Iran University of Medical Sciences

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

Harnessing nanomedicine for breast cancer therapy through the immunomodulatory activity of BCc1

Although BCc1 represents a novel nanochelating-based nanomedicine, its route- and dose-dependent impacts on mammary oncogenesis, immunoregulation, and non-coding RNA (ncRNA) dynamics remain poorly defined. Here, female BALB/c mice bearing subcutaneous 4T1 mammary carcinomas were...

Low serum levels of C1q/TNF-related protein-14 (CTRP14) in newly diagnosed type 2 diabetes patients

To measure serum C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) levels in newly diagnosed, treatment-naïve men with type 2 diabetes mellitus (T2DM) and healthy controls, and to investigate their associations with metabolic parameters, the presence of T2DM and insulin re...

Contemporary global prevalence and genotype distribution of human papillomavirus among female sex workers, 2015–2025: an updated systematic review and meta-analysis

Abstract Background Female sex workers experience disproportionate exposure to human papillomavirus (HPV), but estimates of HPV prevalence and genotype distribution vary according to geography, specimen type, diagnostic method, and genotype coverage. This updated systematic revie...

Cytoplasmic expression of the SALL4-A isoform is associated with favorable clinicopathological features in prostate carcinoma

Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related mortality among men worldwide. SALL4, a stem cell-associated transcription factor, has been implicated in tumorigenesis across multiple malignancies. However, most transcriptomic studies do not disting...

Treatment failure and associated factors in pediatric Hodgkin lymphoma: a decade of institutional experience from a middle-income country

Despite excellent overall outcomes in pediatric Hodgkin lymphoma (HL), a subset of patients experiences relapse or primary refractory disease, necessitating intensive salvage therapy and exposing them to additional treatment-related toxicity. Data regarding treatment failure and...

Content and features of electronic dental record systems: A study in a developing country

A comprehensive evaluation of the features and content of Electronic Dental Record (EDR) systems is essential for the effective implementation of these systems. The present study aimed to determine the content and features of EDR systems in dental clinics. In this cross-sectional...

From Classroom to Clinic: A Qualitative Study on Newly Graduated Nurses' Transition to Practice.

BACKGROUND: The global nursing shortage and high turnover rates among newly graduated nurses (NGNs) pose significant challenges to their transition into professional roles. Understanding NGNs' experiences is crucial for identifying the factors contributing to turnover and develop...

An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors

Abstract Background Acute heart failure (AHF) is a significant cardiovascular syndrome characterized by either new-onset heart failure (HF) or acutely decompensated heart failure (ADHF), typically presenting with systemic and pulmonary congestion. The European Society of Cardiolo...

Barriers to mental health screening in Iran’s primary healthcare system and its implications for service improvement

Introduction Mental disorders impose an increasing burden on healthcare systems, particularly in low- and middle-income countries (LMICs). Although Iran integrated mental health services into primary healthcare in the 1980s, screening implementation remains challenging. This stud...

Prevalence of vancomycin- and aminoglycoside-resistant pathogenic enterococci in municipal wastewater: A study in northwest Iran

ABSTRACT The extensive use of antimicrobials has contributed to the emergence of multidrug-resistant (MDR) microorganisms in municipal wastewater. The prevalence, resistance patterns, and virulence factors of Enterococcus species were studied in 25 untreated municipal wastewater...

Expression patterns of miR-429/FN1 and miR-592/TOP2A in breast cancer: Clinicopathological correlations and diagnostic value

Breast cancer remains the most common cancer and a leading cause of cancer-related mortality among women worldwide. Identifying reliable biomarkers is essential for improving disease diagnosis and outcomes. This study aimed to evaluate the expression levels of miR-429 and miR-592...

Water and Liquid Soap Cleaning of Removable Orthodontic Appliances: A Triple‑Blind Randomized Crossover Study of Microbial Load Reduction

Background: To evaluate the effectiveness of water and a liquid soap solution compared with 0.2% chlorhexidine (CHX) mouthwash in reducing microbial load and microbial plaque formation on removable orthodontic appliances. Methods: Forty-two patients aged 9 to 16 years who had new...

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Platelet–NK cell interplay in advanced coronary artery disease is associated with pre-exhausted NK cell dysfunction without upregulation of the immune checkpoint receptor NKG2A

Platelet crosstalk with leukocytes plays a key role in the development of atherosclerosis. However, different immune cells are involved in the disease’s pathology, with Tregs showing protective effects against atherosclerosis, whereas NK cells appear to contribute to both atherog...

Effects of grape seed extract on immune-related gene expression, inflammatory biomarkers, disease activity, and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled trial

Abstract Grape seed extract (GSE), a polyphenol-rich nutraceutical with antioxidant and anti-inflammatory properties, has shown promising effects in preclinical colitis models; however, clinical evidence in patients with ulcerative colitis (UC) remains limited. This study provide...

Association between dietary phytochemical index and pancreatic steatosis in patients with common bile duct stones

The dietary phytochemical index (DPI) may protect against pancreatic steatosis (PS), but evidence is limited. This study examined the association between DPI and PS risk. This case-control study included 278 patients with common bile duct stones at Taleghani Hospital, Tehran, bet...

Cross-cultural adaptation and validation of the Persian version of the International Hip Outcome Tool-12 (iHOT-12-Pr) in young to middle-aged active adults with hip disorders

To our knowledge, no validated Persian version of the 12-item International Hip Outcome Tool (iHOT-12) has been published for assessing active adults with hip disorders. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Persian iHOT-...

Design of a prediction system for intravenous immunoglobulin resistance in hospitalized Kawasaki disease patients with artificial intelligence based on machine learning

Machine Learning (ML) algorithms are widely used as a prediction tool in medicine to support clinical decisions. In this study, the machine learning methods are used to investigate IVIG resistance in Kawasaki disease in a referral center of Iran. This is a retrospective cross-sec...

The effect of intravenous remdesivir on endometrial receptivity in female mice

Objective: Pregnant women with coronavirus disease 2019 (COVID-19) are more likely than nonpregnant women to require admission to an intensive care unit, and many may require antiviral therapy. Remdesivir, an antiviral drug used to treat COVID-19, may exert toxic effects on speci...