LMU Klinikum

Assessment of the effectiveness of protein in critical illness: the role of statistical shortcomings in explaining discrepancies between observational studies and randomized controlled trials

Until 2023, recommendations for prescribing protein to critically ill patients were largely based on observational studies and non-randomized interventions. Several large, multicentre non-randomized studies of intervention conducted between 2009 and 2017 consistently reported tha...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Maribavir in lung transplant recipients with cytomegalovirus infection: real-life experience

Abstract Introduction Cytomegalovirus remains a major challenge in LTx recipients. Despite advances in antiviral therapy, refractory and resistant CMV infections persist, and real-world data on maribavir, a recently approved UL97 kinase inhibitor, are limited. Methods We retrospe...

Tracking funding disparities in global health aid with machine learning

Abstract Reducing the global burden of disease is crucial for improving health outcomes. However, misalignment between health aid and country-level disease burden leaves vulnerable populations without the necessary support for major health challenges, particularly in the least de...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5

BACKGROUND: Primary aldosteronism is frequently caused by mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding a G-protein inwardly rectifying potassium channel. These mutations disrupt the channel’s selectivity filter, permitting abn...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

CODAC: Constraint-based Deep Active Clustering

Abstract Constraint-based Deep Active Clustering (CODAC) integrates actively selected pairwise constraints into deep representation learning to efficiently improve existing cluster structures, even under tight query budgets. CODAC encodes the constraint information into the embed...

Conservative and surgical treatment of wrist osteoarthritis: a systematic review

INTRODUCTION: Wrist osteoarthritis leads to pain and functional impairment. Despite conservative treatment options, surgery remains a central therapeutic component. In Germany, the number of patients rose from over 472,000 cases in 2018 to more than 580,000 in 2024. This review e...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Impact of structured reporting on interpretability of PSMA PET/CT in prostate cancer staging—towards standardised clinical implementation

OBJECTIVE: This study assessed the impact of structured reporting (SR) compared with conventional free-text reporting (FTR) on report quality for PSMA PET/CT for diagnosis and staging of prostate cancer (PC) using a dedicated template. MATERIALS AND METHODS: Fifty consecutive pat...

Combination of antibody-based screening methods for the identification and quantification of Legionella pneumophila in process water

Legionnaires’ disease is a severe and often fatal pneumonia primarily caused by the inhalation of aerosols contaminated with the waterborne pathogen Legionella pneumophila serogroup 1. While conventional culture-based detection is often standard for monitoring evaporative cooling...

What constitutes successful collaborative conjecturing-and-proving processes? Relations between beginning undergraduates’ resources, conjecturing-and-proving processes, and performance

Abstract Students’ difficulties with mathematical argumentation, conjecturing, and proving, as well as with collaborating effectively, have long been documented in the literature. While there is some research on what constitutes successful proving processes, systematic investigat...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

Artificial Intelligence in Orthodontics: Part 2—Data Preparation and Performance Evaluation

Artificial intelligence (AI) is increasingly integrated into orthodontic research and clinical workflows. Yet, the reliability and clinical value of these systems depend fundamentally on the quality of the data used to train them and the rigour with which their performance is eva...

Reproducible analysis and structured dataset for "Toward clinical-grade deep learning in coronary angiography: a systematic review"

This record contains the structured dataset and analysis code accompanying the systematic review "Toward clinical-grade deep learning in coronary angiography". The dataset comprises extracted study characteristics and quality appraisal results for the included studies, together w...

Investigating changes in the blood-brain barrier in schizophrenia spectrum disorders: design and methodology of a longitudinal dynamic contrast-enhanced MRI study

Schizophrenia spectrum disorders (SSDs) are clinically and biologically heterogeneous and lack reliable biomarkers for stratification, treatment response and course prediction. Evidence from postmortem, fluid biomarker, and neuroimaging studies suggests that changes in the blood-...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Polymer Substrates for Flexible Sensors: Advances and Contributions to Smart Agriculture

ABSTRACT The advancement of smart agriculture is becoming increasingly dependent on sensor technologies that enable the digitization and optimization of agricultural processes. Traditional sensors, however, are constrained by their inherent rigidity, poor conformability to irregu...

Primary splenic Alveolar Echinococcosis: a case report from Germany

PURPOSE: We are reporting on a rare case of a primary manifestation of Alveolar Echinococcosis in the spleen in a German patient. METHODS: The patient was initially presented to her gastroenterologist and subsequently referred to a district hospital for surgical management. The f...