Johnson University

Substance use diagnoses among patients who present to federally run mental health facilities with co-morbid ADHD and bipolar disorder between 2013-2023: a national analysis using random forest methods

Background/Objectives Although substance use disorder is common in patients with attention deficit hyperactivity disorder or bipolar disorder, limited recent data exist for those with these co-occurring conditions. Our study analyzes recent trends and predictors of these diagnose...

Toxin-mediated tRNATrp depletion drives Trp-codon-dependent reprogramming in Mycobacterium tuberculosis while selectively enriching the PDIM biosynthetic machinery

Mycobacterium tuberculosis (Mtb) must adapt to host-imposed stresses that limit its growth and ability to establish an infection. One important immune-regulated host defense mechanism involves competition between host and pathogen for tryptophan (Trp). Although Mtb is a Trp proto...

When the fat is missing: a fat-free spindle cell lipoma in a young woman

Dear Editor, Spindle cell lipoma (SCL) is a benign adipocytic neoplasm first characterized by Enzinger and Harvey, classically arising in the posterior neck, shoulder, and upper back of middle-aged to older men. Histologically, it is defined by a variable admixture of mature adip...

Pediatric Literacy Promotion for Latino Families by Texts and Referrals: A 3-Arm RCT

OBJECTIVE: To test 2 strategies designed to enhance primary care-based literacy promotion (LP): (1) text message reminders (texts), and (2) texts plus referral to community resources. METHODS: We recruited 630 Latino caregiver-infant (aged 6 to 12 months) dyads for an effectivene...

DNA Methylation Biomarkers: From Precancerous Lesions to Adenocarcinoma in the Stomach and Esophagus

Esophageal adenocarcinoma (EAC) and gastric cancer (GC) remain major causes of cancer-related mortality worldwide, largely because of late-stage diagnosis. Barrett’s esophagus (BE) is the established precursor setting for EAC, whereas gastric intestinal metaplasia is an important...

Informing the cultural adaptation of a lung cancer screening shared decision-making and navigation intervention for Hispanic adults: a qualitative study

Abstract Background Lung cancer is the leading cause of cancer-related death among Hispanic men and the second leading cause among Hispanic women in the United States. Despite evidence that lung cancer screening (LCS) reduces lung cancer mortality through early detection, Hispani...

USING GENETICS TO IMPROVE PSYCHIATRIC HEALTH

Overall Abstract The field of psychiatric genetics has experienced drastic advances over the past decade. Despite this progress, comparatively few studies have addressed how we will use these discoveries to improve human health. In this symposium, we bring together leaders from a...

Rosacea in Patients with Skin of Color: Diagnosis and Management

Rosacea is a chronic central face dermatosis caused by a combination of dysregulated innate and adaptive immunity and hyperreactive cutaneous neurovasculature. Although classically associated with lighter skin phototypes, rosacea may affect up to 2–4% of Black, Asian, Pacific Isl...

Quantitative in vivo flux analysis reveals tumor and host lipogenic remodeling in KRAS-driven lung cancer

Upregulation of de novo lipogenesis is a hallmark of aggressive cancers, underscoring its potential as a therapeutic target. However, metabolic studies of lipogenesis during tumorigenesis in vivo remain limited relative to molecular investigations. Here, we quantitatively examine...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Candida Bloodstream Infection in Left Ventricular Assist Device Recipients: Case Series and Review of the Literature

Abstract Candida bloodstream infection (C-BSI) is a rare infection in patients with left ventricular assist devices (LVADs). We aim to describe the characteristics and outcomes of C-BSI. We performed a retrospective search for C-BSI in patients with LVADs at our institution from...

Penetrating dural venous sinus injury: a scoping review of clinical presentation, operative management, and prognosis

Penetrating injury to the dural venous sinuses (DVS) commonly occurs at the superior sagittal sinus (SSS), transverse sinus (TS), and torcular confluence. While rare, DVS penetrating injuries carry high risk of intracranial hemorrhage, air embolism, and venous infarction. The cur...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Large deviations of piecewise-deterministic Markov processes with application to stochastic calcium waves

Abstract We prove a large deviation principle for piecewise deterministic Markov processes (PDMPs). This is an asymptotic estimate for the probability of a trajectory in the large size limit. Explicit Euler–Lagrange equations are determined for computing optimal first-hitting-tim...

Cardiac imaging biomarkers of heart failure in diabetes for phenotyping, risk stratification, and evaluating therapeutic response

Type 2 diabetes mellitus (T2DM) is a well-established risk factor for the development of heart failure (HF), yet HF risk within this population is highly heterogeneous. Appropriate biomarker selection and a limited mechanistic understanding of the phenotypic subtypes of HF in T2D...

Human‐operant evaluation of synthesized alternative reinforcement and resurgence

Basic research suggests that differential reinforcement with synthesized alternative reinforcement (i.e., delivery of two or more qualitatively different reinforcers contingent on a single alternative response) increases resurgence during disruptions to the contingency. We evalua...

Updated Practice Patterns for Adjuvant Treatment of Recurrent Laryngeal Papillomatosis

OBJECTIVES: Adjuvant medical treatments are used to reduce recurrence rates of recurrent respiratory papillomatosis (RRP). Prior consensus statements on initiation of adjuvants may not reflect current practices, particularly given safety data published in the interval. The object...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Postoperative factors associated with hazardous alcohol use after metabolic and bariatric surgery

Abstract Introduction There is an increased risk of hazardous alcohol use following metabolic and bariatric surgery (MBS). Identifying risk factors of hazardous alcohol use, particularly factors that may differentiate risk among those with regular postoperative alcohol consumptio...

Systematic review on the association between brain-related measures and upper limb movement characteristics after stroke

Abstract Background Upper limb (UL) movements are highly diverse, as are movement deficits following stroke. The relationship that stroke pathology has with UL impairments and their recovery has been studied with an increasingly complex array of neuroimaging and neurophysiology t...