenatally or whether fetal cardiac m...

Disease-activity-linked complement-coagulation interactions and persistent platelet activation in treatment-naïve systemic lupus erythematosus

Background Thrombosis is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although multiple prothrombotic pathways have been identified, most have been studied individually or after treatment initiation. We aimed to characterize interactions between...

Biocatalytic upgrading of fusel oil from bioethanol production to levulinate esters as renewable fuel oxygenates

Abstract Background The transition toward a sustainable bioeconomy requires efficient strategies for converting renewable biomass and industrial side streams into value-added chemicals and fuels. Fusel oil is an important coproduct of bioethanol fermentation and levulinic acid (L...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

TIS subsystems and modes of innovation: the case of hydrogen-powered aviation

Recent technological advancements in hydrogen-powered aviation are significantly influenced by start-up companies, despite substantial market entry barriers. To investigate the role of these emerging actors in the sustainability transition of the aviation sector, we compare the i...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

The kallikrein-kinin system modulates CD4+ T cell function and contributes to T cell migration into the brain after stroke

Abstract Ischemic stroke elicits a sustained thromboinflammatory response that critically shapes secondary brain injury. The kallikrein-kinin system (KKS) has been identified as the interface of vascular injury and inflammatory processes; however, its role in adaptive immunity re...

Childhood inductive reasoning, cardiovascular and cardiometabolic morbidity and dementia risk – a population representative cohort study across six decades

Abstract Background Higher cognitive ability in late adolescence and young adulthood associate with reduced risk of dementia, but such assessments are influenced by educational selection. Whether specific cognitive abilities earlier in childhood associate with later dementia risk...

From multi-source data uncertainty to interval-based robust calibration: A transferable solution for hydrological modeling in data-scarce alpine basins

Study Region The European Alps feature steep elevation gradients, snow-influenced hydrology, and strong spatial variability in water and energy fluxes. Hydrological modeling is limited by sparse high-elevation observations, while growing multi-source data availability introduces...

Dopamine D2/3 receptors and functional connectivity during fear extinction: A PET-fMRI study

Background The ability to learn what is dangerous in the environment and what no longer exerts a threat is essential for survival. The latter process is studied using Pavlovian fear extinction, the repeated presentation of a feared stimulus that gradually attenuates the fear resp...

FOR-HEALTH: study protocol for a randomized controlled feasibility trial of Structured Health Dialogues to improve lifestyle habits and metabolic health in forensic psychiatric inpatients

Abstract Background People with severe mental illness demonstrate markedly reduced life expectancy, largely due to preventable cardiometabolic disease. This burden is particularly pronounced in compulsory forensic psychiatric care, where prolonged inpatient stays, restrictive env...