Institution
Huazhong University of Science and Technology
Recent research
- BiologyOpen access
Despite their favorable biocompatibility profile, the neurotoxic potential of aminated graphene quantum dots (A-GQDs) remains poorly characterized, especially concerning their environmental impact. Utilizing the planarian Dugesia japonica , a freshwater invertebrate model with a...
- Health & MedicineOpen access
Abstract Background Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders which results in accumulation of glycosaminoglycans throughout the body. MPS I is a subtype characterized by mutations in the α-L-iduronidase (IDUA) gene with subsequent multiorga...
- Physics & SpaceOpen access
Fully tunable on-chip meta-generator for multidimensional Poincaré sphere mapping
Abstract The angular momentum of light can be elegantly mapped onto high-order Poincaré spheres, providing a powerful framework for describing structured light beams. Such beams have shown extraordinary potential across diverse applications, including high-capacity optical commun...
- BiologyOpen access
Cancer metabolism is characterized by profound reprogramming, yet the mechanisms enabling rapid and precise adaptation remain incompletely understood. This review establishes post-translational modifications (PTMs) as the central processing unit of oncogenic metabolic reprogrammi...
- Biology
Enzyme Engineering:From Classical Strategies to AI-DrivenBiocatalyst Design
Abstract Nowadays, enzyme engineering has moved from traditional structure-based mutagenesis and directed evolution to data-intensive, AI-assisted design paradigms that involve the rapid discovery and optimization of biocatalysts. Whereas classical approaches relied on rational d...
- Engineering & Technology
Design method for wide-speed-range variable geometry inlet based on one-dimensional model
Abstract The two-dimensional inlet, a critical component of scramjet engines, encounters substantial design challenges, particularly when operating over a wide-speed range. To accelerate the design process, a one-dimensional model-based methodology is proposed, encompassing three...
- Health & MedicineOpen access
PURPOSE: To evaluate stage-dependent performance of same-session [18F]FDG PET/contrast-enhanced CT (PET/ceCT) for initial breast cancer staging and PET/ceCT-detected relapse patterns during follow-up. METHODS: This retrospective single-centre study included a primary staging coho...
- Health & Medicine
Dendritic cell (DC) vaccines offer professional antigen presentation but are often limited by suboptimal trafficking to lymphoid tissues, whereas whole tumor cell vaccines preserve antigenic diversity yet frequently lack coordinated activation cues for efficient T cell priming. H...
- Materials & Energy
ABSTRACT Sustainable electrochemical synthesis aims to produce high‐value chemicals under mild conditions, but its advancement is hindered by electrocatalyst deactivation caused by the strong adsorption of poisoning intermediates. Strategies that mitigate deactivation by weakenin...
- Engineering & TechnologyOpen access
A Certificateless Encryption-Based Authentication Protocol for Low Earth Orbit Satellite Network
In this letter, a novel access and handover authentication scheme is proposed for Low Earth Orbit (LEO) satellite networks, aiming to achieve lightweight computation, privacy preservation, and seamless secure handover for massive sensor users. Different from traditional certifica...
- Health & MedicineOpen access
A 66-year-old male presented with gross hematuria and a left renal mass. 18 F-FDG PET/CT revealed an FDG-avid mass in the mid-pole of the left kidney with renal vein tumor thrombus. The patient was subsequently enrolled in a clinical trial evaluating the carbonic anhydrase IX (CA...
- BiologyOpen access
Glioblastoma (GBM) exhibits profound metabolic reprogramming, among which the balance between unsaturated and saturated fatty acids (UFA/SFA) emerges as a critical determinant of tumor behavior and treatment response. Recent studies have shown that fatty acid metabolic reprogramm...
- Physics & Space
Hybrid Ultrahigh-QualityEtchless Microcavity forApplications with Low-Dimensional Materials
Abstract Two-dimensional (2D) materials possess exceptional optical properties, holding great potential for the development of advanced linear and nonlinear optoelectronic devices. However, their efficient integration into photonic circuits remains challenging due to the trade-of...
- Health & MedicineOpen access
Attitudes to sex education among undergraduates without medical background in China
This study, guided by the Knowledge-Attitude-Practice (KAP) theory, aimed to investigate the knowledge, attitudes, and needs regarding sex education among undergraduates without medical background at Huazhong University of Science and Technology in Wuhan, China. This cross-sectio...
- Engineering & Technology
Network‐Structured All Organic Composite for High‐Temperature Capacitive Energy Storage
ABSTRACT High‐temperature dielectric polymers are promising for advanced power electronics and electrical systems but often suffer from thermally activated charge transport and breakdown under harsh operating conditions. Here, we demonstrate that high‐loading low‐molecular‐weight...
- Health & MedicineOpen access
The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...
- Health & MedicineOpen access
A non-invasive simplified scoring system to predict airway mucus plugs in asthma
Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....
- BiologyOpen access
Cancer drug response and resistance: molecular mechanisms and combating strategies
Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...
- AI & Computing
Understanding and Detecting Android R8 Compiler Bugs
Android apps currently dominate the smartphone app market, and their reliability will significantly affect user experience and even induce security risks. Since Android Gradle Plugin 3.4.0 (April 2019), the R8 compiler serves as the default infrastructure in the Android build pro...
- Health & MedicineOpen access
Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...