Hebei Medical University

ZAR1/ZAR2-mediated maternal mRNA fate control in oocyte maturation and early embryonic development

Abstract Oocyte maturation and early embryonic development following fertilization occur during a phase of restricted transcriptional activity and are highly dependent on the storage, translational activation, and timed clearance of maternal mRNAs. In recent years, zygote arrest...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Preparation and in vitro characterization of luteolin-loaded liposome/GelMA composite microspheres and associated macrophage and osteogenic responses

Abstract Background The chronic inflammatory microenvironment of periodontitis impairs periodontal tissue repair. Biomaterials that combine local delivery with immunomodulatory and osteogenic functions may support periodontal regeneration. This in vitro study developed a luteolin...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Self-Referenced SERS Nanoprobe for Accurate and Real-Time Monitoring of Nitroreductase Activity in Hepatic Ischemia

Abstract Hepatic ischemia-reperfusion injury (HIRI) represents a severe complication in liver surgery and transplantation, thus early identification of ischemic damage, specifically the hallmark hypoxia, is pivotal for prognosis. However, the specific tools for detecting ischemic...

Arthroscopic Fixation of Posterior Cruciate Ligament Tibial Avulsion Fractures With Single‐Suture and Dual EndoButtons via the Lateral Aspect of the Anterior Cruciate Ligament

Abstract Arthroscopic techniques have gradually replaced open surgery as a routine method for treating posterior cruciate ligament tibial avulsion fractures. However, traditional arthroscopic surgery is associated with problems such as limited visualization, unstable fixation, an...

Global, regional, and national burden of low-back pain attributable to smoking from 1990 to 2021: An age-periodcohort and joinpoint analysis of the Global Burden of Disease Study 2021

INTRODUCTION: Low-back pain (LBP) is the leading cause of disability worldwide. Although smoking is a well-established, modifiable risk factor that accelerates intervertebral disc degeneration, comprehensive spatiotemporal analyses of its attributable burden remain scarce. This s...

Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns

Abstract Evidence on associations between green space, air pollution mixture, and heterogeneous biological aging patterns remains limited. We investigated the opposing effects of green space and air pollution mixture on biological aging patterns using an accelerated longitudinal...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Association between the preoperative geriatric nutritional risk index and loss of walking independence 180 days after hip fracture surgery: A retrospective cohort study

Abstract Background Malnutrition may impair recovery after hip fracture, but the association between preoperative geriatric nutritional risk index (GNRI) and postoperative walking outcomes remains unclear. We examined the association between GNRI and loss of walking independence...

Radiographic outcomes of CT-based robotic-assisted versus manual direct anterior total hip arthroplasty with an acetabular-only registration workflow: a retrospective cohort study

Limited exposure through the direct anterior approach may restrict robotic registration to the acetabulum. We compared postoperative radiographic outcomes of CT-based robotic-assisted DAA THA performed with an acetabular-only bony registration workflow with manual DAA THA. This r...

Correlation Between CT Manifestations and Treatment Strategy in Nasal Bone Fractures

Objective: To determine the association between detailed CT manifestations of nasal bone fracture and treatment strategy, emphasizing whether CT-derived structural severity can stratify conservative treatment, closed reduction, and open reduction/septorhinoplasty. Methods: This r...

New findings of swept-source optical coherence tomography angiography in Sturge–Weber syndrome with circumscribed choroidal hemangioma: a case report

Abstract Background Circumscribed choroidal hemangioma is not associated with systemic diseases,while it can also occasionally occur in Sturge-Weber syndrome patients. Swept-source optical coherence tomography angiography (SS-OCTA) offers a non-invasive imaging modality for diagn...

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges. This study aimed to iden...

Association between the number of missing/replaced teeth and Chronic Kidney Disease (CKD): cross-sectional analysis of NHANES data

This study aimed to investigate the association between the number of missing/replaced teeth and chronic kidney disease (CKD), and whether there is a dose-response relationship with markers of renal function. Utilizing data from the National Health and Nutrition Examination Surve...

Nocardia gipuzkoensis: clinical characterization, identification, and antimicrobial susceptibility

Nocardia gipuzkoensis was first described as a novel species in 2020. To date, infections caused by N. gipuzkoensis have rarely been reported. The prevalence of N. gipuzkoensis may be severely underestimated because N. gipuzkoensis was misidentified as Nocardia abscessus with 16...

Prognostic value of CD8+ TILs and MMR status and their correlation with clinical outcomes in rectal cancer

Abstract Objective To explore the relationship between CD8 + tumor-infiltrating lymphocytes (TILs) in rectal cancer, mismatch repair (MMR) status, and patient prognosis. Methods A total of 414 paraffin-embedded tissue samples from patients with pathologically confirmed stage Ⅰ–Ⅲ...

Association between disease awareness and prognosis in patients with glioblastoma

This study aimed to evaluate whether disease awareness among Chinese patients with glioblastoma was associated with prognosis. This single-center, retrospective cohort study included consecutive patients diagnosed with glioblastoma between February 2009 and August 2020. Disease a...

Left bundle branch area pacing in atrial fibrotic cardiomyopathy manifesting as atrial standstill: two case reports and mechanistic insights

Atrial standstill (AS) is a rare arrhythmogenic disorder characterized by the complete absence of atrial electrical and mechanical activity, most commonly resulting from atrial fibrotic cardiomyopathy (AFC). Optimal management remains challenging, particularly when selecting an a...