Keio University

Lateralization of retinal structure correlated with behavioral lateralization in the oval squid Sepioteuthis lessoniana

Abstract Background Cephalopods, including Sepioteuthis lessoniana , preferentially orient either the left or right eye toward visual targets during various visually guided behaviors, as most of their visual field is monocular. Such visual lateralization is widely observed in the...

Local anesthetic lidocaine decelerates cytoplasmic streaming in Egeria densa via altered actin dynamics and reactive oxygen species generation

Local anesthetics (LAs) block voltage-gated Na+ channels in mammals, but they also affect cytoplasmic streaming in plant cells. Although certain LAs inhibit streaming in algae such as Chara, the underlying mechanisms remain unclear. This study aimed to elucidate how LAs reduce cy...

Predicting facial impressions using guided Grad-CAM and a large language model

Facial impressions are central to social interaction, shaping judgments of attractiveness, dominance, and trustworthiness. Although psychophysical research has identified factors that contribute to these impressions, computational methods, particularly deep learning, offer a comp...

A Digitally Controlled Flow–Batch Platform for Reproducible Radical Copolymerization with Reduced Composition Drift

Abstract Free-radical copolymerization is widely used industrially, but scale transfer can alter polymer properties through changes in mixing and heat transfer. We developed a digitally controlled flow–batch platform integrating a micromixer, heated tubular reactor, and batch rea...

Systemic administration of the mGluR2/3 antagonist LY341495 disrupts reward-related behaviors across ingestive and social domains in mice

Metabotropic glutamate 2/3 receptors (mGluR2/3) have been implicated in depression, anxiety, learning, and memory, yet their role in reward-related behavior remains poorly understood. Here, we examined the effects of the selective mGluR2/3 antagonist LY341495 on reward-related be...

Simultaneous Network Design With Restricted Link Usage

ABSTRACT Given a digraph with two terminal vertices and as well as a conservative cost function and several not necessarily disjoint color classes on its arc set, our goal is to find a minimum‐cost subset of the arcs such that its intersection with each color class contains an ‐...

Prognosis and risk factors by histologic type of malignant ovarian germ cell tumors in Japan: a JSOG gynecologic tumor registry-based study

Objective: This study evaluated prognosis and risk factors for overall survival (OS) in malignant ovarian germ cell tumors (MOGCTs) using data from the Japan Society of Obstetrics and Gynecology tumor registry.Methods: Data from 1,538 MOGCT patients (2004MOGCT patients ( -2019) )...

Progressive micrographia in Parkinson’s disease is associated with multidimensional cognitive and motor features

Abstract Progressive micrographia, characterized by a gradual reduction in handwriting size, is a common yet incompletely understood feature of Parkinson’s disease (PD). It has been associated with both motor and cognitive impairment; however, the clinical characteristics associa...

Guideline impact on antibiotic use for tooth extraction across facility types in Japan: an interrupted time series analysis using a health insurance claims database

Objective The objective of this study was to evaluate the impact of dental antibiotic guidelines recommending amoxicillin (AMPC) over third-generation cephalosporins (3GCs) for prophylactic use on surgical site infections (SSI), prescription patterns, and cost-effectiveness acros...

Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization

Abstract Synapses, prototypic sites for neuronal communication, are key to brain function. Their organization and properties are instructed by synaptic cell adhesion molecules (sCAMs) that may operate independently or in coordination through yet unknown linker proteins. Here, we...

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Study DesignRetrospective analysis of a prospectively maintained multicenter cohort.ObjectivesTo identify clinical characteristics associated with clinically meaningful improvement in neuropathic pain and to evaluate its relationship with postoperative functional outcomes in pati...

ASEAN's Regional Growth Account: Accumulation-Led Growth, Intermittent Productivity Gains

Productivity Research Notes (PRN Series), No. 2620 This note constructs a regional growth account for the ten ASEAN member economies as of 2024, covering 1970–2024. Real output grew by an average of 5.3% per year, with capital contributing 3.1 percentage points, labor 1.6 points,...

MIBO Core Protocol Package v2.0

MIBO Core Protocol Package v2.0 prospectively defines a fully automated, provider-API observation design for MIBO Core. The primary API Core Interface (ACI) condition follows the four registered MIBO service lineages with the unchanged 24 Japanese/English Query Forms and ten inde...

Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression

ABSTRACT Objective Stanford Neuromodulation Therapy (SNT) has demonstrated impressive efficacy for treatment-resistant depression (TRD), but its neurophysiological mechanisms remain poorly understood. This study investigated the neurophysiological correlates of SNT using transcra...

Development of Hamiltonian for Structural Applications by Quantum Annealing Assuming Finite Element Method

ABSTRACT Quantum annealing is emerging as a practical tool for large‐scale combinatorial optimization. We map continuum displacements and element densities to binary variables, turning both deformation analysis and topology optimization into quadratic unconstrained binary optimiz...

24-hour movement behaviour patterns differ across depressive symptom trajectories in community-dwelling older adults: a group-based trajectory model and compositional data analysis

Depressive symptoms in older adults change over time and do not follow a single uniform pattern. Whether 24-hour movement behaviour composition differs across depressive symptom trajectories remains unclear. This longitudinal secondary analysis used data from the Survey of Health...

Get With The Guidelines–Heart Failure Hospital Participation and Its Association With Guideline-Directed Medical Therapy and Outcomes

Abstract Purpose Despite strong evidence, real-world adoption of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains suboptimal. The Get With The Guidelines–Heart Failure (GWTG-HF) program was designed to close gaps in care....

Evaluating the Solution Performance of the Augmented Lagrangian Function on Ising Machines

We apply the augmented Lagrangian function (ALF) as a formulation for Ising machines and evaluate its performance by time-to-epsilon (TTε). The ALF has been well studied in continuous optimization for its numerical stability and convergence, and its advantage over the penalty fun...

Minimal organism JCVI-syn3.0, an engineered derivative of Mycoplasma mycoides , encodes an assortment of unrecognized membrane transporters and immunity factors

ABSTRACT In 2016, researchers at the J. Craig Venter Institute produced JCVI-Syn3.0, a derivative of Mycoplasma mycoides subsp. capri Large Colony strain GM12 with a re-engineered, minimized genome. The minimal synthetic genome of 532 kbp encodes 473 genes, selected from ∼910 par...

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...