Heidelberg University

Logrolling affects the relative performance of majority and unanimity rule

Abstract We consider a committee facing binary decisions on a number of proposals. If members vote sincerely and payoffs are symmetrically distributed, we show analytically that simple majority rule is the best q-majority rule in an aggregate or expected payoff sense. We argue th...

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Endolysosomal dysfunction is a hallmark of Alzheimer’s disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregatio...

Towards A Universal Analytical Model of Population III Star Formation: A Bridge Between Cosmological Scales and Protostars

Abstract We construct an analytical model of Population III star formation that connects the cosmological radiation background to sub-AU protostellar disk fragmentation, a dynamic range inaccessible to any single simulation. Our approach is based on combining separate models of t...

miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities

Abstract Background T cell-based immunotherapies have improved cancer treatment, however their efficacy is frequently limited by tumor-intrinsic resistance mechanisms and by the immune suppressive tumor microenvironment, counteracting tumor specific immune responses through impai...

OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local mid-size language models

Abstract Oncology notes contain the richest clinical detail, yet they remain largely inaccessible at scale because extracting structured phenotypes requires either substantial language model infrastructure, curated training data, or cloud computing under regulatory constraints. W...

Observation of critical scaling in the Bose gas universality class

Critical exponents characterize the divergent scaling of thermodynamic quantities near phase transitions and allow for the classification of physical systems into universality classes. While quantum gases thermalizing by interparticle interactions fall into the XY model universal...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

Abstract The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders

Abstract Tardive dyskinesia (TD) is a persistent sensorimotor syndrome associated with antipsychotic exposure in schizophrenia spectrum disorders (SSD) and mood disorders (MOD), yet its neurobiological basis remains poorly understood. We investigated whether TD represents a disti...

Radiocarbon in atmospheric CH 4 and CO 2 at Jungfraujoch in 2019–2024: influence of regional nuclear emissions and current global atmospheric 14 CH 4 signal

Abstract. Radiocarbon (14C) is a valuable tracer to determine the relative fossil fractions of emitted carbonaceous greenhouse gases, such as CO2 and CH4. While atmospheric ∆14CO2 measurements have been conducted at multiple sites for several decades, ∆14CH4 measurements remain m...

Effectiveness of an interactive music tablet intervention to reduce procedural anxiety in children: a randomized controlled trial

Abstract Procedural anxiety in children is common and associated with maladaptive behavior, reduced cooperation, and increased perioperative stress. Although music-based interventions show promise, few are designed for routine clinical care. We evaluated an interactive tablet-bas...

DVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in C. elegans

Telomeres are repetitive DNA sequences at the ends of linear chromosomes bound by specialized proteins. In our previous quantitative proteomics screen for telomere-binding proteins of Caenorhabditis elegans , we identified DVE-1, a homolog of mammalian SATB proteins and a transcr...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Harnessing biological variability for mechanistic inference: A stochastic framework applied to neural stem cell dynamics

Inter-individual heterogeneity is often treated as noise, yet its temporal evolution can reveal regulatory mechanisms hidden from mean-field behavior. We present a stochastic framework that exploits variability for mechanistic inference in cell population dynamics. Using adult ne...

The filtration performance of fabrics against particles of viral size: a systematic review

Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data av...

Lessons from the field: usability (engineering) in regulated healthcare

Abstract Regulated healthcare settings continue to face gaps between established HCI methodology, user-centered design principles, and everyday clinical practice. Although standards and regulatory frameworks mandate usability engineering, their integration into regulated clinical...

Fast-Forward: Automatic Assignment and Assessment of Bonded Parameters for the Martini Force Field

Abstract Coarse-grained molecular dynamics simulations of bio- and macromolecular systems offer a method of accessing otherwise unobtainable time and length scales, compared to atomistic simulation techniques. However, a limiting step is often the generation and validation of the...

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

BACKGROUND AND PURPOSE: Myeloid cell leukaemia-1 (MCL-1) is an essential anti-apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL-1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardioto...

The Radical Chemistry of 2,3‐Diguanidinopyridines: Coordination and Visible‐Light Photochemistry

Guanidino-functionalized aromatics (GFAs) comprise an important class of redox-active organic molecules and ligands with a variety of applications. In this work, we report the synthesis and chemistry of novel GFAs with a pyridine core functionalized in 2 and 3 positions with two...