Heidelberg University

From Sealed to Anchored: What a Consortium Ledger Adds to HMAC-Sealed IoT Audit Logs in Ambient Assisted Living

A symmetric integrity seal is worth exactly what its key is worth. Any party holding the keyed-hash (HMAC) key of an Internet of Things (IoT) audit trail can forge a record, re-seal a modified one, and leave no cryptographic trace, so an HMAC-sealed log establishes nothing to an...

Preparing for the tiny predators: Community readiness and perceptions of copepod-based dengue control in eastern guatemala

Background Dengue remains a persistent public health challenge in eastern Guatemala, particularly in communities where irregular water supply, domestic water storage, and limited sanitation infrastructure create favorable conditions for Aedes aegypti proliferation. As concerns in...

Sex-specific associations of the plasma-proteome with incident coronary artery disease

AIMS: The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mechanisms are limited. We integrated genomic and proteomic analyses to investigate sex-specific associations of the plasma-proteome with...

Chronic exposure to aflatoxin B1, ochratoxin A, and citrinin in women and children and associated health risk characterization: blood biomonitoring evidence from rural Bangladesh

Abstract Dietary exposure to mycotoxins—including aflatoxins (AFs), ochratoxin A (OTA), and citrinin (CIT)—represents an important health risk, particularly in low-resource settings with widespread food contamination. This study investigates mycotoxin exposure among 712 participa...

Measurement Properties of Delirium Tools in Pediatric Intensive Care: A Systematic Review

CONTEXT: Delirium is common in pediatric intensive care units. Reliable tools are needed, but evidence on measurement properties remains fragmented. OBJECTIVES: To identify pediatric delirium tools and evaluate their measurement properties and certainty of evidence. DATA SOURCES:...

Precise predictions for trilinear Higgs couplings and Higgs pair production in extended scalar sectors with anyH3 and anyHH

Abstract A central objective of future collider experiments is to probe the structure of the Higgs potential, which requires access to trilinear scalar couplings, in particular the self-coupling of the observed Higgs boson. While this coupling is fixed in the Standard Model (SM),...

Integrative Muscle-Adipose Score (IMAS)

OBJECTIVE: To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients. BACKGROUND: Body composition (BC) reflects nutritional status and metabolic reserves and influ...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

Exercise Training in PAH: Methodological Ingenuity Meets Ethical Complexity

Nicola Benjamin, Ekkehard Grünig; Exercise Training in PAH: Methodological Ingenuity Meets Ethical Complexity, Annals of the American Thoracic Society, , a

Clinical outcome after rescue intracranial stenting: a comparison of the ACCLINO flex and the CREDO heal stenting platforms after failed mechanical thrombectomy

Abstract Purpose Mechanical thrombectomy (MT) is the first-line therapy for patients with acute ischemic stroke due to large vessel occlusion; however, despite substantial advances in MT techniques and devices, mechanical recanalization remains unsuccessful in up to 15% of patien...

Identifying optimal dose head CT acquisition techniques through cluster analysis from 904,209 scans

Abstract Objectives To identify clinically established and frequently utilized routine head computed tomography (CT) acquisition techniques in children and adults that achieve lower radiation. Materials and methods The level of the analysis is at the CT scan (series) level. CT ac...

Federated Medical Image Segmentation under Real-World Label Noise: A Benchmark Suite for Noisy Label Learning Method Selection

Abstract While federated learning (FL) enables collaborative medical image segmentation without centralizing sensitive data, real-world deployment is frequently complicated by cross-site label imperfections such as contour disagreement, missing or additional structures, and confu...

A single-amino-acid cleavage controls global mitochondrial complex integrity

Abstract Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins. Defects in this maturation step are implicated in disease, yet the functional impact in humans remains unclear. Here we show that the intermediate cleaving peptidase ICP55...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations

Abstract Auditory Verbal Hallucinations (AVH) are not exclusive to schizophrenia but also occur in other psychiatric disorders, including Borderline Personality Disorder (BPD). While AVH in SZ has been extensively studied, their neurobiological underpinnings in BPD remain poorly...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Abstract Purpose Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (R...

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Abstract ASTRACT Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking....

West Antarctic subglacial geology distinguished by Pb isotopes and Rb–Sr ages in ice-rafted feldspars

Provenance data from sediment delivered to the marine environment by icebergs can trace past ice sheet dynamics and help constrain the ice sheet models used in sea level projections. This approach requires an interpretative framework, but in Antarctica, blanketing ice sheets hind...

The Impact of Mindfulness as a Session‐Introduction on Symptoms and Alliance in Individual Cognitive‐Behavioral Therapy With Children and Adolescents: A Randomized Controlled Trial

ABSTRACT Objectives Mindfulness is increasingly being implemented in child and adolescent therapy. However, little is known about its effectiveness in individual settings within a clinical outpatient context. We investigated the effects of session‐introducing mindfulness interven...