Jilin University

Monitoring of Doxorubicin-Mediated Mitochondria–Lysosome Crosstalk by In Situ Raman Spectroscopy: The Molecular Mechanism during Apoptosis and Implications for Cardiotoxicity

Abstract Doxorubicin is among the most commonly used chemotherapeutic agents for a wide range of cancers. Despite its effectiveness, it poses long-term cardiotoxic risks that elevate mortality among cancer patients. In this study, doxorubicin-mediated mitochondria–lysosome crosst...

PPAR-γ participates in macrophage polarization induced by Pentatrichomonas hominis

Pentatrichomonas hominis ( P. hominis ), a protozoan inhabiting the cecum and colon of humans and vertebrates, is associated with diarrhea. The innate immunity plays a crucial role in defending against parasitic infections. Among these, macrophages are involved in immune evasion,...

A Shallow‐Marine Ecosystem Before Initial Tibetan Plateau Uplift

Abstract The uplift of the Tibetan Plateau profoundly influences global atmospheric circulation, sediment transport, and biodiversity, but its pre‐uplift marine paleoenvironment remains poorly understood. Here we report the first discovery of an in situ benthic fossil assemblage...

Construction of Bioinspired, Multifunctional, Durable, and Superhydrophobic Sponges for Oil–Water Separation Based on Recycled Flexible Foam

Abstract Aiming at simultaneously settling the problem of waste resource recycling, oily wastewater pollution/health risk, flammability, and durability of traditional oil–water separation materials, this work developed the superhydrophobic/superoleophilic sponge materials (P/APP@...

Direct ink writing of soft polymer matrices enables on-the-fly shape morphing in soft robots

Soft robots, with their inherent compliance in material and structure, offer new opportunities for adaptable locomotion in unstructured and confined environments. The ability to reconfigure body shape for switching between locomotion modes and gaits is becoming a defining feature...

Environment‐Regulated Crystal‐Structure Reconfiguration of Hybrid Halide Scintillators Enables Tunable STE Emission Toward Intelligent X‐Ray Imaging

ABSTRACT Developing intelligent x‐ray scintillators requires precise regulation of scintillation emission. However, the complex structural factors governing luminescence in organic–inorganic hybrid metal halides (OIMHs, A m BX n ) remain elusive, limiting their rational design. H...

Colloidal Electrolyte Enables Bulk-to-Interface Stabilization for Aqueous Manganese Metal Batteries

Abstract Aqueous Mn metal batteries combine the potential for high safety and energy density, yet are limited by high water activity, sluggish Mn2+ desolvation, and severe interfacial parasitic reactions, which cannot be resolved by isolated strategies. Here we develop an ether-o...

Multiomics analysis reveals putative neural invasion-associated transcriptional signatures of hepatocellular carcinoma

Perineural invasion (PNI) drives tumor progression, local recurrence, and metastasis in pancreatic, prostate, and head/neck cancers. In hepatocellular carcinoma (HCC), the most common primary liver cancer, classical PNI is rarely observed, and the molecular mechanisms governing H...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

BAsyncFed-IDS: A buffered asynchronous federated learning-based intrusion detection system for in-vehicle networks

The Controller Area Network (CAN) is highly susceptible to malicious attacks due to its lack of encryption and authentication mechanisms, leading to the necessity of intrusion detection systems (IDS). However, centralized data processing not only incurs high storage costs and ban...

CuI / CuO Heterointerface Enables Selective Aqueous Electrosynthesis of 2‐Iodoxybenzoic Acid

Comprehensive Summary Aqueous electrosynthesis of hypervalent iodine(V) oxidants provides a sustainable and oxidant‐free alternative to conventional chemical synthesis, but the electrooxidation of 2‐iodobenzoic acid (IBA) to 2‐iodoxybenzoic acid (IBX) is limited by sluggish react...

Reward Shaping based on Trajectory Quality for offline and hybrid reinforcement learning

Current offline reinforcement learning algorithms typically apply equal learning strength to samples of different quality during training, which can limit the effective utilization of high-quality trajectories. To solve this problem, we propose Reward Shaping based on Trajectory...

ACSL4 inhibition alleviates elevated ATRA-driven spermatogenic damage in chronic colitis with gut microbiota dysbiosis

Chronic colitis is a prevalent, manageable yet incurable disorder whose extraintestinal manifestations impair male reproductive health. However, the primary mechanisms underlying these effects, their molecular targets, and effective mitigation strategies remain largely unclear. T...

Catalytic Shunt for Sustainable Photosynthesis of Hydrogen Peroxide from Hypersaline Organic Wastewater

Abstract Photosynthetic hydrogen peroxide (H2O2) production from organic wastewater offers a sustainable alternative to the energy-intensive anthraquinone process, yet it is severely hindered by rapid quenching of reactive precursors by concentrated salts in hypersaline organic w...

The GPCRVP score reliably predicts the impact of GLP1R human variants on receptor function

Abstract Aims/hypothesis The glucagon-like peptide-1 receptor (GLP1R) is a key regulator of glucose homeostasis and body weight, and a major therapeutic target for type 2 diabetes and obesity. Individual disease risk and response to treatments may vary widely depending on the pre...

A consequence-oriented indicator for dominant heat transfer regime identification in HT‑ATES: The Buoyant Flow Heat Transfer Number

Reliable identification of the dominant heat-transfer regime is essential for evaluating the thermal performance of high-temperature aquifer thermal energy storage (HT-ATES). The Rayleigh number ( Ra ) is widely used for this purpose, but it primarily characterizes the tendency o...

Sex-specific proteomic risk scores reveal distinct cardiovascular risk profiles and improve prediction of major adverse cardiovascular events in hypertension

Abstract Background Individuals with hypertension face a substantial residual risk of major adverse cardiovascular events (MACE), yet current clinical risk models often fail to capture the complex pathophysiological heterogeneity and sex differences within this population. This s...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Multi‐omics characterization of flavor profile differences in the Longissimus thoracis between Angus and Hereford cattle

Abstract BACKGROUND Angus and Hereford cattle are premier breeds widely used in genetic improvement and crossbreeding programs to enhance meat quality, yet the flavor differences between them remain poorly understood. RESULTS In this study, we performed an integrated analysis usi...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...