Heidelberg University

Control of organ size by TAS3A

Summary Plant organ size depends on the coordination of cell proliferation and expansion, a process regulated by numerous factors, including transcription factors and small RNAs. However, how different small‐RNA pathways are integrated with growth‐regulating transcriptional netwo...

Durable treatment response to Trastuzumab deruxtecan in two patients with recurrent grade III anaplastic ependymoma

Abstract Background Anaplastic ependymoma is a rare and aggressive central nervous system malignancy for which effective systemic treatment options are limited. Trastuzumab deruxtecan (T-DXd), an antibody–drug conjugate targeting human epidermal growth factor receptor 2 (HER2), h...

Intraluminal thrombus burden is an independent imaging predictor of distal runoff impairment in popliteal artery aneurysms

Background : In popliteal artery aneurysms (PAAs), computed tomography angiography (CTA)-derived intraluminal thrombus burden and distal runoff vessel patency remain insufficiently characterized. We examined this relationship and the added value of thrombus burden assessment in C...

Retinal nerve fibre layer thickness change in the parapapillary region

Purpose To assess radial changes in the retinal nerve fibre layer thickness (RNFLT) in the temporal parapapillary region. Methods Using radial optical coherence tomographic images of the optic nerve head, we measured in a sample of participants of the population-based Beijing Eye...

Visualising Physcomitrium patens protoplasts with full‐rotation soft X‐ray tomography

Abstract Soft X‐ray tomography (SXT) is a label‐free, high‐resolution imaging modality that is optimal for 3D visualisation of whole hydrated cells. Although SXT has been extensively used to study remodelling in more than 130 mammalian cell lines, its application to plants remain...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Dirichlet domains for Anosov subgroups

Abstract We introduce a sufficient condition for a finitely generated subgroup Γ of a semisimple Lie group 𝐺 to admit finite-sided Dirichlet domains for polyhedral Finsler metrics on the symmetric space G / K G/K . The condition always implies the Θ-Anosov condition for some Θ, a...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

MAIA frailty subgroup analysis: long-term follow-up with daratumumab plus lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma

Abstract In MAIA (Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) and overall survival (OS) versus Rd in tran...

Modular Synthesis of γ-Chloro Ketones through Carbochlorination of Alkenes Mediated by Copper(I) Photoredox Catalysis

Abstract γ-Chloro ketones are multifunctional synthons that serve as versatile linchpins for the rapid assembly of molecular complexity. Despite this strategic value, their broader adoption remains conspicuously limited as a consequence of the intrinsic challenges associated with...

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

ABSTRACT Extracellular vesicles (EVs) are mediators of intercellular communication and promising protein‐delivery vehicles, but isolation of sufficiently pure, intact, engineered EVs remains challenging due to abundant cellular and serum‐derived contaminants. Here, structure‐guid...

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

Predicting nonunion – a hybrid machine-learning model combining patient factors and mechanobiological simulation features exceeds clinician accuracy

Aims To compare the accuracy of a mechanobiological simulation against that of clinicians in forecasting long bone nonunions, and to determine whether the simulation’s results can be effectively used as input for a machine-learning algorithm. Methods This was a retrospective diag...

German inpatient penicillin allergy delabeling cost-impact model: code, inputs, and reproducibility package

This package contains the R script, Excel input workbook, supplementary methods, and run instructions for a cost-impact model of inpatient penicillin allergy delabeling in Germany. The script generates results tables and figures for the index episode and ten-year follow-up. The s...

Ethical and design considerations related to automated, confidential HIV testing invitations: insights from senders and recipients of SMS-based HIV testing invitations in Tanzania

Abstract Background Identifying individuals with undiagnosed HIV remains a global challenge. Mobile health (mHealth) approaches that leverage social networks hold potential to increase HIV testing uptake but also raise ethical considerations. Methods We conducted a qualitative st...

The landscape of allele-specific expression in human kidneys

Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome...

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span

Abstract Background Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains...

AI Dermatology's Unfulfilled Promise: Why Early Melanoma Detection Remains Unverified

A growing number of artificial intelligence (AI) systems for melanoma diagnosis now match dermatologist-level performance. Early detection is a driving factor, yet it is rarely validated beyond aggregate diagnostic accuracy. More targeted studies are necessary so these claims bec...

Revisiting the Authoritative/Formal Distinction

Distinguishing between authoritative and formal normativity is a staple component in the metanormative literature. Norms such as morality and prudence count as genuinely or authoritatively normative, while those norms concocted on the spot are only formally normative. In this art...