Hebei Medical University

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Latent Profile Analysis of Childhood Trauma and Loneliness Among Community-Dwelling Older Adults and Their Association with Depressive Symptoms

BACKGROUND: Depression is a leading mental health concern among community dwelling older adults, with childhood trauma and current loneliness identified as critical risk factors. However, existing research has predominantly examined these variables in isolation, obscuring heterog...

Physeal Sparing Posterior Cruciate Ligament Reconstruction in Paediatric Patients With Open Physes Using an Outside‐In Femoral Tunnel and a Low Tibial Tunnel

Abstract In recent years, with increasing participation of adolescents in sports activities, the incidence of posterior cruciate ligament (PCL) injuries in paediatric patients has been increasingly reported. Conventional PCL reconstruction techniques typically require drilling fe...

Hyperopic reserve depletion and myopia burden among primary school students in Xingtai, China, 2 years post-covid-19: a cross-sectional study with refraction validation

Myopia has become a global public health crisis with an annual economic burden of up to $202 billion. Hyperopic reserve (HR) plays a pivotal role in myopia prevention, as excessive near-work in children depletes physiological HR, accelerates emmetropization, and leads to early my...

Molecular and clinical characterization of human adenovirus in hospitalized pediatric respiratory infections: a five-year study

Abstract Background Human adenovirus (HAdV) is a major pathogen of responsible for respiratory tract infections (RTIs) in children in China. This study analyzed clinical data from hospitalized pediatric HAdV infections over a five-year period to characterize the epidemiology, cli...

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

The accumulation of Advanced Glycation End Products (AGEs), resulting from the Maillard Reaction formed via exogenous intake from food and a hyperglycemic internal environment in the body, can cause or exacerbate various complications of Diabetes Mellitus. This article discusses...

Pre-treatment serum bicarbonate predicts survival in patients with locally advanced esophageal squamous cell carcinoma undergoing definitive radiotherapy: a retrospective propensity score matching study

This study aimed to evaluate the prognostic value of pre-treatment serum bicarbonate (HCO 3 − ) for overall survival (OS) and progression-free survival (PFS) in locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients undergoing definitive radiotherapy. Patients wit...

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a novel marker for periodontitis risk

Periodontitis has been linked to dyslipidemia, but the relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and periodontitis remains unclear. This study aimed to investigate their association and develop a risk pr...

Clinical efficacy of unilateral biportal endoscopic spinal decompression for lumbar intraspinal pneumatosis

<title>Abstract</title> Study design: Retrospective observational study. Objective To analyze the short-term clinical efficacy of unilateral biportal endoscopic (UBE) spinal decompression in the treatment of lumbar intraspinal pneumatosis. Background Lumbar intraspinal pneumatosi...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Thrombus molecular markers and thromboelastogram as early predictors of venous thromboembolism after total knee arthroplasty in perioperative elderly patients

Elderly patients undergoing total knee arthroplasty have a higher incidence of venous thromboembolism (VTE) owing to age, surgical trauma, and other factors. Numerous studies have employed the Caprini scale and d -dimer levels to evaluate perioperative coagulation function and pr...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Fibroblast Growth Factor 21 and Its Relationship with Central Precocious Puberty in Girls

Abstract Background Studies have found that obesity and insulin resistance are linked to central precocious puberty (CPP) in girls, while serum fibroblast growth factor 21 (FGF21) levels are associated with obesity and insulin resistance and related to ovarian development, reprod...

Automatic measurement of knee parameters in three-dimensional computed tomography models: a deep learning-based approach

This study evaluates a deep learning algorithm for automated measurement of knee parameters from three-dimensional (3D) computed tomography (CT) reconstructions. We analyzed 323 CT scans from patients with normal knee morphology (mean age 39.10 ± 11.34 years; 200 male), randomly...

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Postoperative pain impairs patients' quality of life. Mechanisms underlying postoperative pain remain incompletely understood. We investigated postoperative pain in a mouse model of skin plus deep tissue incision (INC). We found Cxcl5 was among the top upregulated genes in incisi...

Characteristics of intrauterine microecology and Lactobacillus-associated immune profiles in patients with chronic endometritis

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium implicated in infertility and recurrent implantation failure. Microbial dysbiosis and altered immune responses are increasingly recognized as central features of its pathogenesis. This study aimed...

Expression, association with clinicopathological features and prognostic potential of FOXR2, mTOR, HIF−1α and PKM2 in high−grade serous carcinoma of the ovary

High−grade serous carcinoma (HGSC) of the ovary is the most common and deadly subtype of gynecological malignancy. More and more studies have shown that Forkhead Box R2 (FOXR2) is a carcinogenic driver that can enhance cell growth and tumor formation. However, the role of FOXR2 i...

Association between A Body Shape Index (ABSI) and lung cancer risk among never-smoking women in Northern China: a population-based prospective cohort study

Abdominal obesity, particularly visceral fat accumulation, increases the risk of lung cancer. As a novel anthropometric metric, A Body Shape Index (ABSI) offers improved quantification of abdominal obesity. This study aimed to investigate the association between ABSI and lung can...

Prognostic value of the inflammatory prognostic index for postoperative recurrence in non-muscle-invasive bladder cancer

Abstract Background To evaluate the prognostic value of the inflammatory prognostic index (IPI) for recurrence after transurethral resection of bladder tumour (TURBT) in non-muscle-invasive bladder cancer (NMIBC), and to compare its discriminatory performance with that of the neu...