Keio University

MIBO-Education Protocol Package v1.0

MIBO-Education Protocol Package v1.0 provides the frozen scientific specification for MIBO-Education, a longitudinal observatory of educational behavior in general-purpose generative-AI services and an official Satellite of the Machine Information Behavioral Observatory (MIBO). T...

OA03-RF01.08. Clinical Significance of Circulating Tumor DNA Dynamics in Patients With Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background In the perioperative management of esophageal squamous cell carcinoma (ESCC), the accuracy of conventional modalities such as computed tomography and esophagogastroduodenos...

MIBO-Education Protocol Package v1.0

MIBO-Education Protocol Package v1.0 provides the frozen scientific specification for MIBO-Education, a longitudinal observatory of educational behavior in general-purpose generative-AI services and an official Satellite of the Machine Information Behavioral Observatory (MIBO). T...

Half the Capital Stock, One Premise: Japan's ¥1 Quadrillion of Implicit Power-System Credit

Productivity Research Notes (PRN Series), No. 2619 Reliable electricity at economically viable prices underpins long-lived capital. Using a bottom-up classification of more than 170 asset categories, this note estimates Japan's electricity-dependent capital stock at ¥1,000.8 tril...

Half the Capital Stock, One Premise: Japan's ¥1 Quadrillion of Implicit Power-System Credit

Productivity Research Notes (PRN Series), No. 2619 Reliable electricity at economically viable prices underpins long-lived capital. Using a bottom-up classification of more than 170 asset categories, this note estimates Japan's electricity-dependent capital stock at ¥1,000.8 tril...

Cryo-EM structure of the bicarbonate receptor GPR30

G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive. There is no consensus on...

Experimental Development of Gaseous Propellant Mono-Cylindrical Rotating Detonation Engine Film Cooling

Thermal management remains one of the critical challenges in the advancement of rotating detonation engine (RDE) technology for practical propulsion applications. To facilitate progress in this field, this study investigates the use of gaseous film cooling via axial injectors, ai...

Des‐Gamma‐Carboxy Prothrombin Is Associated With Tumor Aggressiveness and Recurrence in Resected Early‐Stage Hepatocellular Carcinoma: A Clinicopathological and Molecular Analysis

ABSTRACT Aim Alpha‐fetoprotein (AFP) and des‐gamma‐carboxy prothrombin (DCP) are widely used tumor markers for hepatocellular carcinoma (HCC); however, their relative prognostic significance in early‐stage disease remains unclear. This study aimed to compare the prognostic impact...

Trajectory elevation in reach-to-grasp movements under increased arm weight and repeated trials

This study examined how three-dimensional upper-limb movement trajectories are modulated by changes in gravitational load. We hypothesized that individuals adopt a trajectory elevation strategy in reach-to-grasp movements performed on a desk to compensate for increased movement v...

ActivAsk: Free-Energy-Guided Clarification for Robotic Grasping Under Ambiguous Instructions

Service robots often receive natural language instructions in changing workspaces where multiple visible objects may match one description. Relying on detector confidence, random selection, or direct vision–language model (VLM) prediction can lead to a wrong action. This paper pr...

Fast robust additive models using gamma-divergence

Abstract Additive models offer a flexible framework for modeling nonlinear relationships between predictors and a continuous response variable, where nonparametric terms are commonly modeled via penalized splines. However, such models can be sensitive to outliers, leading to pote...

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

A Survey of Community Pharmacists’ Perceptions and Issues Regarding the Indiscriminate Long-Term Use of Proton Pump Inhibitors

Proton pump inhibitors (PPIs) are classified as potentially inappropriate medications for older adults. Indiscriminate long-term use of PPIs after symptom resolution (indiscriminate PPIs) may increase the risk of adverse events and healthcare costs, emphasizing the need for appro...

BRAF/MEK Inhibitor Therapy for Recurrent Papillary Thyroid Carcinoma Encasing the Common Carotid Artery

従来，根治切除不能なRAI不応再発転移分化型甲状腺癌に対して使用されてきた多標的チロシンキナーゼ阻害薬のレンバチニブは，出血リスクから大血管浸潤が疑われる例では使用回避が望まれるが，BRAF/MEK阻害薬は明確な禁忌は示されていない。今回われわれは，総頸動脈を全周性に取り囲む甲状腺乳頭癌再...

Analysis of Pharmacist Interventions during Remote Accompaniment to Physician’s Home Visits in a Medically Underserved Area: A Comparative Study with Conventional In-Person Practice

Participation of pharmacists during physicians’ home visits is effective in home healthcare. However, substantial practical barriers exist in regions where medical resources are unevenly distributed. This study sought to clarify the effectiveness and limitations of a hybrid onlin...

Attention‐Based Spatial–Temporal Model for the Entire Indoor Space Temperature Estimation

This study proposes a novel attention‐based spatial–temporal model for indoor temperature estimation, which integrates positional encoding and an attention mechanism with a fully connected neural network. By jointly capturing temporal dynamics and spatial correlations, the model...

Patient acceptance of regenerative medicine trial designs for spinal cord injury in a nationwide web-based survey in Japan

Abstract Patient acceptance of regenerative medicine trial designs in spinal cord injury (SCI) remains poorly understood. We conducted a nationwide, anonymous, web-based survey of individuals with SCI in Japan to assess willingness to participate in hypothetical regenerative medi...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...

Cross-disease immunological comparison reveals shared systemic immune activation across the broader spondyloarthritis spectrum

To perform cross-disease immunological comparison across the broader spondyloarthritis (SpA) spectrum and examine their association with disease activity. We analyzed 111 patients with active broader SpA spectrum (ankylosing spondylitis, inflammatory bowel disease–associated SpA,...

Genomic resources of Ascidiella aspersa and comparative analysis across tunicates reveal class-level features and evolutionary diversification

Ascidiella aspersa is an invasive tunicate and one of the closest relatives of vertebrates. Despite its ecological nuisance, A. aspersa is anticipated to be a valuable model organism for developmental studies due to its remarkably transparent embryos. However, annotated genome as...