Hebei Medical University

The Role of Eccentric Contraction Training in the Postoperative Rehabilitation of Patients With Total Knee Arthroplasty

ABSTRACT Background Eccentric contraction training may be associated with improved functional recovery after total knee arthroplasty (TKA), but its effects on pain, range of motion, and patient‐reported outcomes during the early postoperative period remain unclear. This randomize...

Diagnostic performance of combined ultrasound parameters, B-hCG, and estradiol in early caesarean scar pregnancy and their association with intraoperative bleeding during curettage

Cesarean scar pregnancy (CSP), a serious complication following cesarean section, may increase the risk of massive intraoperative bleeding and hysterectomy due to the implantation of the gestational sac at the uterine scar site. This study employed a prospective cohort analysis t...

MiR-107 serves as a clinical biomarker for acute pancreatitis and promotes inflammation and fibrosis

Abstract Background Acute pancreatitis (AP) has a high risk of poor prognosis, yet effective biomarkers for diagnosis and prognosis remain limited. Pancreatic stellate cells (PSCs) play a central role in pancreatic inflammation and fibrosis. Purpose To investigate the diagnostic...

Exploring Priority Intrapartum Services Associated with Childbirth Experience During Vaginal Birth: A Multicenter Cross-Sectional Study

Background: A woman’s childbirth experience is important to her health and family well-being. Evidence-based intrapartum care may support a positive experience. When resources are constrained, identifying services that are most strongly associated with childbirth experience may h...

Diagnostic accuracy and prognostic value of lncRNA H19 in gastric cancer: a systematic review and meta-analysis

Abstract Background LncRNA H19 is upregulated considerably in gastric cancer and participates in its apoptosis, proliferation, migration, invasion, and metastasis. The objective of this meta-analysis is to demonstrate its diagnostic and prognostic values for gastric cancer. Metho...

Clinical efficacy of proximal femoral nail antirotation (PFNA) combined with denosumab in the treatment of osteoporotic intertrochanteric fractures

To investigate the clinical impact of PFNA internal fixation combined with denosumab on fracture healing, bone mineral density (BMD), hip joint functional recovery, and refracture incidence in patients with osteoporotic intertrochanteric fractures. A total of 99 elderly patients...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

Exosomes From Cancer‐Associated Fibroblasts Suppress Ferroptosis and CD8 + T Cell Effector Function in Gastric Cancer via miR ‐4435/ NDUFA10 Axis

ABSTRACT Cancer‐associated fibroblasts (CAFs) are pivotal stromal component in tumor microenvironment (TME) and participate in regulating tumor development and progression via exosomes (exos) mediated intercommunication. However, the intricate mechanism underlying the exosomal mi...

Prenatal management and outcomes in mirror syndrome: report of two cases

Mirror syndrome (MS) is a rare obstetric complication characterized by fetal hydrops, placental edema, and maternal edema accompanied by the triad of hemodilution. MS is often misdiagnosed as preeclampsia, and its management must target the underlying fetal etiology. Currently, t...

A Novel Suture-Based Otoplasty Technique Combining Figure-of-Eight and Mattress Sutures for Prominent Ear Correction: A Retrospective Study of 89 Patients

BACKGROUND: Prominent ear is a common congenital deformity that can cause significant aesthetic and psychosocial concerns. This study introduces a novel suture-based otoplasty technique that combines figure-of-eight and mattress sutures to achieve natural-appearance aesthetic out...

The membrane skeleton density of red blood cells in MYH9 -related disease patients is decreased

MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased pl...

Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection

Given the aging population, we aimed to evaluate the long-term outcomes and prognostic factors of overall survival (OS) in elderly patients who underwent endoscopic submucosal dissection (ESD) for early esophageal squamous cell carcinoma (ESCC). Between January 2000 and June 2022...

Biomechanical advantages of the proximal femoral bionic nail with triangular support structure in the treatment of intertrochanteric fractures: a coronal fracture heatmap modeling and finite element comparison of three implant designs

Coronal fracture fragments (CFs) are highly prevalent in intertrochanteric fractures and represent a significant risk factor for internal fixation failure. This study combined anatomical and engineering approaches to construct the first coronal fracture heatmap model and evaluate...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

Surface-Engineered Phytochemical Nanomedicines for Postmenopausal Osteoporosis: Skeletal Targeting, Imaging-Supported Evaluation, and Therapeutic Performance

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency and a major contributor to fragility fractures, yet long-term use of current antiresorptive and anabolic agents remains constrained by tolerability and adherence. Plant-derived bioactive...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

Effectiveness and clinical characteristics of biologic switching in severe asthma patients with inadequate response to initial biologic therapy: a systematic review

Bronchial asthma (hereafter referred to as asthma) is a common chronic inflammatory airway disease affecting more than 300 million people worldwide. Although most patients achieve control with conventional or biologic therapies, a subset of patients with severe asthma has an inad...

Integration of transcriptome and metabolome analyses reveals the mechanism of high-quality formation in Salvia miltiorrhiza

Salvia miltiorrhiza is an important medicinal plant, and its medicinal value is largely associated with specialized metabolites such as tanshinones and salvianolic acids. However, systematic evaluation of high-performing candidate germplasms and the molecular features associated...

MiR-323b-5p regulates the development of childhood asthma by targeting the RNF24 gene

Childhood asthma is a chronic respiratory disease characterized by airway hyperresponsiveness and chronic inflammation, which involves immune dysregulation and may be associated with microRNA (miRNA) dysregulation. Exploring the clinical significance of miR-323b-5p in childhood a...

The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics

Polystyrene microplastics (PS-MPs) are environmental pollutants linked to cardiovascular diseases. This study investigated PS-MP-induced vascular toxicity mechanisms in mice. Mice were divided into saline control, low/medium/high PS-MP exposure (0.1, 1, and 10 mg/kg/d), and PS-MP...