King Khalid University

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Enhanced Control of 1.5 MW DFIG Generators in MRWT Systems Using GA‐Based PI‐ST‐SMC: Comparative Assessment With ST‐SMC

ABSTRACT This paper proposes a novel genetic algorithm‐based proportional–integral super‐twisting sliding mode control (GA‐PI‐ST‐SMC) strategy for the rotor‐side converter of a 1.5 MW doubly‐fed induction generator (DFIG) operating in marine renewable wind turbine (MRWT) systems....

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Effectiveness of gabapentinoids for postoperative pain management and opioid reduction after lumbar spine surgery: a systematic review and meta-analysis

Background Lumbar spine surgery is commonly associated with moderate to severe postoperative pain, often requiring opioid analgesics. Gabapentinoids are widely incorporated into multimodal analgesic regimens; however, their effectiveness in this setting remains uncertain. Methods...

Prevalence of Delayed Healthcare Presentation and Associated Factors in Patients with Predominantly Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Background/Objectives: Traumatic brain injury (TBI) is a global burden and a leading cause of death and disability worldwide. Delayed healthcare presentation is significantly associated with poor outcomes. This systematic review and meta-analysis aim to estimate the prevalence of...

Nocturnal Surface Urban Heat Island Dynamics in a Semi-Arid Mediterranean City: Evidence from Damascus

Although nocturnal surface urban heat islands, which impede physiological recovery during rest, have been characterized in many cities worldwide, Syria’s capital, Damascus, situated in the Eastern Mediterranean region, remains without a quantitative, multi-time assessment of its...

A COMPARISON BETWEEN A PROPOSED MULTIPLICATION FORMULA AND TRADITIONAL ALGORITHMS FOR TEACHING MULTIPLICATION IN ELEMENTARY SCHOOLS

This paper describes a place-value procedure for multiplying non-negative integers. Each number is split into its units digit and the block of digits to its left. The calculation then uses three parts: the product of the units digits, the sum of the two cross-products, and the pr...

Binclean: Sanitizing Disassemblies to Improve Malware Recognition

Malware is malicious software that compromises data and computer systems. In 2024, the Internet Crime Complaint Center (IC3) reported $12.47 million in ransomware losses alone, highlighting the escalating severity of cyber threats. Because source code is rarely available, analyst...

Enterprise size economic activity and regional factors as determinants of SME growth in Saudi Arabia

The paper examines the determinants of the success of small and medium-sized enterprises (SMEs) in Saudi Arabia with respect to the interaction between enterprise size, type of economic activity, and regional factors. We test a theoretical framework based on the resource-based vi...

Thermoelectric ultra-high-performance geopolymer concrete containing nano carbon black: synergistic enhancement of mechanical, transport, and energy-harvesting performance

Ultra-high-performance geopolymer concrete (UHPGC) offers a sustainable alternative to conventional cement-based materials by combining lower carbon emissions with superior mechanical performance; however, its thermoelectric potential remains largely unexplored. This study evalua...

Early versus delayed IV-to-oral antibiotic transition: clinical deterioration after oral switch and variation across regimen pathways

Objective This retrospective cohort study aims to assess associations of delayed Intravenous (IV)-to-Oral switch after 72-hours versus early switch within 72-hours with switch failure within 7-days and with adjusted post switch clinical outcomes in hospitalized adults.Methods Adu...

Shear bond strength of ceramic orthodontic brackets to bulk-fill, packable, and flowable composite restorations under different thermal aging protocol of the substrate: an in vitro study

Long term success of orthodontic treatment depends on the bond strength of orthodontic brackets with tooth and/or restorative materials. This in vitro investigation aimed to assess and compare the shear bond strength (SBS) of ceramic orthodontic brackets bonded to bulk-fill, pack...

Investigating the hydrogen storage potential and optoelectronic properties of double perovskite ZMg2FeH8 (Z = Ca, Be) hydrides

Abstract Hydrogen presents a compelling solution to the growing energy scarcity and environmental problems as a clean and sustainable energy source. Among various storage methods, solid-state hydrogen storage holds promise but necessitates extensive investigation. However, to enh...

Global Dynamics and Complete Phase Portrait Classification of a Nonlinear SIRS Model with Saturated Incidence

This paper investigates the global dynamics of a nonlinear Susceptible–Infective–Recovered–Susceptible (SIRS) epidemic model with a nonmonotonic saturated incidence rate. By reducing the model to a planar cubic polynomial differential system, we perform a complete qualitative ana...

AI ‐Enabled 6G Space‐Air‐Ground–Integrated Networks for Ultra‐Reliable Low Latency Internet of Medical Things Healthcare

ABSTRACT This paper explores an AI‐assisted resource scheduling and cooperative learning model in a space–air–ground combined network (SAGIN) to possess ultra‐reliable low‐latency Internet of Medical Things (IoMT) applications. The generated healthcare data by the IoMT devices ar...

DFT supported experimental evaluation of air oxidation converting a thiosemicarbazone oxidovanadium(IV) to a dioxidovanadium(V) complex

Two novel vanadium complexes, viz., an oxidovanadium(IV) complex [VO(HL)(acac)] (1) and a dioxidovanadium(V) complex [VO₂(HL)(H₂O)] (2), were synthesized using the tridentate ONS-donor Schiff base ligand H₂L (N-(dehydroacetic acid)-4-phenyl-3-thiosemicarbazone). The complexes wer...

Eugenol extraction and characterization from clove as a potential anticancer therapeutic agent against breast cancer: Combining an in vitro and in silico molecular docking and dynamics studies

Breast cancer (BC) is leading cause of cancer-related mortality among women worldwide, with approximately 2.3 million new cases and 670,000 deaths reported in 2022. Despite advances in therapy, challenges such as drug resistance and adverse side effects necessitate the exploratio...

Comparative evaluation of the effect of whey protein powder and plant-based protein powder on the microhardness, sorption, and solubility of a nano-hybrid giomer restorative composite: an in vitro study

Whey and plant protein powders are becoming common additions of people concerned with fitness in their diet. Consumed repeatedly as reconstituted shakes, these products remain in contact with the dentition for extended periods and introduce a chemically heterogeneous mixture of o...

Recent Advances of Metal–Organic Frameworks‐Based Sensors for Food Safety and Environmental Monitoring

Metal‐organic frameworks (MOFs) are versatile porous materials increasingly used in sensing for food safety and environmental monitoring, where on‐site detection is critical. Compared to traditional methods, MOF‐based sensors offer higher surface areas, tunable pores, abundant ac...

Application of in vitro digestion and dialysability procedure for bioavailability evaluation of toxic elements in green leafy vegetables: a realistic health risk assessment by Monte Carlo simulation

Green leafy vegetables (GLVs), which are vital and widely consumed worldwide, require monitoring for contaminants, including toxic elements (TEs). This study measured total concentrations (TC) and bioavailable concentrations (BC) of arsenic (As), cadmium (Cd), lead (Pb), chromium...